This work was supported by National Natural Science Foundation of China (grant no. 81702884), Natural Science Foundation of Shandong Province (grant nos. ZR2022MH272 and ZR2023QH115), Medicine and Health Science and Technology Foundation of Shandong Province (grant no. 202111000399 and 202202080721), Traditional Chinese Medicine Science and Technology Foundation of Shandong Province (grant no. M-2022122). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.