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The causal relationships between mitochondria and six types of cancer: a Mendelian randomization study

Mitochondria play a multifaceted role in tumorigenesis, influencing energy metabolism, redox balance, and apoptosis. Howev...

Bmc Cancer

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Gadoxetic acid-enhanced MRI for identifying cholangiocyte phenotype hepatocellular carcinoma by interpretable machine learning: individual application of SHAP

Cholangiocyte phenotype hepatocellular carcinoma (HCC) is highly invasive. This study aims to develop and validate an opti...

Bmc Cancer

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HbA1c levels and breast cancer prognosis in women without diabetes

Diabetes is associated with impaired breast cancer prognosis; however, the effectiveness of glycosylated hemoglobin (HbA1c...

Bmc Cancer

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Autologous stem cell transplantation for adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission. A study by the Acute Leukemia Working Party of the EBMT

The role of autologous hematopoietic stem cell transplantation (AHSCT) in adults with Philadelphia chromosome-negative acu...

Bmc Cancer

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Comparing the biopsy strategies of prostate cancer: a systematic review and network meta-analysis

The introduction of three kinds of magnetic resonance imaging-guided prostate biopsies (MRI-PB) has changed the paradigm r...

Bmc Cancer

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Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinsons Disease Psychosis

Background Cognitive deficits and reduced dopamine transporter (DAT) binding ratio have been reported in Parkinson’s disea...

Evidence-based Mental Health

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Co-prescription of metformin and antipsychotics in severe mental illness: a UK primary care cohort study

Background Metformin is a pharmacological candidate to mitigate second-generation antipsychotic (SGA)-induced weight gain ...

Evidence-based Mental Health

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Measuring social environment factors of inpatients and outpatients with depression in Germany: a cross-sectional study

Background Social environment characteristics, including social relationships and cultural milieus, may influence the occu...

Evidence-based Mental Health

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Climate change worry and the association with future depression and anxiety: cross-national analysis of 11 European countries

Background Climate change affects people’s mental health directly and indirectly. Climate anxiety, characterised by persis...

Evidence-based Mental Health

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Single-session intervention with and without video support to prevent the worsening of emotional distress among healthcare workers during the SARS-CoV-2 pandemic: a randomised clinical trial

Background The SARS-CoV-2 pandemic was a major stressful event that significantly affected healthcare providers.Objective ...

Evidence-based Mental Health

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Predicting the incidence of depression in adolescence using a sociodemographic risk score: prospective follow-up of the IDEA-RiSCo study

Background Adolescence constitutes a critical window for preventing depression, but efforts have mostly targeted single ri...

Evidence-based Mental Health

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Risk of hospitalisation for first-onset psychosis or mania within a year of ADHD medication initiation in adults with ADHD

Background The prevalence of attention-deficit hyperactivity disorder (ADHD) drug treatment for youth and adults has been ...

Evidence-based Mental Health

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Methodological quality in randomised clinical trials of mental health apps: systematic review and longitudinal analysis

Question This study investigated the methodological rigour of randomised controlled trials (RCTs) of mental health apps fo...

Evidence-based Mental Health

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Psychotherapies for adults with complex presentations of PTSD: a clinical guideline and five systematic reviews with meta-analyses

Objective To develop a clinician-guided, research-based guideline for adult outpatient psychotherapy for complex presentat...

Evidence-based Mental Health

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Leveraging artificial intelligence in the prediction, diagnosis and treatment of depression and anxiety among perinatal women in low- and middle-income countries: a systematic review

Aim The adoption of artificial intelligence (AI) tools is gaining traction in maternal mental health (MMH) research. Despi...

Evidence-based Mental Health

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Access to treatment protocols and manuals for evidence-based psychological interventions for severe mental disorders: a survey of randomised trials included in network meta-analyses

Background Evidence-based psychological interventions for mental disorders are described in treatment protocols and manual...

Evidence-based Mental Health

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Increased prevalence of urticarial diseases and antihistamine/corticosteroid consumption in patients with attention-deficit/hyperactivity disorder

Objectives This nationwide cohort study investigated the association between attention-deficit/hyperactivity disorder (ADH...

Evidence-based Mental Health

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"I am not a priority": ethnic minority experiences of navigating mental health support and the need for culturally sensitive services during and beyond the pandemic

Background Existing health inequalities and the lack of timely and appropriate support have long been a reality for many e...

Evidence-based Mental Health

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Impact of the COVID-19 pandemic on antidepressant prescribing with a focus on people with learning disability and autism: an interrupted time series analysis in England using OpenSAFELY-TPP

Background COVID-19 restrictions led to increased reports of depressive symptoms in the general population and impacted he...

Evidence-based Mental Health

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Editorial: Tumour Virus Research on Virus Host Interactions and Cell Transformation