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Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice
Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice
Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities on ...
The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
Numerous cardioprotective interventions have been reported to reduce myocardial infarct size (IS) in pre-clinical studies....
Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis
Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis
Nuclear factor of activated T cells 5 (NFAT5) is an osmosensitive transcription factor that is well-studied in renal but r...
Macrophages enhance sodium channel expression in cardiomyocytes
Macrophages enhance sodium channel expression in cardiomyocytes
Cardiac macrophages facilitate electrical conduction through the atrioventricular-node (AV) in mice. A possible role for c...
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study
Ventricular fibrillation (VF)-induced cardiac arrest frequently complicates ST-segment elevation myocardial infarction (ST...
Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells
Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells
The heterogeneity of endothelial cells (ECs) across human tissues remains incompletely inventoried. We constructe...
Investigating the cause of cardiovascular dysfunction in chronic kidney disease: capillary rarefaction and inflammation may contribute to detrimental cardiovascular outcomes
Investigating the cause of cardiovascular dysfunction in chronic kidney disease: capillary rarefaction and inflammation may contribute to detrimental cardiovascular outcomes
Myocardial ischemia–reperfusion (IR) injury is a major cause of morbidity and mortality in patients with chronic kid...
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Despite recent progress, ischemic heart disease poses a persistent global challenge, driving significant morbidity and mor...
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolis...
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium (Ca2+) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitocho...
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Understanding the mechanisms underlying vascular regeneration in the heart is crucial for developing novel therapeutic str...
Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies
Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies
CD40L–CD40–TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary...
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Placental growth factor (PlGF)-2 induces angio- and arteriogenesis in rodents but its therapeutic potential in a clinicall...
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
Hyperglycaemia is common during acute coronary syndromes (ACS) irrespective of diabetic status and portends excess infarct...
Cardioprotection in cardiovascular surgery
Cardioprotection in cardiovascular surgery
Since the invention of cardiopulmonary bypass, cardioprotective strategies have been investigated to mitigate ischemic inj...
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is inv...
Proprioceptors of the human pericardium
Proprioceptors of the human pericardium
In the human organism, all functions are regulated and, therefore, require a feedback mechanism. This control involves a p...
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor (β3AR) agonists have been shown to protect against ischemia–reperfusion injury (IRI...
Cardioprotection strategies for anthracycline cardiotoxicity
Cardioprotection strategies for anthracycline cardiotoxicity
Thanks to the fantastic progress in cancer therapy options, there is a growing population of cancer survivors. This succes...
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction
Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved ejection fraction (HFpEF). Exp...
Cardiac wasting in patients with cancer
Cardiac wasting in patients with cancer
Patients with cancer face a significant risk of cardiovascular death, regardless of time since cancer diagnosis. Elderly p...
Role of CD4+ T-cells for regulating splenic myelopoiesis and monocyte differentiation after experimental myocardial infarction
Role of CD4+ T-cells for regulating splenic myelopoiesis and monocyte differentiation after experimental myocardial infarction
Myocardial infarction (MI) induces the generation of proinflammatory Ly6Chigh monocytes in the spleen and the recruitment ...
Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification
Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification
Statins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting cholesterol synthesis. These ...
Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise improves cardiac function and metabolism. Although long-term exercise leads to circulating and micro-environmenta...
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Hypertrophic cardiomyopathy (HCM) constitutes the most common genetic cardiac disorder. However, current pharmacotherapeut...
The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity
The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity
Cardiovascular disease is the main factor contributing to the global burden of diseases, and the cardiotoxicity caused by ...
Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre−ER(T)/fl mice by altering the coenzyme Q pool
Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre−ER(T)/fl mice by altering the coenzyme Q pool
Succinate accumulates during myocardial ischemia and is rapidly oxidized during reperfusion, leading to reactive oxygen sp...
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
The right ventricle (RV) differs developmentally, anatomically and functionally from the left ventricle (LV). Therefore, c...
Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic kidney disease-induced myocardial remodeling
Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic kidney disease-induced myocardial remodeling
Chronic kidney disease (CKD) adversely affects the heart. The underlying mechanism and the interplay between the kidney an...
Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities
Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities
Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine t...
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