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Peripheral blood miRNAs are associated with airflow below threshold in children with asthma
Peripheral blood miRNAs are associated with airflow below threshold in children with asthma
MicroRNAs (miRNAs) are crucial post-transcriptional regulators involved in inflammatory diseases, such as asthma. Poor lun...
Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia
Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacolog...
Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children
Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children
Air pollution is associated with poor asthma outcomes in children. However, most studies focus on ambient or indoor monito...
Differences between women and men in prolonged weaning
Differences between women and men in prolonged weaning
In recent years, the importance of sex as a factor influencing medical care has received increasing attention in the field...
Tezepelumab for severe asthma: elevating current practice to recognize epithelial driven profiles
Tezepelumab for severe asthma: elevating current practice to recognize epithelial driven profiles
An increasing amount of evidence supports the relevance of epithelium across the wide spectrum of asthma pathobiology. On ...
Exploring the diagnostic and immune infiltration roles of disulfidptosis related genes in pulmonary hypertension
Exploring the diagnostic and immune infiltration roles of disulfidptosis related genes in pulmonary hypertension
Pulmonary hypertension (PH) is marked by elevated pulmonary artery pressures due to various causes, impacting right heart ...
Transmission electron microscopy of transbronchial lung cryobiopsy samples in a cohort of fibrotic interstitial lung disease patients – feasibility and implications of endothelial alterations
Transmission electron microscopy of transbronchial lung cryobiopsy samples in a cohort of fibrotic interstitial lung disease patients – feasibility and implications of endothelial alterations
We evaluated the utility of transmission electron microscopy (TEM) in transbronchial lung cryobiopsy (TBLC) samples from 1...
Treatment patterns and patient journey in progressive pulmonary fibrosis: a cross-sectional survey
Treatment patterns and patient journey in progressive pulmonary fibrosis: a cross-sectional survey
For patients with interstitial lung diseases (ILDs) presenting with a progressive pulmonary fibrosis (PPF) phenotype, curr...
Dynamics of pulmonary mucosal cytotoxic CD8 T-cells in people living with HIV under suppressive antiretroviral therapy
Dynamics of pulmonary mucosal cytotoxic CD8 T-cells in people living with HIV under suppressive antiretroviral therapy
Despite the success of antiretroviral therapy (ART), people living with HIV (PLWH) suffer from a high burden of pulmonary ...
Clinical, radiological and histopathological features of patients with familial pulmonary fibrosis
Clinical, radiological and histopathological features of patients with familial pulmonary fibrosis
In familial pulmonary fibrosis (FPF) at least two biological relatives are affected. Patients with FPF have diverse clinic...
IPF-related new macrophage subpopulations and diagnostic biomarker identification - combine machine learning with single-cell analysis
IPF-related new macrophage subpopulations and diagnostic biomarker identification - combine machine learning with single-cell analysis
Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown etiology that lacks a specific treatment. In IPF, macr...
Outcomes of different pulmonary rehabilitation protocols in patients under mechanical ventilation with difficult weaning: a retrospective cohort study
Outcomes of different pulmonary rehabilitation protocols in patients under mechanical ventilation with difficult weaning: a retrospective cohort study
The endeavor of liberating patients from ventilator dependence within respiratory care centers (RCCs) poses considerable c...
Trigonelline hydrochloride attenuates silica-induced pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation
Trigonelline hydrochloride attenuates silica-induced pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation
Silicosis represents a paramount occupational health hazard globally, with its incidence, morbidity, and mortality on an u...
Airway disease decreases the therapeutic potential of epithelial stem cells
Airway disease decreases the therapeutic potential of epithelial stem cells
Tissue-engineered tracheal grafts (TETG) can be recellularized by the host or pre-seeded with host-derived cells. However,...
Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review
Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review
Venovenous extracorporeal membrane oxygenation (VV ECMO) has been widely used for severe acute respiratory distress syndro...
Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)
Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) is a common condition associated with critically ill patients, characterized by...
Microbes little helpers and suppliers for therapeutic asthma approaches
Microbes little helpers and suppliers for therapeutic asthma approaches
Bronchial asthma is a prevalent and increasingly chronic inflammatory lung disease affecting over 300 million people globa...
Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases
Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases
Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem i...
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in develop...
Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation
Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation
Acute exacerbation of interstitial lung disease (AE-ILD) significantly impacts prognosis, leading to high mortality rates....
Characterization and inhibition of inflammasome responses in severe and non-severe asthma
Characterization and inhibition of inflammasome responses in severe and non-severe asthma
Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whethe...
Ambient atmospheric PM worsens mouse lung injury induced by influenza A virus through lysosomal dysfunction
Ambient atmospheric PM worsens mouse lung injury induced by influenza A virus through lysosomal dysfunction
Particulate matter (PM) air pollution poses a significant risk to respiratory health and is especially linked with various...
PTK2-associated gene signature could predict the prognosis of IPF
PTK2-associated gene signature could predict the prognosis of IPF
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clini...
Lower myostatin and higher MUC1 levels are associated with better response to mepolizumab and omalizumab in asthma: a protein–protein interaction analyses
Lower myostatin and higher MUC1 levels are associated with better response to mepolizumab and omalizumab in asthma: a protein–protein interaction analyses
Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biol...
Prediction of the number of asthma patients using environmental factors based on deep learning algorithms
Prediction of the number of asthma patients using environmental factors based on deep learning algorithms
Air pollution, weather, pollen, and influenza are typical aggravating factors for asthma. Previous studies have identified...
CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD
CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD
It is now understood that ferroptosis plays a significant role in the progression of chronic obstructive pulmonary disease...
In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis
In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis
IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to respiratory failure. The remod...
METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway
METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway
The accumulation of myofibroblasts is the key pathological feature of pulmonary fibrosis (PF). Aberrant differentiation of...
Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening
Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening
Parametric response mapping (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires bo...
Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands
Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands
People living with chronic obstructive pulmonary disease (COPD) have an increased risk of experiencing cardiovascular (CV)...
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