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Corrigendum to STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice
Published in Volume 135, Issue 14 on July 15, 2025 J Clin Invest. 2025;135(14):e195974. https://doi.org/10.1172/JCI195...
Chemokine gradients spare graft endothelium from CD8+ T cell–mediated injury during allograft rejection
Trafficking signals — specifically, a chemokine gradient within the tissue epithelial compartment — could be responsible ...
HIF-1 promotes murine breast cancer brain metastasis by increasing production of integrin β3–containing extracellular vesicles
Identification of HIF target genes in brain-metastatic BC cells by RNA-Seq and ChIP-Seq. MDA-MB-231-BrM2 (hereafter desig...
FGFR3-induced Y158 PARP1 phosphorylation promotes PARP inhibitor resistance via BRG1/MRE11-mediated DNA repair in breast cancer models
Research ArticleOncology Open Access | 10.1172/JCI173757 Mei-Kuang Chen,1,2 Hirohito Yama...
Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment
Research ArticleCell biology Open Access | 10.1172/JCI189048 Zixi Wang,1 Lei Li,1 Qi ...
Aldehyde metabolism governs resilience of mucociliary clearance to air pollution exposure
Sex as a biological variable. Our study examined both male and female mice, with similar findings observed in both sexes....
Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis–induced cytokine transcriptional responses
Research ArticleGeneticsInfectious disease Open Access | 10.1172/JCI179822 Joshua J. Ivie,1 ...
Evolving concepts in adjuvant/neoadjuvant therapy for resectable pancreas cancer
Given the high rate of distant relapse after surgical resection of PDAC, systemic therapy is essential for curative treat...
The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology
Cells need a constant supply of purine nucleotides (PNs), as PNs play a crucial role in cell signaling, energy transport,...
The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity
Research ArticleGeneticsOncology Open Access | 10.1172/JCI190443 Maud Maillard,1 Rina Nis...
Disruption of the KLHL37–N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models
Research ArticleOncology Open Access | 10.1172/JCI176655 Senfeng Xiang,1,2 Pengfei Chen,1...
Metastatic heterogeneity in pancreatic cancer: mechanisms and opportunities for targeted intervention
To colonize distant organs, tumor cells must extravasate from the vasculature, a process often facilitated by the mechani...
Sending science down yonder
Icahn School of Medicine at Mount Sinai, New York, New York, USA. Find articles by Bright, A. in: P...
School-based health centers and inspiring the next generation of biomedical leaders
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Find articles by Cai, C. in: ...
An approach to targeting Nav1.7 for pain sensations
Alternative approaches, such as targeting intrinsic modulators of Nav1.7 currents in nociceptive neurons, have recently b...
Are you listening?
Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA. Find articles by Pinski, ...
Biomedical education in the era of large language models: a paradigm shift
Department of Otorhinolaryngology–Head & Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains ...
Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques
To test the hypothesis that host age at the time of infection is critical to the course of SIV disease, the pace of host ...
Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models
Research ArticleNeurosciencePublic Health Open Access | 10.1172/JCI183749 Aditya K. Singh,1 ...
Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis
Research ArticleEndocrinologyMetabolism Open Access | 10.1172/JCI179845 Xin Li,1 Jingxin ...
Aldehyde Dehydrogenase 2 rs671 Polymorphism is Associated with Susceptibility of Coronary Atherosclerosis in Patients with Hypertension
Aldehyde Dehydrogenase 2 rs671 Polymorphism is Associated with Susceptibility of Coronary Atherosclerosis in Patients with Hypertension
Assessing relationship between ALDH2 rs671 polymorphism, serum lipids, peripheral inflammation indices, systemic immune in...
Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study
Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study
The aim of this study was to assess the relationships of serum irisin with the severity and prognosis of COVID-19.
Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis
Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis
Exploring relationship between blood lipid level and disease activity, and evaluating early predictive value of blood lipi...
The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling
The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling
This study selected serum samples from normal pregnant women and patients with RA of different statuses and outcomes for P...
The Association Between Mitral Regurgitation and Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Large Sample Cohort Study
The Association Between Mitral Regurgitation and Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Large Sample Cohort Study
Elucidating the connection between MR and long-term clinical outcomes following AMI treated with PCI.
Establishment and Clinical Application of Rh Blood Group Bank in the East China Region
Establishment and Clinical Application of Rh Blood Group Bank in the East China Region
Investigating the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific ...
Trends and Dynamics of Respiratory Viruses in Hospitalized Children of Fuzhou: Insights Into the Impact of COVID-19 Pandemic Control Measures
Trends and Dynamics of Respiratory Viruses in Hospitalized Children of Fuzhou: Insights Into the Impact of COVID-19 Pandemic Control Measures
Changes in the weather can affect how common these viruses are, showing we need to keep watching and take special actions,...
Correlation of Serum Homocysteine Levels With Various Types of Coronary Syndromes (CS) and In-Hospital Mortality – A Multicenter Study
Correlation of Serum Homocysteine Levels With Various Types of Coronary Syndromes (CS) and In-Hospital Mortality – A Multicenter Study
Evaluating the correlation between serum homocysteine levels and various types of coronary syndrome (CS), as well as in-ho...
Prognostic Significance of Serum NLRP3 in Spontaneous Intracerebral Hemorrhage
Prognostic Significance of Serum NLRP3 in Spontaneous Intracerebral Hemorrhage
To determine its ability to predict early neurological deterioration (END) and 3-month neurological outcome after intracer...
Routine Blood Tests as Predictive Tools for Differentiating Follicular Thyroid Carcinoma From Follicular Adenoma
Routine Blood Tests as Predictive Tools for Differentiating Follicular Thyroid Carcinoma From Follicular Adenoma
Developing a predictive scoring system based on routine blood biomarkers to distinguish between FTC and FA, facilitating e...
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