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Weight loss with real-world doravirine use in the OPERA cohort: a US-based cohort study

Weight gain has been associated with the use of antiretrovirals in people with HIV, especially with integrase inhibitors o...

Aids Research And Therapy

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Adverse childhood experiences and disengagement from HIV care: a case-cohort study in Tanzania

Adverse childhood experiences (ACEs) can have lasting, detrimental effects throughout the lifespan and may influence engag...

Aids Research And Therapy

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Risk of uveitis in patients with human immunodeficiency virus: a cohort study through TriNetX database

This multi-institutional, retrospective cohort study using TriNetX database aims to explore the relationship between HIV i...

Aids Research And Therapy

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Cost-Effectiveness Analysis of Expanding Influenza Vaccination to Adults Aged 50 and Over in France

Influenza in France causes, on average, more than 1 million primary care consultations, 20,000 hospitalizations, and 9000 ...

Infectious Diseases And Therapy

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Deep Learning for the Early Diagnosis of Candidemia

Candidemia carries a heavy burden in terms of mortality, especially when presenting as septic shock, and its early diagnos...

Infectious Diseases And Therapy

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Gender Differences in Antibiotic Prescriptions and Healthcare Visits Among Caregivers Accompanying Children with Respiratory Tract Infections: A Cross-Sectional Study

Women are more often prescribed antibiotics than men for a number of health conditions. Adults’ behaviours in engagi...

Infectious Diseases And Therapy

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Protective Measures Taken in Residential Care Homes in England During the COVID-19 Pandemic. An Assessment of the Change in Mortality Rates Before and During the COVID-19 Pandemic Years

Mortality rate increased in the period after 1 January 2020 because of the Sars-Cov-2 (coronavirus disease 2019, COVID-19)...

Infectious Diseases And Therapy

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Colistin Sulfate-Based Combination Therapy for Infections Caused by Carbapenem-Resistant Organisms in Intensive Care Units: A Multicenter, Prospective, Observational Clinical Trial

With the rapid spread of carbapenem-resistant Gram-negative bacterial infections, polymyxins have reemerged as a critical ...

Infectious Diseases And Therapy

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Safety and Immunogenicity of Monovalent Omicron KP.2-Adapted BNT162b2 COVID-19 Vaccine in Adults: Single-Arm Substudy from a Phase 2/3 Trial

COVID-19 continues to cause substantial health burden, particularly among vulnerable populations. Vaccines remain a vital ...

Infectious Diseases And Therapy

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A Phase II, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of HEX17, a Novel Broad-Spectrum Antiviral Drug, in a Controlled Human Infection Model of Influenza Challenge

Viral respiratory tract infections are of global concern, with an unmet need for a broad-spectrum antiviral prophylactic. ...

Infectious Diseases And Therapy

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Stability of Ceftobiprole Medocaril in Portable Elastomeric Infusion Devices

Ceftobiprole medocaril is a new fifth-generation cephalosporin commercially available as a prodrug. Since it is newly intr...

Infectious Diseases And Therapy

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Syndemics of Antimicrobial Resistance: Non-communicable Diseases, Social Deprivation, and the Rise of Multidrug-Resistant Infections

Antimicrobial resistance (AMR) constitutes a global health emergency that results in significant morbidity, mortality, and...

Infectious Diseases And Therapy

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Use of Hyperbaric Oxygen in Patients with Necrotizing Soft Tissue Infections: A Scandinavian Multicenter, Prospective, Observational Cohort

Hyperbaric oxygen (HBO2) treatment is regularly used as adjuvant treatment in patients with necrotizing soft tissue infect...

Infectious Diseases And Therapy

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Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study

Caspofungin pharmacokinetics may be altered in critically ill patients. In vitro studies suggest significant drug adsorpti...

Infectious Diseases And Therapy

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Indirect Treatment Comparison of Long-Acting Injectable Cabotegravir as Pre-exposure Prophylaxis When Compared with no Pre-exposure Prophylaxis for HIV Prevention

The efficacy of long-acting injectable cabotegravir (hereafter referred to as cabotegravir) versus daily oral tenofovir di...

Infectious Diseases And Therapy

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Cost-Effectiveness Analysis of a Bivalent RSVPreF Vaccine in Japanese Adults Aged 60 Years and Older

Respiratory syncytial virus (RSV) is a major cause of acute respiratory illness. A bivalent RSV prefusion F protein-based ...

Infectious Diseases And Therapy

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Long-Term Real-World Use of Cabotegravir/Rilpivirine: Adherence and Virological Efficacy over a 44-Month Observation Period

Long-acting cabotegravir/rilpivirine (LA-CAB/RPV) offers an effective alternative to daily oral antiretroviral therapy (AR...

Infectious Diseases And Therapy

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Long-Term Impacts of Invasive Meningococcal Disease on Survivors and Their Caregivers in the United States and Canada

Adolescents and young adults are among those most often impacted by invasive meningococcal disease (IMD), and survivors ar...

Infectious Diseases And Therapy

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Budget Impact Analysis of Fecal Microbiota Spores, Live-brpk (Formerly SER-109) for Recurrent Infection in the United States

Fecal microbiota spores, live-brpk (hereafter VOS) is a microbiota-based orally administered therapeutic approved by the U...

Infectious Diseases And Therapy

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Impact of Metabolic Dysfunction-Associated Fatty Liver Disease of Varying Severity on Antiviral Treatment Outcomes and Clinical Prognosis in Patients with Chronic Hepatitis B: A Systematic Review and Meta-analysis

The coexistence of hepatitis B virus (HBV) infection and metabolic dysfunction-associated fatty liver disease (MAFLD) is b...

Infectious Diseases And Therapy

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Detection of SARS-CoV-2 in Settings Including Point-of-Care: Performance of the Cobas SARS-CoV-2 NAT and Utility with the Cobas Liat System

There is a need to confirm the diagnostic performance of point-of-care (POC) testing for severe acute respiratory coronavi...

Infectious Diseases And Therapy

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Impact of the COVID-19 pandemic on the regional epidemiology of methicillin-resistant Staphylococcus aureus in the Kumamoto region