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Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches
G-Protein-Coupled Receptors (GPCRs) make up around 3–4% of the human genome and are the targets of one-third of FDA-...
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display
One of the main challenges with many cancer immunotherapies is that biomarkers are needed for targeting. These biomarkers ...
Voltage Gated Ion Channels and Sleep
Voltage Gated Ion Channels and Sleep
Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal...
Correlation Between Antimicrobial Structural Classes and Membrane Partitioning: Role of Emerging Lipid Packing Defects
Correlation Between Antimicrobial Structural Classes and Membrane Partitioning: Role of Emerging Lipid Packing Defects
In this study, a combination of bioinformatics and molecular dynamics simulations is employed to investigate the partition...
Feasibility Study for the Use of Gene Electrotransfer and Cell Electrofusion as a Single-Step Technique for the Generation of Activated Cancer Cell Vaccines
Feasibility Study for the Use of Gene Electrotransfer and Cell Electrofusion as a Single-Step Technique for the Generation of Activated Cancer Cell Vaccines
Cell-based therapies hold great potential for cancer immunotherapy. This approach is based on manipulation of dendritic ce...
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies
Electrophysiology typically deals with the electrical properties of excitable cells like neurons and muscles. However, all...
Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders
Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders
TRPM8 is a non-selective cation channel that is expressed in several tissues and cells and also has a unique property to b...
Interaction of an Oomycete Nep1-like Cytolysin with Natural and Plant Cell-Mimicking Membranes
Interaction of an Oomycete Nep1-like Cytolysin with Natural and Plant Cell-Mimicking Membranes
Plants are attacked by various pathogens that secrete a variety of effectors to damage host cells and facilitate infection...
Hetero-Oligomeric Protein Pores for Single-Molecule Sensing
Hetero-Oligomeric Protein Pores for Single-Molecule Sensing
Protein nanopores are emerging as versatile single-molecule sensors with broad applications in DNA and protein sequencing....
Dengue Virus Fusion Peptide Promotes Hemifusion Formation by Disordering the Interfacial Region of the Membrane
Dengue Virus Fusion Peptide Promotes Hemifusion Formation by Disordering the Interfacial Region of the Membrane
Membrane fusion is the first step in the infection process of the enveloped viruses. Enveloped viruses fuse either at the ...
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes
The purpose of this work is to examine how triterpenoids betulin (BE) and betulinic acid (BA) affect the thermotropic phas...
Computational Insights on the Assembly of the Dengue Virus Membrane–Capsid–RNA Complex
Computational Insights on the Assembly of the Dengue Virus Membrane–Capsid–RNA Complex
Dengue virus, an arbovirus from the genus Flavivirus in the family Flaviviridae, forms a nucleocapsid structure through in...
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance
In this work, the heterodimeric phospholipase A2, HDP-2, from viper venom was investigated for its hydrolytic activity in ...
Pharmacodynamic characterization and evaluation of oxidative stress effects of digitoxigenin derivatives on HeLa cells
Pharmacodynamic characterization and evaluation of oxidative stress effects of digitoxigenin derivatives on HeLa cells
Cancer is a leading cause of death worldwide and its treatment is hampered by the lack of specificity and side effects of ...
The Role of the Swollen State in Cell Proliferation
The Role of the Swollen State in Cell Proliferation
Cell swelling is known to be involved in various stages of the growth of plant cells and microorganisms but in mammalian c...
Structural Dynamics of the Slide Helix of Inactive/Closed Conformation of KirBac1.1 in Micelles and Membranes: A Fluorescence Approach
Structural Dynamics of the Slide Helix of Inactive/Closed Conformation of KirBac1.1 in Micelles and Membranes: A Fluorescence Approach
Inward rectifying potassium (Kir) channels play a critical role in maintaining the resting membrane potential and cellular...
Gamma-Aminobutyric Acid Action on Membrane and Electrical Properties of Synaptosomes and Model Lipid Bilayers
Gamma-Aminobutyric Acid Action on Membrane and Electrical Properties of Synaptosomes and Model Lipid Bilayers
Dysfunction of the main inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is the underlying reason behind many ne...
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein
Neurological diseases refer to pathological changes that occur in the brain, spinal cord, and peripheral nerves. Their eti...
Vitamin D status and its determinants in German elite athletes
Vitamin D status and its determinants in German elite athletes
This study investigated elite German athletes to (1) assess their serum 25(OH)D levels and the prevalence of insufficiency...
Influence of deception of task duration on the sex-specific physiological responses to RPE-clamp cycle ergometry
Influence of deception of task duration on the sex-specific physiological responses to RPE-clamp cycle ergometry
The purpose of this study was to examine the sex-specific influence of expected exercise duration on the physiological res...
The effect of exercise and physical activity on skeletal muscle epigenetics and metabolic adaptations
The effect of exercise and physical activity on skeletal muscle epigenetics and metabolic adaptations
Physical activity (PA) and exercise elicit adaptations and physiological responses in skeletal muscle, which are advantage...
Cardiac adaptations in young triathletes: a 9-month longitudinal study during the peak height velocity period
Cardiac adaptations in young triathletes: a 9-month longitudinal study during the peak height velocity period
The present study examined the influence of endurance training on the morphological and functional heart adaptations in yo...
The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity
The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity
The aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflam...
The associations between cardiovascular and pain responses to a cold pressor test differ between males and females
The associations between cardiovascular and pain responses to a cold pressor test differ between males and females
Nociceptors contribute to the cardiovascular responses during a cold pressor test (CPT). While these responses are lower i...
Impact loading exercise induced osteogenesis from childhood to early adulthood in tennis players aged 8–30 years
Impact loading exercise induced osteogenesis from childhood to early adulthood in tennis players aged 8–30 years
Osteogenesis with impact-loading exercise is often assessed by the extra bone growth induced in the loaded arm of tennis p...
Skeletal muscle elastic modulus in marathon distance runners
Skeletal muscle elastic modulus in marathon distance runners
Skeletal muscle shear elastic modulus is a non-invasive surrogate for early detection of muscle damage and soreness conseq...
Conceptualizing a load and volume autoregulation integrated velocity model to minimize neuromuscular fatigue and maximize neuromuscular adaptations in resistance training
Conceptualizing a load and volume autoregulation integrated velocity model to minimize neuromuscular fatigue and maximize neuromuscular adaptations in resistance training
Resistance training (RT) load and volume are considered crucial variables to appropriately prescribe and manage for elicit...
Effects of 24-h sleep deprivation on whole-body heat exchange in young men during exercise in the heat
Effects of 24-h sleep deprivation on whole-body heat exchange in young men during exercise in the heat
Sleep deprivation has been associated with impaired thermoregulatory function. However, whether these impairments translat...
Acute changes in diffusion tensor imaging parameters of the quadriceps femoris muscle after stretching and their relationship with intramuscular adipose tissue
Acute changes in diffusion tensor imaging parameters of the quadriceps femoris muscle after stretching and their relationship with intramuscular adipose tissue
Whether stretch exercise improves muscle anisotropy in relation to intramuscular adipose tissue (IntraMAT) is unclear. Thi...
Rethinking exercise intensity prescription in continuous endurance exercise
Rethinking exercise intensity prescription in continuous endurance exercise
Effective targeting of specific training outcomes requires the careful selection and ...
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