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Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro
Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro
To explore the potential of KXD in mitigating gap junction remodeling and apoptosis in DCM and to elucidate the complex mo...
Ursolic Acid Ameliorates Diabetic Nephropathy by Inhibiting JAK2/STAT3-Driven Ferroptosis: Mechanistic Insights from Network Pharmacology and Experimental Validation
Ursolic Acid Ameliorates Diabetic Nephropathy by Inhibiting JAK2/STAT3-Driven Ferroptosis: Mechanistic Insights from Network Pharmacology and Experimental Validation
Exploring the underlying mechanism of UA protection against DN by blocking JAK2/STAT3-mediated ferroptosis. Read more
Comparison of Oliceridine and Morphine in Postoperative Analgesia in Laparoscopic Total Hysterectomy, a Randomized Double-Blind Controlled Trial
Comparison of Oliceridine and Morphine in Postoperative Analgesia in Laparoscopic Total Hysterectomy, a Randomized Double-Blind Controlled Trial
To identify safer and more effective postoperative analgesic methods for patients undergoing laparoscopic total hysterecto...
Synergistic Potential of Trikatu Essential Oil as an Aromatherapy Agent: A Chemical and Mechanistic Review
Synergistic Potential of Trikatu Essential Oil as an Aromatherapy Agent: A Chemical and Mechanistic Review
Reviewing the antioxidant, anti-inflammatory, anxiolytic, and neuroprotective properties of the bioactive compounds in Tri...
Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Controlled Trial
Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Controlled Trial
Evaluating remimazolam-propofol with flumazenil reversal on the emergence time and hemodynamics of patients undergoing lap...
Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling
Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling
We comprehensively examine contemporary research investigating the correlation between miRNAs and anti-tumor TCMs alongsid...
Phase I Trial of Pegylated Liposomal Doxorubicin Combined with Ifosfamide for Advanced Soft Tissue Sarcoma
Phase I Trial of Pegylated Liposomal Doxorubicin Combined with Ifosfamide for Advanced Soft Tissue Sarcoma
This phase I study aimed to determine the MTD and to assess the safety of escalated doses of PLD in combination with a fix...
Stimuli-Responsive Drug Delivery Systems for Enhanced Melanoma Immunotherapy
Stimuli-Responsive Drug Delivery Systems for Enhanced Melanoma Immunotherapy
To clarify how stimuli-responsive DDSs enhance melanoma immunotherapy and guide their use as therapeutic agents. Read more
Determining the Preventive Effect of Topical Magnesium Sulfate Administration on Postoperative Sore Throat [Letter]
Determining the Preventive Effect of Topical Magnesium Sulfate Administration on Postoperative Sore Throat [Letter]
Letter for the article Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for th...
Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000–May 2024). Trends, Collaborations, and Emerging Insights
Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000–May 2024). Trends, Collaborations, and Emerging Insights
The present study was conducted to provide a systematic bibliometric analysis of research trends related to SCI and exosomes.
Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling
Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling
Revealing that the Wel could alleviate ischemic stroke by inhibiting oxidative damage and ferroptosis via HIF-1α/ SL...
Model Prediction of Infection Risk After Glucocorticoid Treatment for Severe Drug-Induced Liver Injury: Globulin is a Core Predictive Factor
Model Prediction of Infection Risk After Glucocorticoid Treatment for Severe Drug-Induced Liver Injury: Globulin is a Core Predictive Factor
This study developed a predictive model for infection after glucocorticoid therapy in patients with drug-induced liver inj...
Efficacy and Safety of Guben Kechuan Granules in the Treatment of Chronic Bronchitis: A Multi-Center and Randomized Controlled Trial
Efficacy and Safety of Guben Kechuan Granules in the Treatment of Chronic Bronchitis: A Multi-Center and Randomized Controlled Trial
Guben Kechuan Granules demonstrated significant efficacy and safety in CB management, alleviating clinical symptoms, reduc...
Danggui Buxue Decoction Alleviates Acute Hypoxia-Induced Sleep Disorders: Insights from in vivo and in silico Analyses
Danggui Buxue Decoction Alleviates Acute Hypoxia-Induced Sleep Disorders: Insights from in vivo and in silico Analyses
Danggui Buxue decoction as a promising candidate for mitigating AHISD through neuroprotective and anti-inflammatory mechan...
Thoracic Paravertebral Block with Liposomal Bupivacaine Versus Plain Bupivacaine in Patients Undergoing Thoracoscopic Lung Resection: A Randomized Controlled Study
Thoracic Paravertebral Block with Liposomal Bupivacaine Versus Plain Bupivacaine in Patients Undergoing Thoracoscopic Lung Resection: A Randomized Controlled Study
We designed a prospective, randomized controlled trial to compare the analgesic effectiveness of a thoracic paravertebral ...
Intranasal Esketamine Premedication Reduces Sevoflurane Requirements During Laryngeal Mask Airway Insertion in Pediatric Patients: A Randomized Controlled Trial
Intranasal Esketamine Premedication Reduces Sevoflurane Requirements During Laryngeal Mask Airway Insertion in Pediatric Patients: A Randomized Controlled Trial
This study evaluated whether intranasal esketamine premedication reduces sevoflurane requirements for laryngeal mask airwa...
Analysis of Blood Components and Target Prediction for the Combined Use of Dendrobium officinale Compound and Western Medicine in Antihypertensive Therapy Based on Network Pharmacology and Molecular Docking
Analysis of Blood Components and Target Prediction for the Combined Use of Dendrobium officinale Compound and Western Medicine in Antihypertensive Therapy Based on Network Pharmacology and Molecular Docking
Investigating the primary monomer components and the associated mechanisms of action of DOC in exerting antihypertensive e...
Xian Huang Fang Inhibits the PKCδ/MAPK Signaling Pathway to Attenuate Renal Tubular Epithelial Cell Senescence and Thereby Delay Renal Interstitial Fibrosis
Xian Huang Fang Inhibits the PKCδ/MAPK Signaling Pathway to Attenuate Renal Tubular Epithelial Cell Senescence and Thereby Delay Renal Interstitial Fibrosis
The objective of this study was to investigate the protective effects of Xian Huang Fang against renal fibrosis and the un...
Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects
Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects
To provide readers with a systematic review of the mechanisms of action and clinical applications of Palmitoylethanolamide...
Impact of Remimazolam on Postoperative Delirium in Elderly Non-Cardiac Surgery Patients Admitted to the ICU: A Retrospective Propensity Score Matched Study
Impact of Remimazolam on Postoperative Delirium in Elderly Non-Cardiac Surgery Patients Admitted to the ICU: A Retrospective Propensity Score Matched Study
This study selected patients who were transferred to the ICU postoperatively for evaluation, as the enhanced monitoring in...
Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications
Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications
Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, inclu...
Advanced RPL19-TRAP-seq method reveals mechanism of action of bioactive compounds
Advanced RPL19-TRAP-seq method reveals mechanism of action of bioactive compounds
Natural products play a crucial role in new drug development, but their druggability is often limited by uncertain molecul...
Emestrin-type epipolythiodioxopiperazines from with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways
Emestrin-type epipolythiodioxopiperazines from with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways
Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C−G (1–5), along with two known E...
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of
Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid g...
Newly isolated terpenoids (covering 2019–2024) from species and their potential for the discovery of novel antimicrobials
Newly isolated terpenoids (covering 2019–2024) from species and their potential for the discovery of novel antimicrobials
The rapid emergence of drug-resistant microbial pathogens has posed challenges to global health in the twenty-first centur...
Vibralactone derivatives isolated from co-cultures of the basidiomycetes and
Vibralactone derivatives isolated from co-cultures of the basidiomycetes and
The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical inve...
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A
Natural product pseudolaric acid A (PAA), the main bioactive component from Traditional Chinese Medicine Pseudolarix corte...
Structurally diverse polyketides and alkaloids produced by a plant-derived fungus L1
Structurally diverse polyketides and alkaloids produced by a plant-derived fungus L1
A series of structurally diverse polyketides (1–3), sesterterpenoids (24 and 25), and alkaloids (26–34) were i...
Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus sp. Y01
Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus sp. Y01
Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their...
Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation
Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation
Salt-inducible kinase 1 (SIK1) participates in various physiological processes, yet its involvement in regulating skeletal...
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