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Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications
Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications
Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, inclu...
Advanced RPL19-TRAP-seq method reveals mechanism of action of bioactive compounds
Advanced RPL19-TRAP-seq method reveals mechanism of action of bioactive compounds
Natural products play a crucial role in new drug development, but their druggability is often limited by uncertain molecul...
Emestrin-type epipolythiodioxopiperazines from with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways
Emestrin-type epipolythiodioxopiperazines from with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways
Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C−G (1–5), along with two known E...
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of
Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid g...
Newly isolated terpenoids (covering 2019–2024) from species and their potential for the discovery of novel antimicrobials
Newly isolated terpenoids (covering 2019–2024) from species and their potential for the discovery of novel antimicrobials
The rapid emergence of drug-resistant microbial pathogens has posed challenges to global health in the twenty-first centur...
Vibralactone derivatives isolated from co-cultures of the basidiomycetes and
Vibralactone derivatives isolated from co-cultures of the basidiomycetes and
The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical inve...
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A
Natural product pseudolaric acid A (PAA), the main bioactive component from Traditional Chinese Medicine Pseudolarix corte...
Structurally diverse polyketides and alkaloids produced by a plant-derived fungus L1
Structurally diverse polyketides and alkaloids produced by a plant-derived fungus L1
A series of structurally diverse polyketides (1–3), sesterterpenoids (24 and 25), and alkaloids (26–34) were i...
Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus sp. Y01
Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus sp. Y01
Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their...
Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation
Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation
Salt-inducible kinase 1 (SIK1) participates in various physiological processes, yet its involvement in regulating skeletal...
Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy
Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy
Natural products obtained from medicinal and aromatic plants are increasingly recognized as promising anticancer agents du...
Phthalide mono- and dimers from the rhizomes of and their anti-inflammatory activities
Phthalide mono- and dimers from the rhizomes of and their anti-inflammatory activities
Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide m...
Inhibitory effects of corylin derived from aerial part of on melanin synthesis and potential applications in skin whitening and photoaging management
Inhibitory effects of corylin derived from aerial part of on melanin synthesis and potential applications in skin whitening and photoaging management
This study aimed to investigate the potential of corylin, a bioactive compound isolated from the aerial part of Pueraria l...
Rational search for natural antimicrobial compounds: relevance of sesquiterpene lactones
Rational search for natural antimicrobial compounds: relevance of sesquiterpene lactones
Antimicrobial resistance is one of the most pressing global health challenges, as many pathogens are rapidly evolving to e...
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus 11134
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus 11134
Sesquiterpenoids represent a structurally diverse class of natural products widely recognized for their ecological signifi...
Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by L. saponins: a new approach for the treatment of -induced bacterial keratitis
Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by L. saponins: a new approach for the treatment of -induced bacterial keratitis
Pseudomonas aeruginosa-induced bacterial keratitis is one of the most sight-threatening corneal infections associated with...
Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit
Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit
Two concise and efficient synthetic routes were developed for the synthesis of three 1,7-diarylheptanoids (1–3) cont...
Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Maxim
Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Maxim
In this work, six pairs of undescribed enantiomeric prenylated flavonoids, ( ±)-epimesatines J–O (1a/1b&#...
Enantiomeric diarylheptanoids from var. and their -glucosidase inhibitory activity
Enantiomeric diarylheptanoids from var. and their -glucosidase inhibitory activity
Otteacumienes G–K (1–5), five pairs of enantiomeric diarylheptanoids, along with one undescribed diarylheptano...
Polyprenylated acylphloroglucinols from species and structural revision of seven analogues
Polyprenylated acylphloroglucinols from species and structural revision of seven analogues
Our continuous study of the fruits of Garcinia xanthochymus and Garcinia subelliptica led to the isolation and structural ...
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Plants and microbes are closely associated with each other in their ecological niches. Much has been studied about plant&#...
Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations
Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations
Ulcerative colitis (UC) is a recurring autoimmune disorder characterized by persistent inflammation in the mucosal lining ...
Correction: Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Correction: Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Following publication of the original article [1], the authors reported that the original version of this article unfortun...
Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress
Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress
Triplostegia glandulifera Wall (T. glandulifera) is an ethnomedicine commonly used by ethnic minorities in Yunnan, China, ...
Natural and revolutionary tumor-specific T-cell therapy
Natural and revolutionary tumor-specific T-cell therapy
Recently the FDA conducted a risk investigation and labeled the Boxed Warning for all BCMA- and CD19-directed CAR-T cell t...
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Biotransformation is a process in which molecules are modified in the presence of a biocatalyst or enzymes, as well as the...
Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications
Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications
Arctium lappa, widely recognized as burdock, is a perennial plant that is employed in the realm of traditional Chinese med...
Purification and immobilization of β-glucosidase using surface modified mesoporous silica Santa Barbara Amorphous 15 for eco-friendly preparation of sagittatoside A
Purification and immobilization of β-glucosidase using surface modified mesoporous silica Santa Barbara Amorphous 15 for eco-friendly preparation of sagittatoside A
Functionalized mesoporous materials have become a promising carrier for enzyme immobilization. In this study, Santa Barbar...
Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family
Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family
Apicidins are a class of naturally occurring cyclic tetrapeptides produced by few strains within the Fusarium genus. These...
Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata
Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata
Dictyophora rubrovalvata is a valuable fungus homologous to food and medicine, and its polysaccharide have been gaining in...
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