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SCI Abstract
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Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro
To explore the potential of KXD in mitigating gap junction remodeling and apoptosis in DCM and to elucidate the complex mo...
Drug Design Development And Therapy
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Ursolic Acid Ameliorates Diabetic Nephropathy by Inhibiting JAK2/STAT3-Driven Ferroptosis: Mechanistic Insights from Network Pharmacology and Experimental Validation
Exploring the underlying mechanism of UA protection against DN by blocking JAK2/STAT3-mediated ferroptosis. Read more
Drug Design Development And Therapy
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Comparison of Oliceridine and Morphine in Postoperative Analgesia in Laparoscopic Total Hysterectomy, a Randomized Double-Blind Controlled Trial
To identify safer and more effective postoperative analgesic methods for patients undergoing laparoscopic total hysterecto...
Drug Design Development And Therapy
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Synergistic Potential of Trikatu Essential Oil as an Aromatherapy Agent: A Chemical and Mechanistic Review
Reviewing the antioxidant, anti-inflammatory, anxiolytic, and neuroprotective properties of the bioactive compounds in Tri...
Drug Design Development And Therapy
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Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Controlled Trial
Evaluating remimazolam-propofol with flumazenil reversal on the emergence time and hemodynamics of patients undergoing lap...
Drug Design Development And Therapy
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Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling
We comprehensively examine contemporary research investigating the correlation between miRNAs and anti-tumor TCMs alongsid...
Drug Design Development And Therapy
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Phase I Trial of Pegylated Liposomal Doxorubicin Combined with Ifosfamide for Advanced Soft Tissue Sarcoma
This phase I study aimed to determine the MTD and to assess the safety of escalated doses of PLD in combination with a fix...
Drug Design Development And Therapy
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Stimuli-Responsive Drug Delivery Systems for Enhanced Melanoma Immunotherapy
To clarify how stimuli-responsive DDSs enhance melanoma immunotherapy and guide their use as therapeutic agents. Read more
Drug Design Development And Therapy
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Determining the Preventive Effect of Topical Magnesium Sulfate Administration on Postoperative Sore Throat [Letter]
Letter for the article Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for th...
Drug Design Development And Therapy
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Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000–May 2024). Trends, Collaborations, and Emerging Insights
The present study was conducted to provide a systematic bibliometric analysis of research trends related to SCI and exosomes.
Drug Design Development And Therapy
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Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling
Revealing that the Wel could alleviate ischemic stroke by inhibiting oxidative damage and ferroptosis via HIF-1α/ SL...
Drug Design Development And Therapy
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Model Prediction of Infection Risk After Glucocorticoid Treatment for Severe Drug-Induced Liver Injury: Globulin is a Core Predictive Factor
This study developed a predictive model for infection after glucocorticoid therapy in patients with drug-induced liver inj...
Drug Design Development And Therapy
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Efficacy and Safety of Guben Kechuan Granules in the Treatment of Chronic Bronchitis: A Multi-Center and Randomized Controlled Trial
Guben Kechuan Granules demonstrated significant efficacy and safety in CB management, alleviating clinical symptoms, reduc...
Drug Design Development And Therapy
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Danggui Buxue Decoction Alleviates Acute Hypoxia-Induced Sleep Disorders: Insights from in vivo and in silico Analyses
Danggui Buxue decoction as a promising candidate for mitigating AHISD through neuroprotective and anti-inflammatory mechan...
Drug Design Development And Therapy
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Thoracic Paravertebral Block with Liposomal Bupivacaine Versus Plain Bupivacaine in Patients Undergoing Thoracoscopic Lung Resection: A Randomized Controlled Study
We designed a prospective, randomized controlled trial to compare the analgesic effectiveness of a thoracic paravertebral ...
Drug Design Development And Therapy
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Intranasal Esketamine Premedication Reduces Sevoflurane Requirements During Laryngeal Mask Airway Insertion in Pediatric Patients: A Randomized Controlled Trial
This study evaluated whether intranasal esketamine premedication reduces sevoflurane requirements for laryngeal mask airwa...
Drug Design Development And Therapy
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Analysis of Blood Components and Target Prediction for the Combined Use of Dendrobium officinale Compound and Western Medicine in Antihypertensive Therapy Based on Network Pharmacology and Molecular Docking
Investigating the primary monomer components and the associated mechanisms of action of DOC in exerting antihypertensive e...
Drug Design Development And Therapy
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Xian Huang Fang Inhibits the PKCδ/MAPK Signaling Pathway to Attenuate Renal Tubular Epithelial Cell Senescence and Thereby Delay Renal Interstitial Fibrosis
The objective of this study was to investigate the protective effects of Xian Huang Fang against renal fibrosis and the un...
Drug Design Development And Therapy
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Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects
To provide readers with a systematic review of the mechanisms of action and clinical applications of Palmitoylethanolamide...
Drug Design Development And Therapy
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Impact of Remimazolam on Postoperative Delirium in Elderly Non-Cardiac Surgery Patients Admitted to the ICU: A Retrospective Propensity Score Matched Study
This study selected patients who were transferred to the ICU postoperatively for evaluation, as the enhanced monitoring in...
Drug Design Development And Therapy
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The Effect of Intravenous Lidocaine on EC50 of Remifentanil for Preventing Cough During Emergence in Female for Thyroid Surgery Anesthesia
The effect of intravenous lidocaine on EC50 of remifentanil for preventing cough during emergence in female for thyroid su...
Drug Design Development And Therapy
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A Novel Quaternary Ammonium N-Propylamiodarone Bromide Provides Long-Lasting Analgesia Against Corneal Pain
N-propylamiodarone bromide (NPA) produced long-lasting analgesia against corneal injury without hampering corneal recovery...
Drug Design Development And Therapy
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Effect of Position-Based Dosing Strategy for Metaraminol on Neonatal Acid–Base Status During Elective Caesarean Delivery: A Noninferiority Randomised Controlled Trial
A higher starting dose of metaraminol in the supine position will result in a non-inferior umbilical arterial pH compared ...
Drug Design Development And Therapy
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The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial [Response to Letter]
Response to Letter in regards to The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with G...
Drug Design Development And Therapy
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Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients
A large between subject variability for clearance was best presented by the large variability in vancomycin trough concent...
Drug Design Development And Therapy
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Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury
Investigating the effects of Curcumin on acute kidney injury ferroptosis.
Drug Design Development And Therapy
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Using Network Pharmacology and in vivo Experiments to Uncover the Mechanisms of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules in Treating Diabetes Mellitus-Induced Erectile Dysfunction
The mechanisms and targets of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules (RAG) in treating DMED using netw...
Drug Design Development And Therapy
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Comprehensive Assessment of PCSK9 Inhibitors for Lipid Management: Scientific Guidance Based on Drug Selection Recommendations for Chinese Medical Institutions
This study evaluated four pcsk9 inhibitors: evolocumab, alirocumab, inclisiran & tafolecimab marketed in China by usin...
Drug Design Development And Therapy
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Unveiling the Mechanisms and Therapeutic Effects of Xiaoyao Sanjie Decoction in Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Approach
Verifying the efficacy of Xiaoyao Sanjie Decoction and its active component in the treatment of TNBC and explored its pote...
Drug Design Development And Therapy
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External Validation of the Population Pharmacokinetic Models of Amisulpride and Remedial Strategies for Delayed or Missed Doses
Evaluating the predictive performance of published amisulpride population pharmacokinetic models in schizophrenia patients...
Drug Design Development And Therapy
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