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SCI Abstract
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The Effect of Intravenous Lidocaine on EC50 of Remifentanil for Preventing Cough During Emergence in Female for Thyroid Surgery Anesthesia
The effect of intravenous lidocaine on EC50 of remifentanil for preventing cough during emergence in female for thyroid su...
Drug Design Development And Therapy
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A Novel Quaternary Ammonium N-Propylamiodarone Bromide Provides Long-Lasting Analgesia Against Corneal Pain
N-propylamiodarone bromide (NPA) produced long-lasting analgesia against corneal injury without hampering corneal recovery...
Drug Design Development And Therapy
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Effect of Position-Based Dosing Strategy for Metaraminol on Neonatal Acid–Base Status During Elective Caesarean Delivery: A Noninferiority Randomised Controlled Trial
A higher starting dose of metaraminol in the supine position will result in a non-inferior umbilical arterial pH compared ...
Drug Design Development And Therapy
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The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial [Response to Letter]
Response to Letter in regards to The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with G...
Drug Design Development And Therapy
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Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients
A large between subject variability for clearance was best presented by the large variability in vancomycin trough concent...
Drug Design Development And Therapy
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Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury
Investigating the effects of Curcumin on acute kidney injury ferroptosis.
Drug Design Development And Therapy
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Using Network Pharmacology and in vivo Experiments to Uncover the Mechanisms of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules in Treating Diabetes Mellitus-Induced Erectile Dysfunction
The mechanisms and targets of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules (RAG) in treating DMED using netw...
Drug Design Development And Therapy
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Comprehensive Assessment of PCSK9 Inhibitors for Lipid Management: Scientific Guidance Based on Drug Selection Recommendations for Chinese Medical Institutions
This study evaluated four pcsk9 inhibitors: evolocumab, alirocumab, inclisiran & tafolecimab marketed in China by usin...
Drug Design Development And Therapy
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Unveiling the Mechanisms and Therapeutic Effects of Xiaoyao Sanjie Decoction in Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Approach
Verifying the efficacy of Xiaoyao Sanjie Decoction and its active component in the treatment of TNBC and explored its pote...
Drug Design Development And Therapy
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External Validation of the Population Pharmacokinetic Models of Amisulpride and Remedial Strategies for Delayed or Missed Doses
Evaluating the predictive performance of published amisulpride population pharmacokinetic models in schizophrenia patients...
Drug Design Development And Therapy
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Oxyresveratrol Alleviates Irinotecan-Induced Diarrhea and Enhances Antitumor Effects in Colorectal Cancer
Whether OXY can alleviate CPT-11-induced intestinal toxicity and whether the combination of these 2 drugs can enhance the ...
Drug Design Development And Therapy
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Tomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2/HO-1/GPX4 Signaling Pathway
Tomatidine is a promising candidate for Intervertebral disc degeneration treatment.
Drug Design Development And Therapy
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Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway
MZGW-H effectively ameliorates OVX-induced osteoporosis partially achieved by increasing SCFAs metabolism and modulating t...
Drug Design Development And Therapy
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CXCR2 Activated JAK3/STAT3 Signaling Pathway Exacerbating Hepatotoxicity Associated with Tacrolimus
Blocking CXCR2 could reverse the expression of p-JAK3/p-STAT3, CIS, PIM1, and tacrolimus-induced hepatotoxicity. Read more.
Drug Design Development And Therapy
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Garlic-Derived Quorum Sensing Inhibitors: A Novel Strategy Against Fungal Resistance
Garlic, widely utilized in traditional medicine, is frequently selected as a primary treatment for preventing and managing...
Drug Design Development And Therapy
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Dosing Regimen Recommendations for Sirolimus in Adult Liver Transplant Recipients: Insights from a Population Pharmacokinetic Model
Performing population pharmacokinetic analysis of sirolimus in adult liver transplant recipients, developing dosing regime...
Drug Design Development And Therapy
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Qingre Huoxue Decoction Alleviates Atherosclerosis by Regulating Macrophage Polarization Through Exosomal miR-26a-5p
Investigating the effects of Qingre Huoxue Decoction on atherosclerosis and explore the underlying mechanisms.
Drug Design Development And Therapy
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Baolier Capsule’s Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis
to investigate the pharmacological effects, principal active ingredients, and mechanisms of BLEC against hypercholesterole...
Drug Design Development And Therapy
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Comparison of Remimazolam-Flumazenil and Propofol on Psychomotor Function and Emergence Following General Anesthesia in Surgical Abortion: A Randomized Controlled Trial
This study addresses this gap by comparing the psychomotor recovery and emergence profiles of remimazolam combined with fl...
Drug Design Development And Therapy
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Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Ruta graveolens L.: A Critical Review and Future Perspectives
Medicinal plants are sources of natural products with high chemical diversity and specificity as novel lead compounds with...
Drug Design Development And Therapy
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Huangqi-Danshen Decoction Against Renal Fibrosis in UUO Mice via TGF-β1 Induced Downstream Signaling Pathway
To uncover the underlying mechanism of HDD antagonizing renal fibrosis through NP analysis and experimental validation. Re...
Drug Design Development And Therapy
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Feasibility and Safety of PD-1 Blockades Among Elderly Patients with Metastatic Esophageal Squamous Cell Carcinoma: A Real-World Study
To identify the effectiveness and safety of PD-1 blockades among elderly patients with metastatic esophageal squamous cell...
Drug Design Development And Therapy
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Revisiting Niclosamide Formulation Approaches – a Pathway Toward Drug Repositioning
Endeavors made to enhance the water solubility & consequently the bioavailability of NIC, considering various formulat...
Drug Design Development And Therapy
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Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization
GXNT intervention exerts a beneficial effect against post-IS injury via regulating complement & coagulation cascades p...
Drug Design Development And Therapy
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Ozone Administration Reduces Myocardial Ischemia Reperfusion Injury in Streptozotocin Induced Diabetes Mellitus Rat Model
To demonstrate whether ozone has cardioprotective effects on the myocardial IRI in rats with STZ-induced diabetes
Drug Design Development And Therapy
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Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches
Here, we review the pathogenesis of cytokine storms and the mechanisms and pathways that establish the connection between ...
Drug Design Development And Therapy
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Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis
Targets, pathways, and mechanisms of Schisandrin B (Sch B) in alleviating renal ischemia-reperfusion injury (RIRI) using R...
Drug Design Development And Therapy
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New Perspectives on Obesity-Associated Nephropathy from Pathophysiology to Therapeutics: Revealing the Promise of GLP-1 RA Therapy
A consolidation of recent strides in the pathophysiology, diagnosis and therapeutic strategies for ORN (obesity-associated...
Drug Design Development And Therapy
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An Evaluation of Amoxicillin/Clavulanate Stability in Aqueous Systems, Including Its Suitability for Outpatient Parenteral Antimicrobial Therapy (OPAT)
An Evaluation of Amoxicillin/Clavulanate Stability in Aqueous Systems, Including Its Suitability for Outpatient Parenteral...
Drug Design Development And Therapy
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Combining Metagenomics, Network Pharmacology and RNA-Seq Strategies to Reveal the Therapeutic Effects and Mechanisms of Qingchang Wenzhong Decoction on Inflammatory Bowel Disease in Mice
We aimed to probe the mechanism of Qingchang Wenzhong Decoction for the treatment of inflammatory bowel disease.
Drug Design Development And Therapy
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