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A new diterpenoid, carneadiol, isolated from IFM 12324
A new diterpenoid, carneadiol, isolated from IFM 12324
A new diterpenoid, carneadiol (1), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts...
Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation
Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation
Since the coronavirus disease 2019 (COVID-19) outbreak, research has been conducted on treatment and countermeasures again...
Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases
Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases
Fe(II)/αKG-dependent oxygenases are multifunctional oxidases responsible for the formation of unique natural product ...
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from seeds
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from seeds
Resin glycosides, characteristic of plants of the Convolvulaceae family, are well-known purgative constituents found in tr...
Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway
Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway
Boletus bicolor is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 fr...
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of
Two previously undescribed specialized metabolites, erecricins F (1) and G (2), along with two known metabolites, erectumi...
SIRT5: a potential target for discovering bioactive natural products
SIRT5: a potential target for discovering bioactive natural products
Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mi...
Potential -glucosidase inhibitors from cultures of SWUF15-40 fungus
Potential -glucosidase inhibitors from cultures of SWUF15-40 fungus
The search for a potent α-glucosidase inhibitor from the fungus Biscogniauxia capnodes SWUF15-40 yielded eighteen com...
New abietane-type diterpenoids from roots of and their cytotoxicity in human cancer cell
New abietane-type diterpenoids from roots of and their cytotoxicity in human cancer cell
Two new abietane-type diterpenoids, 6β-(3-furoyloxy)ferruginol (1) and 6-chloro-6,7-dehydroferruginol (2), were isola...
Grandifolins A–D: three 6/6/5 abietane diterpenes and an abietane diterpene from
Grandifolins A–D: three 6/6/5 abietane diterpenes and an abietane diterpene from
The genus Salvia is a well-established source of biologically active compounds with beneficial health effects. In this stu...
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline -oxides from the aerial parts of as potential COX-2 inhibitors: in vitro and in silico studies
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline -oxides from the aerial parts of as potential COX-2 inhibitors: in vitro and in silico studies
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides, were isolated from the aerial parts of Leptopy...
Growth characteristics, optimal harvest timing, and quality assessment of three species cultivated in Japan
Growth characteristics, optimal harvest timing, and quality assessment of three species cultivated in Japan
Immature Evodia fruits are used in herbal medicine for their analgesic properties; however, determining the appropriate ti...
New oxepin and dihydrobenzofuran derivatives from roots and their anti-inflammatory, cytotoxic, and antioxidant activities
New oxepin and dihydrobenzofuran derivatives from roots and their anti-inflammatory, cytotoxic, and antioxidant activities
Four new oxepin and dihydrobenzofuran derivatives, saccoxepins A–C (1–3) and saccobenzofurin A (4), along with...
Correlation between the metabolic profile of Nelumbo Seed, a component of Seishinrenshiin, and its inhibitory activity on bladder smooth muscle contraction
Correlation between the metabolic profile of Nelumbo Seed, a component of Seishinrenshiin, and its inhibitory activity on bladder smooth muscle contraction
Seishinrenshiin (SRI), a Kampo formula, is often used for frequent urination. Nelumbo Seed, a crude-drug component of SRI ...
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in
Aconitum japonicum, native to the mountainous regions of Japan, is a toxic perennial plant widely recognized for its thera...
Extraction, characterization, and biological activities of a novel polysaccharide extract from
Extraction, characterization, and biological activities of a novel polysaccharide extract from
This study showed that Polysaccharide-rich Fructus caryophylli extracts (FCE) were prepared for investigation through hot ...
Amide and phenylpropanoid glycosides from the fruits of L. and their anti-inflammatory activity
Amide and phenylpropanoid glycosides from the fruits of L. and their anti-inflammatory activity
Ten glycosidic compounds (1–10), including two novel amide glycosides and one new phenylpropanoid glycoside, were is...
Berberine diminishes the malignant progression of non-small cell lung cancer cells by targeting CDCA5 and CCNA2
Berberine diminishes the malignant progression of non-small cell lung cancer cells by targeting CDCA5 and CCNA2
Berberine (BBR), an isoquinoline alkaloid from Coptidis Rhizoma, possesses powerful activities against diverse human malig...
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Two new lindenane-type sesquiterpenoid dimers, chlotrichenes C and D (1 and 2) together with five known lindenane-type ses...
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities
A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of five new pimarane diterpenes, ...
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China
Menthae Herba is an herbal medicine whose name is written with the same kanji characters (薄荷) in both the Ja...
Study on the chemical composition and anti-fungi activities of anthraquinones and its glycosides from Rumex japonicus Houtt.
Study on the chemical composition and anti-fungi activities of anthraquinones and its glycosides from Rumex japonicus Houtt.
Fungi, such as Trichophyton rubrum (T. rubrum) and Microsporum canis Bodin Anamorph (M. canis Bodin Anamorph) are the main...
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways
Previously, we reported that azamollugin, an aza-derivative of mollugin, exhibited potent inhibitory activity on NO produc...
Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit
Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit
Lysiphyllum binatum (Blanco) de Wit in the Fabaceae family, despite its traditional medicinal uses, has not been the subje...
Research on the quality evaluation of crude drugs
Research on the quality evaluation of crude drugs
As crude drugs are natural products, their quality may vary. However, the degradation of the active ingredients in the com...
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Epilepsy, characterized by recurrent seizures, often accompanies neurocognitive impairments and is associated with increas...
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
The inhibition of amyloid β (Aβ) aggregation and degradation of Aβ aggregates are promising approaches for ...
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Ferroptosis is a unique programmed cell death driven by iron-dependent phospholipid peroxidation. Tumor cells that escape ...
New sesquiterpenes from the soft coral Litophyton arboreum
New sesquiterpenes from the soft coral Litophyton arboreum
Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were...
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Currently, there are no effective prophylactic or therapeutic drugs for the treatment of paclitaxel (PTX)-induced peripher...
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