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Re-evaluating the relevance of extensive intraductal component (EIC) in modern breast cancer management
Re-evaluating the relevance of extensive intraductal component (EIC) in modern breast cancer management
The concept of extensive intraductal component (EIC), currently defined by the presence of a prominent ductal carcinoma in...
Real-time histological evaluation of gastrointestinal tissue using non-linear microscopy
Real-time histological evaluation of gastrointestinal tissue using non-linear microscopy
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Unravelling switch/sucrose non-fermentable (SWI-SNF) complex-deficient thoracic tumours: a clinicopathological comparative on undifferentiated tumours and non-small cell lung carcinomas with BRG1 and BRM deficiency
Unravelling switch/sucrose non-fermentable (SWI-SNF) complex-deficient thoracic tumours: a clinicopathological comparative on undifferentiated tumours and non-small cell lung carcinomas with BRG1 and BRM deficiency
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Computational pathology identifies a low B-cell content in the tumour microenvironment as a predictor of adverse outcome in patients with classic Hodgkin lymphoma treated with ABVD
Computational pathology identifies a low B-cell content in the tumour microenvironment as a predictor of adverse outcome in patients with classic Hodgkin lymphoma treated with ABVD
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Breast phyllodes tumour with epithelioid feature predisposes to malignant transformation
Breast phyllodes tumour with epithelioid feature predisposes to malignant transformation
WHAT IS ALREADY KNOWN ON THIS TOPICThe stromal cells of classic phyllodes tumour (PT) exhibit a spindle cell morphology, w...
Partial regression of conventional renal cell carcinoma displays markers of wound repair
Partial regression of conventional renal cell carcinoma displays markers of wound repair
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionSpontaneous regress...
Novel and unusual USP6 fusion partners in aneurysmal bone cyst and their role in pathogenesis and histopathological evaluation of this disease
Novel and unusual USP6 fusion partners in aneurysmal bone cyst and their role in pathogenesis and histopathological evaluation of this disease
IntroductionAneurysmal bone cyst (ABC) belongs to a heterogenous group of reactive and neoplastic processes collectively k...
Molecular profiling of visible polypoid and invisible conventional intestinal-type low-grade dysplasia in patients with idiopathic inflammatory bowel disease
Molecular profiling of visible polypoid and invisible conventional intestinal-type low-grade dysplasia in patients with idiopathic inflammatory bowel disease
Materials and methodsStudy groupsThe study population consisted of four groups of patients identified through a retrospect...
IASLC grading system predicts distant metastases for resected lung adenocarcinoma
IASLC grading system predicts distant metastases for resected lung adenocarcinoma
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Time trends in Gleason score distribution among Gleason score 8 and 9-10 cancers
Time trends in Gleason score distribution among Gleason score 8 and 9-10 cancers
Reporting of prostate cancer grade has drifted to higher reported grades over the past decades. In prostate cancers diagno...
9p24/JAK2 rearrangements in myeloid neoplasms: from myelodysplastic syndromes to myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions
9p24/JAK2 rearrangements in myeloid neoplasms: from myelodysplastic syndromes to myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions
Chromosomal translocations involving 9p24/JAK2 are rare genetic events, typically occurring in B-cell acute lymphoblastic ...
Retraction: Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis
Retraction: Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis
This article1 has been retracted by the Journal of Clinical Pathology due to apparent peer review manipulation.An individu...
Safety and efficacy of different rotational speed during rotational atherectomy in coronary heart disease patients (RACE): study protocol for a randomized controlled trial
Safety and efficacy of different rotational speed during rotational atherectomy in coronary heart disease patients (RACE): study protocol for a randomized controlled trial
The increasing incidence of coronary heart disease, driven by socio-economic development and population aging, poses signi...
Core outcome sets in cancer clinical trials: current status and future opportunities—an EORTC perspective
Core outcome sets in cancer clinical trials: current status and future opportunities—an EORTC perspective
Inconsistent, varied and selective outcome reporting is problematic in clinical trials. Core outcome sets (COS) standardis...
SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma
Research ArticleCell biologyOncologyStem cells Open Access | 10.1172/jci.insight.186344 Chuny...
Altered inflammatory mucosal signatures within their spatial and cellular context during active ileal Crohn’s disease
Research ArticleGastroenterologyInflammation Open Access | 10.1172/jci.insight.171783 Vasanth...
Permanent defects in renal medullary structure and function after reversal of urinary obstruction
Persistent decline in renal function and UCC To study the effects of prolonged ureteric obstruction on the kidney, male B...
Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma
Research ArticleGeneticsNeuroscienceOphthalmology Open Access | 10.1172/jci.insight.188710 Ba...
Multimodal integration of blood RNA and ctDNA reflects response to immunotherapy in metastatic urothelial cancer
Clinical Research and Public HealthImmunologyOncology Open Access | 10.1172/jci.insight.186062 ...
Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development
Aged neutrophil populations in menstrual effluent from women with endometriosis. Previous findings using our in vivo SDME...
Leveraging complementary multi-omics data integration methods for mechanistic insights in kidney diseases
Research ArticleNephrology Open Access | 10.1172/jci.insight.186070 Fadhl Alakwaa,1 Vivek...
Metabolic shifts in tryptophan pathways during acute pancreatitis infections
Research ArticleGastroenterology Open Access | 10.1172/jci.insight.186745 Daosheng Wang,1,2 ...
APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition
Research ArticleCell biologyOncology Open Access | 10.1172/jci.insight.186409 Jessica M. Deve...
Orchestrated response from heterogenous fibroblast subsets contributes to repair from surgery-induced stress after airway reconstruction
SIS results in Fb accumulation in the reconstructed airway. In our previous work, we showed that ECM turnover and remodel...
Fibroblast growth factor–inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair
Activation of Fn14 signaling in satellite cells during muscle regeneration. We first investigated how the expression of F...
The AURKA inhibitor alters the immune microenvironment and enhances targeting B7-H3 immunotherapy in glioblastoma
Increased B7-H3 expression in GBM and the correlation between AURKA and B7-H3. First, we investigated the differentially ...
A single-cell atlas of normal and KRASG12D-malformed lymphatic vessels
Sex as a biological variable. Our study examined male and female animals, and similar findings are reported for both sexe...
Characterization of cognitive decline in long-duration type 1 diabetes by cognitive, neuroimaging, and pathological examinations
Clinical Research and Public HealthAgingEndocrinology Open Access | 10.1172/jci.insight.180226 ...
Aerobic exercise prevents renal osteodystrophy via irisin-activated osteoblasts
Research ArticleBone biologyCell biologyMetabolism Open Access | 10.1172/jci.insight.184468 M...
NAD+ prevents chronic kidney disease by activating renal tubular metabolism
Research ArticleNephrology Open Access | 10.1172/jci.insight.181443 Bryce A. Jones,1 Debo...
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