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Drug discovery and development: the role of artificial intelligence in drug repurposing
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Future Medicinal Chemistry
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Design, synthesis and mechanistic study of new dual targeting HDAC/tubulin inhibitors
Aim: The purpose of this work is to create and synthesize a new class of chemicals: 3-cyano-2-substituted pyridine compoun...
Future Medicinal Chemistry
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Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors
Background: In Alzheimer’s disease, butyrylcholinesterase (BuChE) activity gradually increases, while acetylcholinesterase...
Future Medicinal Chemistry
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Exploring the antimicrobial and cytotoxic potential of novel chloroquine analogues
Aim: To synthesize novel chloroquine analogues and evaluate them for antimicrobial and cytotoxic potential. Methods: Novel...
Future Medicinal Chemistry
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Evaluation of novel synthesized thiazole derivatives as potential aromatase inhibitors against breast cancer
Background: 4-Methylacetophenone is used in the preparation of starting materials, 4-methylphenacyle bromide (2) and 4-met...
Future Medicinal Chemistry
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Novel 1,2,4-triazoles as selective carbonic anhydrase inhibitors showing ancillary anticathepsin B activity
Background: Exploration of the multi-target approach considering both human carbonic anhydrase (hCA) IX and XII and cathep...
Future Medicinal Chemistry
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The contemplation of amylose for the delivery of ulcerogenic nonsteroidal anti-inflammatory drugs
This manuscript proposes an innovative approach to mitigate the gastrointestinal adversities linked with nonsteroidal anti...
Future Medicinal Chemistry
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One-step synthesis of diaryloxadiazoles as potent inhibitors of BCRP
Aim: BCRP plays a major role in the efflux of cytotoxic molecules, limiting their antiproliferative activity. We aimed to ...
Future Medicinal Chemistry
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Design, synthesis and evaluation of new thiazolidin-4-ones as LPA1 receptor antagonists for breast cancer therapy
Aim: Breast cancer has been a leading cause of mortality among women worldwide in recent years. Targeting the lysophosphat...
Future Medicinal Chemistry
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PTSA-induced synthesis, in silico and nano study of novel ethylquinolin–thiazolo–triazole in cervical cancer
Aim: p-Toluenesulfonic acid-(PTSA) and grinding-induced novel synthesis of ethylquinolin–thiazolo–triazole derivatives was...
Future Medicinal Chemistry
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ProHES: hydroxyethyl starch's transformative role in anticancer drug delivery
The authors have no financial involvement with any organization or entity with a financial interest in or financial confli...
Future Medicinal Chemistry
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Design and synthesis of novel coumarin–benzimidazole hybrids as human galectin-1 inhibitors
Aim: To develop novel non-carbohydrate inhibitors of human galectin-1 (GAL-1), we have designed a series of coumarin–benzi...
Future Medicinal Chemistry
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Design, synthesis and biological evaluation of novel 3C-like protease inhibitors as lead compounds against SARS-CoV-2
Background: The epidemic caused by SARS-CoV-2 swept the world in 2019. The 3C-like protease (3CLpro) of SARS-CoV-2 plays a...
Future Medicinal Chemistry
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Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation
Background: Histone deacetylase inhibitors (HDACIs) are important as anticancer agents. Objective: This study aimed to inv...
Future Medicinal Chemistry
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The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids
Cancer as a devastating malignancy, seriously threatens human life and health, but most chemotherapeutics have long been c...
Future Medicinal Chemistry
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Synthesis, in vitro and in silico anticancer evaluation of novel pyridin-2-yl estra-1,3,5(10)-triene derivatives
Aim: The aim of this study was the synthesis of steroid compounds with heterocyclic rings and good anticancer properties. ...
Future Medicinal Chemistry
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Insight on novel oxindole conjugates adopting different anti-inflammatory investigations and quantitative evaluation
Background: A dual COX/5-LOX strategy was adopted to develop new oxindole derivatives with superior anti-inflammatory acti...
Future Medicinal Chemistry
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Application of parallel artificial membrane permeability assay technique and chemometric modeling for blood–brain barrier permeability prediction of protein kinase inhibitors
Aim: This study aims to investigate the passive diffusion of protein kinase inhibitors through the blood–brain barrier (BB...
Future Medicinal Chemistry
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Exploring of novel oxazolones and imidazolones as anti-inflammatory and analgesic candidates with cyclooxygenase inhibitory action
Aim: Over the last few decades, therapeutic needs have led to a search for safer COX-2 inhibitors with potential anti-infl...
Future Medicinal Chemistry
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Quinazoline sulfonamide derivatives targeting MicroRNA-34a/MDM4/p53 apoptotic axis with radiosensitizing activity
Aim: New quinazoline benzenesulfonamide hybrids 4a–n were synthesized to determine their cytotoxicity and effect on the mi...
Future Medicinal Chemistry
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Novel xylenyl-spaced bis-thiazoles/thiazines: synthesis, biological profile as herpes simplex virus type 1 inhibitors and in silico simulations
Aims: Development of some potent bis-thiazole and bis-thiazine derivatives that could be used as antiviral prototypes. Mat...
Future Medicinal Chemistry
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Novel benzimidazole derivatives as effective inhibitors of prolyl oligopeptidase: synthesis, in vitro and in silico analysis
Background: This research aims to discover novel derivatives having potential therapeutic applications in treating conditi...
Future Medicinal Chemistry
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In vitro cytotoxic investigation of some synthesized 1,6-disubstituted-1-azacoumarin derivatives as anticancer agents
Aims: In this study, novel synthesized 1,6-disubstituted-1-azacoumarin-3-carboxylic acid derivatives were designed, synthe...
Future Medicinal Chemistry
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New 3-amino-2-thioxothiazolidin-4-one-based inhibitors of acetyl- and butyryl-cholinesterase: synthesis and activity
Aim: 2-Thioxothiazolidin-4-one represents a versatile scaffold in drug development. The authors used it to prepare new pot...
Future Medicinal Chemistry
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Mucin glycosylation: a potential target for prostate cancer management
The authors duly acknowledge the Research Grant from DST-SERB, India for supporting this work. P Prasher thanks DST-SERB f...
Future Medicinal Chemistry
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Kynomycin: a beacon of hope in the battle against antibiotic resistance
The authors have no financial involvement with any organization or entity with a financial interest in or financial confli...
Future Medicinal Chemistry
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Synthesis of 1,3,4-oxadiazoles with 4-methoxynaphthalene ring: discovering new compounds with antimicrobial activity
Background: Paracoccidioidomycosis (PCM) is a systemic infection caused by Paracoccidioides spp. (Pb). PCM can be associat...
Future Medicinal Chemistry
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Novel amodiaquine analogues to treat cervical cancer and microbial infection in the future
Aim: To synthesize and explore the therapeutic potential of amodiaquine analogues. Methodology: New promising analogues we...
Future Medicinal Chemistry
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Synthesis, biological evaluation and in silico studies of some new analogues of 3,5-disubstituted thiazolidin-2,4-dione
Background: A new series of 3,5-disubstituted thiazolidin-2,4-dione molecules were derived and characterized using various...
Future Medicinal Chemistry
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Hydrazone–sulfonate hybrids as potential cholinesterase inhibitors: design, synthesis and molecular modeling simulation
Aim: Design and synthesis of a series of hydrazone–sulfonate hybrids, 5a–r. Methodology: The inhibitory properties of the ...
Future Medicinal Chemistry
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