SCI Abstract

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Anti-tumor effects of artemisinin-based oligomers: From monomer to trimer as a novel drug-enhancing strategy
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Synthesis and evaluation of triazole-containing aryl/acyloxy prodrugs of a BTN3A1 ligand
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Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase
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Synthesis and evaluation of novel ebselen derivatives as urease inhibitors for combating Helicobacter pylori infections
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Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations
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Structure-based design, synthesis and biological evaluation of a novel d-amino acid-containing peptide inhibitor by blocking the RAD51-BRCA2 interaction for the treatment of kidney cancer
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Anticancer activity promoted by ligand diversity in diiron thiocarbyne complexes
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Single or double lipid-modified ultra-short antimicrobial peptides for treating infections caused by resistant bacteria
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Structural optimization and characterization of highly potent and selective STAT3 inhibitors for the treatment of triple negative breast cancer
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Discovery of novel thiazole-pleuromutilin derivatives with potent antibacterial activity
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Discovery of naphthoquinone-furo-piperidone derivatives as dual targeting agents of STAT3 and NQO1 for the treatment of breast cancer
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Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway
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Design, synthesis and biological evaluation of dual CDK9/PARP inhibitors for the treatment of cancer
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Advances in the development of phosphodiesterase 5 inhibitors
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Identification of the first-in-class dual inhibitor targeting BAG3 and HSP70 proteins to disrupt multiple chaperone pathways
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From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
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Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma
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Synthesis and evaluation of piceatannol derivatives as novel arginase inhibitors with radical scavenging activity and their potential for collagen reduction in dermal fibroblasts
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Spirocyclic compounds as innovative tools in drug discovery for medicinal chemists
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D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants
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Design, synthesis, and bioactivity investigation of novel cyclic lipopeptide antibiotics targeting top-priority multidrug-resistant gram-negative bacteria
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Synthesis and anti-influenza virus activity of substituted dibenzoxepine-based baloxavir derivatives
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Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders
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Oleanolic acid derivatives against drug-resistant bacteria and fungi by multi-targets to avoid drug resistance
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Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b
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Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4−TLR4∗ homodimerization via AI-powered next-generation screening
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Discovery of CLKs inhibitors for the treatment of non-small cell lung cancer
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New rhodol-sulforaphane conjugates as innovative isothiocyanate-based cytotoxic agents for cancer cells
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Discovery of highly potent triazole derivatives with broad-spectrum antifungal activity based on Iodiconazole
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Covalent inhibitors meet epigenetics: New opportunities
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