Cardiac wasting in patients with cancer

Allan J, Buss LA, Draper N, Currie MJ (2022) Exercise in people with cancer: a spotlight on energy regulation and cachexia. Front Physiol 13:836804. https://doi.org/10.3389/fphys.2022.836804

Article  PubMed  PubMed Central  Google Scholar 

Anker MS, Hadzibegovic S, Lena A, Belenkov Y, Bergler-Klein J, de Boer RA, Farmakis D, von Haehling S, Iakobishvili Z, Maack C, Pudil R, Skouri H, Cohen-Solal A, Tocchetti CG, Coats AJS, Seferović PM, Lyon AR, Heart Failure Association Cardio-Oncology Study Group of the European Society of Cardiology (2019) Recent advances in cardio-oncology: a report from the 'Heart Failure Association 2019 and World Congress on Acute Heart Failure 2019'. ESC Heart Fail 6:1140–1148 https://doi.org/10.1002/ehf2.12551

Anker MS, von Haehling S, Landmesser U, Coats AJS, Anker SD (2018) Cancer and heart failure-more than meets the eye: common risk factors and co-morbidities. Eur J Heart Fail 20:1382–1384. https://doi.org/10.1002/ejhf.1252

Article  PubMed  Google Scholar 

Artaza JN, Reisz-Porszasz S, Dow JS, Kloner RA, Tsao J, Bhasin S, Gonzalez-Cadavid NF (2007) Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. J Endocrinol 194:63–76. https://doi.org/10.1677/JOE-07-0072

Article  CAS  PubMed  Google Scholar 

Barkhudaryan A, Scherbakov N, Springer J, Doehner W (2017) Cardiac muscle wasting in individuals with cancer cachexia. ESC Heart Fail 4:458–467. https://doi.org/10.1002/ehf2.12184

Article  PubMed  PubMed Central  Google Scholar 

de Belchior AC, Angeli JK, Faria Tde O, Siman FD, Silveira EA, Meira EF, da Costa CP, Vassallo DV, Padilha AS (2012) Post-weaning protein malnutrition increases blood pressure and induces endothelial dysfunctions in rats. PLoS ONE 7:e34876. https://doi.org/10.1371/journal.pone.0034876

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bergman JW, Human DG, De Moor MM, Schulz JM (1988) Effect of kwashiorkor on the cardiovascular system. Arch Dis Child 63:1359–1362. https://doi.org/10.1136/adc.63.11.1359

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bordignon C, Dos Santos BS, Rosa DD (2022) Impact of cancer cachexia on cardiac and skeletal muscle: role of exercise training. Cancers (Basel) 14:342. https://doi.org/10.3390/cancers14020342

Article  CAS  PubMed  Google Scholar 

Briet M, Schiffrin EL (2010) Aldosterone: effects on the kidney and cardiovascular system. Nat Rev Nephrol 6:261–273. https://doi.org/10.1038/nrneph.2010.30

Article  CAS  PubMed  Google Scholar 

Cosper PF, Leinwand LA (2011) Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner. Cancer Res 71:1710–1720. https://doi.org/10.1158/0008-5472.CAN-10-3145

Article  CAS  PubMed  Google Scholar 

Coss CC, Clinton SK, Phelps MA (2018) Cachectic cancer patients: immune to checkpoint inhibitor therapy? Clin Cancer Res 24:5787–5789. https://doi.org/10.1158/1078-0432.CCR-18-1847

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cramer L, Hildebrandt B, Kung T, Wichmann K, Springer J, Doehner W, Sandek A, Valentova M, Stojakovic T, Scharnagl H, Riess H, Anker SD, von Haehling S (2014) Cardiovascular function and predictors of exercise capacity in patients with colorectal cancer. J Am Coll Cardiol 64:1310–1319. https://doi.org/10.1016/j.jacc.2014.07.948

Article  PubMed  Google Scholar 

Dostal C, Szabo L, Aioanei C, Abraham D, Zins K, Bakiri L, Wagner E, Podesser BK, Kiss A (2022) Dissecting the progression of cardiac dysfunction in tumor-bearing mice. Cardiovasc Res 118(cvac066):247. https://doi.org/10.1093/cvr/cvac066.247

Article  Google Scholar 

Drott C, Lönnroth C, Lundholm K (1989) Protein synthesis, myosin ATPase activity and myofibrillar protein composition in hearts from tumour-bearing rats and mice. Biochem J 264:191–198. https://doi.org/10.1042/bj2640191

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernandes LG, Tobias GC, Paixão AO, Dourado PM, Voltarelli VA, Brum PC (2020) Exercise training delays cardiac remodeling in a mouse model of cancer cachexia. Life Sci 260:118392. https://doi.org/10.1016/j.lfs.2020.118392

Article  CAS  PubMed  Google Scholar 

Finke D, Heckmann MB, Frey N, Lehmann LH (2021) Cancer—a major cardiac comorbidity with implications on cardiovascular metabolism. Front Physiol 12:729713. https://doi.org/10.3389/fphys.2021.729713

Article  PubMed  PubMed Central  Google Scholar 

Florea VG, Moon J, Pennell DJ, Doehner W, Coats AJ, Anker SD (2004) Wasting of the left ventricle in patients with cardiac cachexia: a cardiovascular magnetic resonance study. Int J Cardiol 97:15–20. https://doi.org/10.1016/j.ijcard.2003.05.050

Article  PubMed  Google Scholar 

Gidh-Jain M, Huang B, Jain P, Gick G, El-Sherif N (1998) Alterations in cardiac gene expression during ventricular remodeling following experimental myocardial infarction. J Mol Cell Cardiol 30:627–637. https://doi.org/10.1006/jmcc.1997.0628

Article  CAS  PubMed  Google Scholar 

Hardee JP, Counts BR, Carson JA (2017) Understanding the role of exercise in cancer cachexia therapy. Am J Lifestyle Med 13:46–60. https://doi.org/10.1177/1559827617725283

Article  PubMed  PubMed Central  Google Scholar 

Hweidi IM, Al-Omari AK, Rababa MJ, Al-Obeisat SM, Hayajneh AA (2021) Cardiac cachexia among patients with chronic heart failure: a systematic review. Nurs Forum 56:916–924. https://doi.org/10.1111/nuf.12623

Article  PubMed  Google Scholar 

Jordan JH, Castellino SM, Meléndez GC, Klepin HD, Ellis LR, Lamar Z, Vasu S, Kitzman DW, Ntim WO, Brubaker PH, Reichek N, D’Agostino RB Jr, Hundley WG (2018) Left ventricular mass change after anthracycline chemotherapy. Circ Heart Fail 11:e004560. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004560

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kadowaki H, Akazawa H, Shindo A, Ueda T, Ishida J, Komuro I (2024) Shared and reciprocal mechanisms between heart failure and cancer—an emerging concept of heart-cancer axis. Circ J 88:182–188. https://doi.org/10.1253/circj.CJ-23-0838

Article  CAS  PubMed  Google Scholar 

Karimian S, Stein J, Bauer B, Teupe C (2016) Impact of severe obesity and weight loss on systolic left ventricular function and morphology: assessment by 2-dimensional speckle-tracking echocardiography. J Obes 2016:2732613. https://doi.org/10.1155/2016/2732613

Article  PubMed  PubMed Central  Google Scholar 

Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer H (2016) Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A 113:10436–10441. https://doi.org/10.1073/pnas.1601650113

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kazemi-Bajestani SMR, Becher H, Butts C, Basappa NS, Smylie M, Joy AA, Sangha R, Gallivan A, Kavsak P, Chu Q, Baracos VE (2019) Rapid atrophy of cardiac left ventricular mass in patients with non-small cell carcinoma of the lung. J Cachexia Sarcopenia Muscle 10:1070–1082. https://doi.org/10.1002/jcsm.12451

Article  PubMed  PubMed Central  Google Scholar 

Kong P, Christia P, Frangogiannis NG (2014) The pathogenesis of cardiac fibrosis. Cell Mol Life Sci 71:549–574. https://doi.org/10.1007/s00018-013-1349-6

Article  CAS  PubMed  Google Scholar 

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28:1-39.e14. https://doi.org/10.1016/j.echo.2014.10.003

Article  PubMed  Google Scholar 

Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, Lancet Physical Activity Series Working Group (2012) Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 380:219–229 https://doi.org/10.1016/S0140-6736

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