The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity

An Y, Duan H (2022) The role of m6A RNA methylation in cancer metabolism. Mol Cancer 21:14. https://doi.org/10.1186/s12943-022-01500-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashrafizaveh S, Ashrafizadeh M, Zarrabi A, Husmandi K, Zabolian A, Shahinozzaman M, Aref AR, Hamblin MR, Nabavi N, Crea F, Wang Y, Ahn KS (2021) Long non-coding RNAs in the doxorubicin resistance of cancer cells. Cancer Lett 508:104–114. https://doi.org/10.1016/j.canlet.2021.03.018

Article  CAS  PubMed  Google Scholar 

Aung LHH, Chen X, Cueva Jumbo JC, Li Z, Wang SY, Zhao C, Liu Z, Wang Y, Li P (2021) Cardiomyocyte mitochondrial dynamic-related lncRNA 1 (CMDL-1) may serve as a potential therapeutic target in doxorubicin cardiotoxicity. Mol Ther Nucleic Acids 25:638–651. https://doi.org/10.1016/j.omtn.2021.08.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Backs J, Olson EN (2006) Control of cardiac growth by histone acetylation/deacetylation. Circ Res 98:15–24. https://doi.org/10.1161/01.RES.0000197782.21444.8f

Article  CAS  PubMed  Google Scholar 

Bertheloot D, Latz E, Franklin BS (2021) Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Cell Mol Immunol 18:1106–1121. https://doi.org/10.1038/s41423-020-00630-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, Bohnsack MT, Jain G, Capece V, Cleve N, Burkhardt S, Hasenfuss G, Fischer A, Toischer K (2020) Changes in m6A RNA methylation contribute to heart failure progression by modulating translation. Eur J Heart Fail 22:54–66. https://doi.org/10.1002/ejhf.1672

Article  CAS  PubMed  Google Scholar 

Boovarahan SR, Kurian GA (2021) Preconditioning the rat heart with 5-azacytidine attenuates myocardial ischemia/reperfusion injury via PI3K/GSK3beta and mitochondrial KATP signaling axis. J Biochem Mol Toxicol 35:e22911. https://doi.org/10.1002/jbt.22911

Article  CAS  PubMed  Google Scholar 

Braile M, Marcella S, Cristinziano L, Galdiero MR, Modestino L, Ferrara AL, Varricchi G, Marone G, Loffredo S (2020) VEGF-A in cardiomyocytes and heart diseases. Int J Mol Sci 21:5294. https://doi.org/10.3390/ijms21155294

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bravo-San Pedro JM, Kroemer G, Galluzzi L (2017) Autophagy and mitophagy in cardiovascular disease. Circ Res 120:1812–1824. https://doi.org/10.1161/circresaha.117.311082

Article  CAS  PubMed  Google Scholar 

Cardinale D, Colombo A, Lamantia G, Colombo N, Civelli M, De Giacomi G, Rubino M, Veglia F, Fiorentini C, Cipolla CM (2010) Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol 55:213–220. https://doi.org/10.1016/j.jacc.2009.03.095

Article  CAS  PubMed  Google Scholar 

Chen L, Yan K-P, Liu X-C, Wang W, Li C, Li M, Qiu C-G (2017) Valsartan regulates TGF-β/Smads and TGF-β/p38 pathways through lncRNA CHRF to improve doxorubicin-induced heart failure. Arch Pharmacal Res 41:101–109. https://doi.org/10.1007/s12272-017-0980-4

Article  CAS  Google Scholar 

Chen S, Wang J, Zhou Y (2019) Long non-coding RNA SNHG1 protects human AC16 cardiomyocytes from doxorubicin toxicity by regulating miR-195/Bcl-2 axis. Biosci Rep 39:BSR20191050. https://doi.org/10.1042/BSR20191050

Article  PubMed  PubMed Central  Google Scholar 

Chen XY, Huang WL, Peng XP, Lv YN, Li JH, Xiong JP (2019) miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway. Toxicol Res (Cambr) 8:875–884. https://doi.org/10.1039/c9tx00100j

Article  CAS  Google Scholar 

Daosukho C, Chen Y, Noel T, Sompol P, Nithipongvanitch R, Velez JM, Oberley TD, Clair DK (2007) Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury. Free Radic Biol Med 42:1818–1825. https://doi.org/10.1016/j.freeradbiomed.2007.03.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christidi E, Brunham LR (2021) Regulated cell death pathways in doxorubicin-induced cardiotoxicity. Cell Death Dis 12:339. https://doi.org/10.1038/s41419-021-03614-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cooper SL, Sandhu H, Hussain A, Mee C, Maddock H (2018) Involvement of mitogen activated kinase kinase 7 intracellular signalling pathway in Sunitinib-induced cardiotoxicity. Toxicology 394:72–83. https://doi.org/10.1016/j.tox.2017.12.005

Article  CAS  PubMed  Google Scholar 

Cui L, Guo J, Zhang Q, Yin J, Li J, Zhou W, Zhang T, Yuan H, Zhao J, Zhang L, Carmichael PL, Peng S (2017) Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity. Toxicol Lett 275:28–38. https://doi.org/10.1016/j.toxlet.2017.04.018

Article  CAS  PubMed  Google Scholar 

Curigliano G, Cardinale D, Dent S, Criscitiello C, Aseyev O, Lenihan D, Cipolla CM (2016) Cardiotoxicity of anticancer treatments: epidemiology, detection, and management. CA Cancer J Clin 66:309–325. https://doi.org/10.3322/caac.21341

Article  PubMed  Google Scholar 

de Baat EC, Mulder RL, Armenian S, Feijen EA, Grotenhuis H, Hudson MM, Mavinkurve-Groothuis AM, Kremer LC, van Dalen EC (2022) Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines. Cochrane Database Syst Rev 9:Cd014638. https://doi.org/10.1002/14651858.CD014638.pub2

Article  PubMed  Google Scholar 

Deng Z, Yao J, Xiao N, Han Y, Wu X, Ci C, Chen K, Geng X (2022) DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis. Lab Investig 102:782–793. https://doi.org/10.1038/s41374-022-00740-8

Article  CAS  PubMed  Google Scholar 

Devaux Y, Nossent AY, CA EU-CCA (2020) A role for m6A RNA methylation in heart failure development? Eur J Heart Fail 22:67–69. https://doi.org/10.1002/ejhf.1714

Article  PubMed  Google Scholar 

Donate Puertas R, Meugnier E, Romestaing C, Rey C, Morel E, Lachuer J, Gadot N, Scridon A, Julien C, Tronc F, Chapuis B, Valla C, Janin A, Pirola L, Mejat A, Rome S, Chevalier P (2017) Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats. Transl Res 184(57–67):e5. https://doi.org/10.1016/j.trsl.2017.03.004

Article  CAS  Google Scholar 

El Kiki SM, Omran MM, Mansour HH, Hasan HF (2020) Metformin and/or low dose radiation reduces cardiotoxicity and apoptosis induced by cyclophosphamide through SIRT-1/SOD and BAX/Bcl-2 pathways in rats. Mol Biol Rep 47:5115–5126. https://doi.org/10.1007/s11033-020-05582-5

Article  CAS  PubMed  Google Scholar 

Elrashidy RA, Hasan RA (2021) Cilostazol preconditioning alleviates cyclophosphamide-induced cardiotoxicity in male rats: mechanistic insights into SIRT1 signaling pathway. Life Sci 266:118822. https://doi.org/10.1016/j.lfs.2020.118822

Article  CAS  PubMed  Google Scholar 

Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861–874. https://doi.org/10.1038/nrg3074

Article  CAS  PubMed  Google Scholar 

Ewer MS, Ewer SM (2010) Cardiotoxicity of anticancer treatments: what the cardiologist needs to know. Nat Rev Cardiol 7:564–575. https://doi.org/10.1038/nrcardio.2010.121

Article  PubMed  Google Scholar 

Ferreira LL, Cervantes M, Froufe HJC, Egas C, Cunha-Oliveira T, Sassone-Corsi P, Oliveira PJ (2020) Doxorubicin persistently rewires cardiac circadian homeostasis in mice. Arch Toxicol 94:257–271. https://doi.org/10.1007/s00204-019-02626-z

Article  CAS  PubMed  Google Scholar 

Ferreira LL, Cunha-Oliveira T, Veloso CD, Costa CF, Wallace KB, Oliveira PJ (2019) Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts. Food Chem Toxicol 124:450–461. https://doi.org/10.1016/j.fct.2018.12.017

Article  CAS  PubMed  Google Scholar 

Gilchrist SC, Barac A, Ades PA, Alfano CM, Franklin BA, Jones LW, La Gerche A, Ligibel JA, Lopez G, Madan K, Oeffinger KC, Salamone J, Scott JM, Squires RW, Thomas RJ, Treat-Jacobson DJ, Wright JS, American Heart Association Exercise CR, Secondary Prevention Committee of the Council on Clinical C, Council on C, Stroke N, Council on Peripheral Vascular D (2019) Cardio-oncology rehabilitation to manage cardiovascular outcomes in cancer patients and survivors: a scientific statement from the American Heart Association. Circulation 139:e997–e1012. https://doi.org/10.1161/CIR.0000000000000679

Article  PubMed  PubMed Central  Google Scholar 

Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J Jr, Chien KR, Ferrara N (2001) A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci USA 98:5780–5785. https://doi.org/10.1073/pnas.091415198

Article  CAS  PubMed  PubMed Central  Google Scholar 

Global Burden of Disease Cancer C, Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, Wolfe C, Hamadeh RR, Moore A, Werdecker A, Gessner BD, Te Ao B, McMahon B, Karimkhani C, Yu C, Cooke GS, Schwebel DC, Carpenter DO, Pereira DM, Nash D, Kazi DS, De Leo D, Plass D, Ukwaja KN, Thurston GD, Yun Jin K, Simard EP, Mills E, Park EK, Catala-Lopez F, deVeber G, Gotay C, Khan G, Hosgood HD 3rd, Santos IS, Leasher JL, Singh J, Leigh J, Jonas JB, Sanabria J, Beardsley J, Jacobsen KH, Takahashi K, Franklin RC, Ronfani L, Montico M, Naldi L, Tonelli M, Geleijnse J, Petzold M, Shrime MG, Younis M, Yonemoto N, Breitborde N, Yip P, Pourmalek F, Lotufo PA, Esteghamati A, Hankey GJ, Ali R, Lunevicius R, Malekzadeh R, Dellavalle R, Weintraub R, Lucas R, Hay R, Rojas-Rueda D, Westerman R, Sepanlou SG, Nolte S, Patten S, Weichenthal S, Abera SF, Fereshtehnejad SM, Shiue I, Driscoll T, Vasankari T, Alsharif U, Rahimi-Movaghar V, Vlassov VV, Marcenes WS, Mekonnen W, Melaku YA, Yano Y, Artaman A, Campos I, MacLachlan J, Mueller U, Kim D, Trillini M, Eshrati B, Williams HC, Shibuya K, Dandona R, Murthy K, Cowie B et al (2015) The global burden of cancer 2013. JAMA Oncol 1:505–527. https://doi.org/10.1001/jamaoncol.2015.0735

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