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Advanced rehabilitation in ischaemic stroke research
Advanced rehabilitation in ischaemic stroke research
For most of the last century, doctors advised less activities and movements after stroke attack. In the 1950s, Twitchell b...
White matter disease derived from vascular and demyelinating origins
White matter disease derived from vascular and demyelinating origins
IntroductionThe white matter of the central nervous system (CNS) is primarily constituted of myelinated axons (tracts) and...
Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical
Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical
IntroductionTo date, stroke remains the second-leading cause of death and the leading cause of disability in much of the w...
Tenecteplase versus alteplase for acute ischaemic stroke: a meta-analysis of phase III randomised trials
Tenecteplase versus alteplase for acute ischaemic stroke: a meta-analysis of phase III randomised trials
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionStroke is the secon...
One-year direct and indirect costs of ischaemic stroke in China
One-year direct and indirect costs of ischaemic stroke in China
IntroductionStroke is one of the leading causes of mortality and disability worldwide,1 and the burden of stroke in China ...
Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke
Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke
IntroductionIschaemic stroke injury disrupts neuronal mitochondrial homeostasis, leading to oxidative stress and subsequen...
Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThe association strengths of current PRSs with risks of stroke and ...
Haemorrhage after thrombectomy with adjuvant thrombolysis in unknown onset stroke depends on high early lesion water uptake
Haemorrhage after thrombectomy with adjuvant thrombolysis in unknown onset stroke depends on high early lesion water uptake
MethodsPatientsThe local high-volume university hospital stroke registry was screened consecutively to select all patients...
Longitudinal associations of cardiovascular health and vascular events with incident dementia
Longitudinal associations of cardiovascular health and vascular events with incident dementia
WHAT IS ALREADY KNOWN ON THIS TOPICCardiovascular health is considered as one of the critical factors in the pathogenesis ...
Residual inflammatory risk predicts long-term outcomes following stenting for symptomatic intracranial atherosclerotic stenosis
Residual inflammatory risk predicts long-term outcomes following stenting for symptomatic intracranial atherosclerotic stenosis
IntroductionIn patients with cerebrovascular diseases, elevated high-sensitivity C-reactive protein (hs-CRP) and low-densi...
Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations
Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations
WHAT IS ALREADY KNOWN ON THIS TOPICSpinal cord cavernous malformations (SCCMs) are rare low-flow vascular malformations wh...
Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage
Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage
IntroductionCortical superficial siderosis (cSS) and cerebral microbleed (CMB) are both haemorrhagic imaging biomarkers of...
Mass effect, aneurysms and flow diverters: Is the pipeline embolization device the Lone Virtuoso? Commentary on 'Pipeline embolization device for intracranial aneurysms presenting with mass effect: a large Chinese cohort by Zhao et al
Mass effect, aneurysms and flow diverters: Is the pipeline embolization device the Lone Virtuoso? Commentary on 'Pipeline embolization device for intracranial aneurysms presenting with mass effect: a large Chinese cohort by Zhao et al
In the treatment of symptomatic intracranial aneurysms, the study by Zhao et al stands as a notable addition to the growin...
Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage
Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage
IntroductionThe pathophysiology of spontaneous intracerebral haemorrhage (ICH) reflects injury to small cerebral blood ves...
Stroke depression: a concept with clinical applicability
Stroke depression: a concept with clinical applicability
Epidemiology of strokeStroke is the second-leading cause of death in the world, accounting for 11.8% of all deaths. It is ...
Neglected Mendelian causes of stroke in adult Chinese patients who had an ischaemic stroke or transient ischaemic attack
Neglected Mendelian causes of stroke in adult Chinese patients who had an ischaemic stroke or transient ischaemic attack
MethodsStudy population and classification of Mendelian causes of strokeThe CNSR-III is a nationwide prospective registry ...
A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm
A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm
IntroductionIntracranial aneurysm (IA) is a major public health burden that affects 3.2%–7.0% of the adult population.1 Su...
Model based on single-nucleotide polymorphism to discriminate aspirin resistance patients
Model based on single-nucleotide polymorphism to discriminate aspirin resistance patients
IntroductionAspirin is widely used for preventing ischaemic cerebrovascular and cardiovascular diseases,1 2 as well as isc...
Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation: a multi-institutional, retrospective study
Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation: a multi-institutional, retrospective study
IntroductionThe prevalence of cerebral cavernous malformations (CCMs) is estimated between 0.2% and 0.5%.1 Twenty-five per...
Efficacy and safety of a neurointerventional operation robotic assistance system in cerebral angiography
Efficacy and safety of a neurointerventional operation robotic assistance system in cerebral angiography
WHAT IS ALREADY KNOWN ON THIS TOPICAt present, neurointerventional surgery requires angiographers to perform operations in...
APE1 regulates mitochondrial DNA damage repair after experimental subarachnoid haemorrhage in vivo and in vitro
APE1 regulates mitochondrial DNA damage repair after experimental subarachnoid haemorrhage in vivo and in vitro
IntroductionSubarachnoid haemorrhage (SAH) is a type of haemorrhagic stroke caused by intracerebral aneurysm rupture, resu...
COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke (COTTIS): a pilot study
COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke (COTTIS): a pilot study
IntroductionAlthough endovascular treatment (EVT) is known to be beneficial in acute ischaemic stroke patients with large ...
Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry)
Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry)
The CMC Vellore CVT registry is the largest single-centre CVT cohort reported in the literature. This study assessed the c...
Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?
Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?
WHAT IS ALREADY KNOWN ON THIS TOPICEmergent intraprocedural stenting of extracranial or intracranial arteries is often nec...
Individualised evaluation based on pathophysiology for moyamoya vasculopathy: application in surgical revascularisation
Individualised evaluation based on pathophysiology for moyamoya vasculopathy: application in surgical revascularisation
WHAT IS ALREADY KNOWN ON THIS TOPICAlthough the long-term effects of bypass surgery for moyamoya vasculopathy have been co...
Retinal artery/arteriole occlusion risks after endovascular treatment for unruptured intracranial aneurysm
Retinal artery/arteriole occlusion risks after endovascular treatment for unruptured intracranial aneurysm
IntroductionRetinal artery/arteriole occlusion (RAO) is a major cause of sudden painless vision loss that often results in...
Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients: insight from the ANGEL-ACT registry
Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients: insight from the ANGEL-ACT registry
WHAT IS ALREADY KNOWN ON THIS TOPICThere is little literature about futile recanalisation after endovascular therapy (EVT)...
Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study
Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study
Introduction and rationaleOver the last decade, intravenous thrombolytic therapy has been the cornerstone treatment for pa...
Bilateral effect of acupuncture on cerebrum and cerebellum in ischaemic stroke patients with hemiparesis: a randomised clinical and neuroimaging trial
Bilateral effect of acupuncture on cerebrum and cerebellum in ischaemic stroke patients with hemiparesis: a randomised clinical and neuroimaging trial
IntroductionAge-standard stroke has ranked as the leading cause of death and disability-adjusted life-years in China’s per...
Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update
Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update
HighlightsThe clinical management of ischaemic cerebrovascular diseases comprises a total of 287 recommendations, includin...
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