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Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly
Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly
Cognitive decline with age has heterogeneous, which might be related to the accumulation of protective factors called cogn...
Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia
Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia
The increasing prevalence of dementia and the introduction of disease-modifying therapies (DMTs) highlight the need for ef...
Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort
Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort
Second-generation tau tracers for positron emission tomography (PET) show high affinity for paired helical filaments tau d...
Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway
Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway
Neurodegenerative disorders, including Alzheimer’s disease (AD), have been linked to alterations in tryptophan (TRP)...
Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy – a cross-sectional study
Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy – a cross-sectional study
While several studies in cerebral amyloid angiopathy (CAA) focus on cognitive function, data on neuropsychiatric symptoms ...
Reliability of the assessment of the clinical dementia rating scale from the analysis of medical records in comparison with the reference method
Reliability of the assessment of the clinical dementia rating scale from the analysis of medical records in comparison with the reference method
The Clinical Dementia Rating (CDR) scale allows to detect the presence of dementia and to assess its severity, however its...
A novel PDHK inhibitor restored cognitive dysfunction and limited neurodegeneration without affecting amyloid pathology in 5xFAD mouse, a model of Alzheimer’s disease
A novel PDHK inhibitor restored cognitive dysfunction and limited neurodegeneration without affecting amyloid pathology in 5xFAD mouse, a model of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia. Although drugs focusing on reducing amyloid β slo...
CSF neurogranin levels as a biomarker in Alzheimer’s disease and frontotemporal lobar degeneration: a cross-sectional analysis
CSF neurogranin levels as a biomarker in Alzheimer’s disease and frontotemporal lobar degeneration: a cross-sectional analysis
There is initial evidence suggesting that biomarker neurogranin (Ng) may distinguish Alzheimer’s disease (AD) from o...
Updated safety results from phase 3 lecanemab study in early Alzheimer’s disease
Updated safety results from phase 3 lecanemab study in early Alzheimer’s disease
Alzheimer disease (AD) is a major health problem of aging, with tremendous burden on healthcare systems, patients, and fam...
Association between untreated and treated blood pressure levels and cognitive decline in community-dwelling middle-aged and older adults in China: a longitudinal study
Association between untreated and treated blood pressure levels and cognitive decline in community-dwelling middle-aged and older adults in China: a longitudinal study
Optimal blood pressure (BP) levels to reduce the long-term risk of cognitive decline remains controversial. We aimed to in...
Cerebrospinal fluid α-synuclein adds the risk of cognitive decline and is associated with tau pathology among non-demented older adults
Cerebrospinal fluid α-synuclein adds the risk of cognitive decline and is associated with tau pathology among non-demented older adults
The role of α-synuclein in dementia has been recognized, yet its exact influence on cognitive decline in non-demented...
Plasma biomarkers increase diagnostic confidence in patients with Alzheimer’s disease or frontotemporal lobar degeneration
Plasma biomarkers increase diagnostic confidence in patients with Alzheimer’s disease or frontotemporal lobar degeneration
The recent development of techniques to assess plasma biomarkers has changed the way the research community envisions the ...
Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank
Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank
Previous studies on the associations between serum urate levels and neurodegenerative outcomes have yielded inconclusive r...
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Alzheimer’s disease is a neurodegenerative condition associated with the accumulation of two misfolded proteins, amy...
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
Identifying individuals with mild cognitive impairment (MCI) who are likely to progress to Alzheimer’s disease and r...
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impair...
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
To estimate the perceived value of additional testing with amyloid-PET in Euros in healthy participants acting as analogue...
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. Howev...
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Participant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a funct...
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Cognitive complaints are often regarded as an early sign of Alzheimer’s disease (AD) but may also occur in several o...
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
There are increasing reports on the cognitive and emotional benefits of positive reminiscence therapy in older people. The...
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
Identification of patients with idiopathic normal pressure hydrocephalus (iNPH) in a collective with suspected neurodegene...
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumula...
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Health-related quality of life (HR-QoL) is an important outcome for patients and crucial for demonstrating the value of ne...
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
The Alzheimer’s disease (AD) risk gene ABCA7 has suggested functions in lipid metabolism and the immune system. Rare...
Distinct effects of cholesterol profile components on amyloid and vascular burdens
Distinct effects of cholesterol profile components on amyloid and vascular burdens
Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships o...
A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults
A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults
Genomic study of cognition decline while considering baseline cognition and lifestyle behaviors is scarce. We aimed to eva...
Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study
Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study
Subjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer’s disease in memory clini...
Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI
Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI
Understanding the pathological characteristics of various mild cognitive impairment (MCI) subtypes is crucial for the diff...
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up ...
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