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Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth
Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth
Colorectal cancer (CRC) is characterized by an immunosuppressive and inflammatory microenvironment, thus responds poorly t...
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis
Glucose metabolism disorder is an important hallmark of rheumatoid arthritis (RA). Inhibiting key glycolysis enzymes is th...
Kv1.3 knockdown attenuates alcohol-related liver injury in mice through induction of tryptamine
Kv1.3 knockdown attenuates alcohol-related liver injury in mice through induction of tryptamine
Alcohol-related liver disease (ALD) refers to a spectrum of liver diseases caused by chronic or acute excessive alcohol co...
An endoplasmic reticulum-targeting photodynamic AMPK agonist activates breast cancer immunotherapy through promoting immunogenic cell death and downregulation of PD-L1
An endoplasmic reticulum-targeting photodynamic AMPK agonist activates breast cancer immunotherapy through promoting immunogenic cell death and downregulation of PD-L1
Most aggressive malignancies exhibit low immunogenicity, exacerbated by tumor immune evasion mechanisms that undermine imm...
The conformational epitope of a gp41-specific mucosal protective IgA binds to the HIV-1 envelope and neutralizes infection
The conformational epitope of a gp41-specific mucosal protective IgA binds to the HIV-1 envelope and neutralizes infection
HIV-1 envelope conformational changes necessary for viral infection make the gp41 subunit a key target for antiviral drugs...
NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway
NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway
Ischemic stroke is one of the most common forms of stroke. There are no effective pharmacological agents to promote recove...
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors
GluN3A-containing NMDA receptors have recently emerged as promising therapeutic targets for neurological disorders. Howeve...
Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer
Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer
The adverse events associated with antitumour drugs have recently emerged as an increasingly significant clinical concern....
Branched-chain amino acids promote hepatic Cyp7a1 expression and bile acid synthesis via suppressing FGF21-ERK pathway
Branched-chain amino acids promote hepatic Cyp7a1 expression and bile acid synthesis via suppressing FGF21-ERK pathway
Branched-chain amino acids (BCAAs) including leucine, isoleucine and valine have been linked with metabolic and cardiovasc...
Editorial Expression of Concern: The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells
Authors and AffiliationsResearch Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditi...
SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1)
SP600125, a selective JNK inhibitor, is a potent inhibitor of NAD(P)H: quinone oxidoreductase 1 (NQO1)
The c-Jun N-terminal kinases (JNKs) has been identified as a critical modulator in multiple cellular processes, including ...
Endothelial FOSL1 drives angiotensin II-induced myocardial injury via AT1R-upregulated MYH9
Endothelial FOSL1 drives angiotensin II-induced myocardial injury via AT1R-upregulated MYH9
Vascular remodeling represents a pathological basis for myocardial pathologies, including myocardial hypertrophy and myoca...
Acid-sensing ion channel 1a promotes alcohol-associated liver disease in mice via regulating endoplasmic reticulum autophagy
Acid-sensing ion channel 1a promotes alcohol-associated liver disease in mice via regulating endoplasmic reticulum autophagy
Alcohol-associated liver disease (ALD) is a hepatocyte dysfunction disease caused by chronic or excessive alcohol consumpt...
Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson’s disease
Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson’s disease
The locus coeruleus norepinephrine (LC-NE) system plays an important role in regulating brain function, and its neuronal l...
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy
Tumor cells are characterized by rapid proliferation. In order to provide purines for DNA and RNA synthesis, inosine 5R...
The novel BCL-2/BCL-XL inhibitor APG-1252-mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer
The novel BCL-2/BCL-XL inhibitor APG-1252-mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer
HER2-positive gastric cancer has a poor prognosis, with a high incidence of drug resistance and a lack of effective treatm...
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A
Pulmonary fibrosis (PF) is a chronic, progressive and irreversible interstitial lung disease characterized by unremitting ...
Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway
Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway
Abdominal aortic aneurysm (AAA) is a degenerative disease that caused mortality in people aged >65. Senescence play...
BNIP3-mediated mitophagy attenuates hypoxic–ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62–KEAP1–NRF2 pathway activation to maintain iron and redox homeostasis
BNIP3-mediated mitophagy attenuates hypoxic–ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62–KEAP1–NRF2 pathway activation to maintain iron and redox homeostasis
As a major contributor to neonatal death and neurological sequelae, hypoxic-ischemic encephalopathy (HIE) lacks a viable m...
Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma
Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma
Chromosome instability (CIN) and subsequent aneuploidy are prevalent in various human malignancies, influencing tumor prog...
LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10
LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10
While immune checkpoint inhibitors (ICIs) are promising in the treatment of metastatic melanoma, about half of patients do...
Author Correction: Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells
Author Correction: Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells
a The FKB04 chemical structure. b Liver cancer cells and liver normal cell lines were pretreated with FKB04 for 2 days, an...
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer
The transcription factor STAT3 is a promising target for the treatment of non-small cell lung cancer (NSCLC). STAT3 activi...
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates
Positron emission tomography (PET) targeting translocator protein 18 kDa (TSPO) can be used for the noninvasive dete...
Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway
Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience...
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 2012...
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
Epilepsy is a chronic and debilitating neurological disorder, known for the occurrence of spontaneous and recurrent seizur...
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis
Colorectal cancer (CRC) is a prevalent form of gastrointestinal malignancy with challenges in chemotherapy resistance and ...
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging...
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer
The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for ...
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