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Current status and trend of global research on the pharmacological effects of emodin family: bibliometric study and visual analysis
Current status and trend of global research on the pharmacological effects of emodin family: bibliometric study and visual analysis
Emodin, as a natural active ingredient, has shown great application potential in the fields of medicine, food and cosmetic...
Coptisine inhibits esophageal carcinoma growth by modulating pyroptosis via inhibition of HGF/c-Met signaling
Coptisine inhibits esophageal carcinoma growth by modulating pyroptosis via inhibition of HGF/c-Met signaling
Esophageal carcinoma is a highly prevalent malignancy worldwide. The present study aimed to investigate the mechanism by w...
Comparative effects of dexpanthenol and thymoquinone on colistin-induced neurotoxicity in rats
Comparative effects of dexpanthenol and thymoquinone on colistin-induced neurotoxicity in rats
Colistin is used as a last-line treatment for multidrug-resistant gram-negative bacilli. Neurotoxicity limits clinic use o...
Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis
Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis
The progression of periodontal disease (PD) involves the action of oxidative stress mediators. Antioxidant agents may pote...
Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential
Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential
Neuropathic pain, a challenging condition often associated with diabetes, trauma, or chemotherapy, impairs patients’...
Tocilizumab alleviated lipopolysaccharide-induced acute lung injury by improving PI3K/AKT pathway
Tocilizumab alleviated lipopolysaccharide-induced acute lung injury by improving PI3K/AKT pathway
Acute lung injury (ALI) is a severe inflammatory condition of the respiratory system, associated with high morbidity and m...
Sexual dysfunctions associated with antipsychotic drug intake: a retrospective analysis of the FDA adverse events reporting system (FAERS)
Sexual dysfunctions associated with antipsychotic drug intake: a retrospective analysis of the FDA adverse events reporting system (FAERS)
Sexual dysfunctions (SD) are common and debilitating side effects of antipsychotics. The current study analyzes the occurr...
Exploring the impact of cuproptosis-related genes on immune infiltration in rheumatoid arthritis
Exploring the impact of cuproptosis-related genes on immune infiltration in rheumatoid arthritis
Immune infiltration plays a significant role in the pathogenesis of rheumatoid arthritis (RA). Cuproptosis, a newly charac...
MiRNAs: main players of cancer drug resistance target ABC transporters
MiRNAs: main players of cancer drug resistance target ABC transporters
Chemotherapy remains the cornerstone of cancer treatment; however, its efficacy is frequently compromised by the developme...
Morin, as a natural flavonoid, provides promising influences against cardiovascular diseases
Morin, as a natural flavonoid, provides promising influences against cardiovascular diseases
The present investigation evaluated the potential impacts of morin, a natural flavonoid, against cardiovascular disorders....
MircoRNAs predict and modulate responses to chemotherapy in leukemic patients
MircoRNAs predict and modulate responses to chemotherapy in leukemic patients
Leukemia covers a broad category of cancer malignancies that specifically affect bone marrow and blood cells. While differ...
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1
To investigate the effect of icariin (ICA) on hepatocellular carcinoma (HCC) and its autophagy/apoptosis mechanism in HCC....
Neurotensin receptor agonist PD149163 modulates LPS-induced enterocyte apoptosis by downregulating TNFR pathway and executioner caspase 3 in endotoxemic mice: insights from in vivo and in silico study
Neurotensin receptor agonist PD149163 modulates LPS-induced enterocyte apoptosis by downregulating TNFR pathway and executioner caspase 3 in endotoxemic mice: insights from in vivo and in silico study
This study was designed to evaluate the dose-dependent efficacy of neurotensin receptor-1 (NTSR1) agonist PD149163 in the ...
An update on selective estrogen receptor modulator: repurposing and formulations
An update on selective estrogen receptor modulator: repurposing and formulations
The selective estrogen receptor modulator (SERM) raloxifene hydrochloride (RLH) is used extensively in the management and ...
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy
One of the most common tumors is hepatocellular carcinoma (HCC), and the prognosis for late-stage HCC is still not good. I...
Doxorubicin treatment has a biphasic effect over time on dopamine release and impulsive behavior in Wistar rats
Doxorubicin treatment has a biphasic effect over time on dopamine release and impulsive behavior in Wistar rats
Doxorubicin (Dox) is a chemotherapy agent commonly used to treat multiple types of cancers and is associated with cognitiv...
Network pharmacology-based strategy to reveal the mechanism of pinocembrin against ovarian cancer
Network pharmacology-based strategy to reveal the mechanism of pinocembrin against ovarian cancer
Ovarian cancer stands as the foremost cause of mortality among gynaecological diseases globally, characterized by high mor...
Immune cell traits and causal relationships with cholecystitis: a mendelian randomization analysis
Immune cell traits and causal relationships with cholecystitis: a mendelian randomization analysis
Cholecystitis, characterized by inflammation of the gallbladder, is intricately linked to immune cells and the cytokines t...
An updated landscape on nanopharmaceutical delivery for mitigation of colon cancer
An updated landscape on nanopharmaceutical delivery for mitigation of colon cancer
Globally, colorectal cancer (CRC) continues to rank among the leading causes of cancer-related death. Systemic toxicity, m...
A systematic review of the traditional uses, chemistry, and curative aptitude of echinacoside—a phenylethanoid glycoside
A systematic review of the traditional uses, chemistry, and curative aptitude of echinacoside—a phenylethanoid glycoside
Echinacoside (ECH), a naturally occurring water-soluble phenylethanoid glycoside, is one of the primary bioactive compound...
Self-nanoemulsifying drug delivery system for nebulization: fabrication and evaluation for systemic delivery of atorvastatin
Self-nanoemulsifying drug delivery system for nebulization: fabrication and evaluation for systemic delivery of atorvastatin
The study undertakes the development of an atorvastatin-loaded self-nanoemulsifying drug delivery system (SNEDDS) to impro...
The molecular mechanism of berberine affecting psoriasis skin inflammation by regulating keratinocyte pyroptosis via the p38 MAPK/NF-κB pathway
The molecular mechanism of berberine affecting psoriasis skin inflammation by regulating keratinocyte pyroptosis via the p38 MAPK/NF-κB pathway
Berberine (BBR), a Rhizoma Coptis-sourced isoquinoline alkaloid, is an effective drug for psoriasis treatment with its the...
VSIG-3/IGSF11 silencing in A2058 melanoma cells simultaneously suppresses melanoma progression and induces anti-tumoral cytokine profile in human T cells: In silico and in vitro study
VSIG-3/IGSF11 silencing in A2058 melanoma cells simultaneously suppresses melanoma progression and induces anti-tumoral cytokine profile in human T cells: In silico and in vitro study
VISTA is a newly discovered immune checkpoint whose functional mechanisms have become increasingly important to study due ...
Protective effect of aspirin and gentisic acid, a plant-derived phenolic acid, on acrylamide-induced neurotoxicity by inhibiting apoptosis and autophagy
Protective effect of aspirin and gentisic acid, a plant-derived phenolic acid, on acrylamide-induced neurotoxicity by inhibiting apoptosis and autophagy
Acrylamide (ACR) is a toxic agent for humans and animals. Gentisic acid, an aspirin metabolite, has anti...
Oral toxicity assessment and the mitigation of lung carcinogenesis by phytol and α-bisabolol combination treatment in swiss albino mice: insights into redox enzyme modulation and caspase-dependent cell death mechanisms
Oral toxicity assessment and the mitigation of lung carcinogenesis by phytol and α-bisabolol combination treatment in swiss albino mice: insights into redox enzyme modulation and caspase-dependent cell death mechanisms
This study examined the safety and potential anti-lung cancer effects of combinations of phytol and α-bisabolol in Sw...
Pre-clinical study of IR808 dye for cervical cancer in vitro and in vivo imaging
Pre-clinical study of IR808 dye for cervical cancer in vitro and in vivo imaging
There is an urgent need for improved methods for early screening and rapid diagnosis of cervical cancer since current conv...
Cancer-associated fibroblast-secreted exosomal miR-454-3p inhibits lipid metabolism and ferroptosis in breast cancer by targeting ACSL4
Cancer-associated fibroblast-secreted exosomal miR-454-3p inhibits lipid metabolism and ferroptosis in breast cancer by targeting ACSL4
Cancer-associated fibroblasts (CAFs) participate in the development of the tumor microenvironment through the secretion of...
A single-dose, randomized, crossover bioequivalence study of levamlodipine besilate tablets in healthy subjects
A single-dose, randomized, crossover bioequivalence study of levamlodipine besilate tablets in healthy subjects
Levamlodipine, the levorotatory form of amlodipine racemate, has a blood pressure–lowering effect that is twice that...
Individual and combined antagonism of aryl hydrocarbon receptor (AhR) and estrogen receptors (ERs) offers distinct level of protection against Bisphenol A (BPA)-induced pancreatic islet cell toxicity in mice
Individual and combined antagonism of aryl hydrocarbon receptor (AhR) and estrogen receptors (ERs) offers distinct level of protection against Bisphenol A (BPA)-induced pancreatic islet cell toxicity in mice
Bisphenol A (BPA), a pervasive endocrine-disrupting chemical, is known to convey harmful impact on pancreatic islets throu...
Advancing against drug-resistant tuberculosis: an extensive review, novel strategies and patent landscape
Advancing against drug-resistant tuberculosis: an extensive review, novel strategies and patent landscape
Drug-resistant tuberculosis (DR-TB) represents a pressing global health issue, leading to heightened morbidity and mortali...
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