Altabbal S, Athamnah K, Rahma A et al (2023) Propolis: a detailed insight of its anticancer molecular mechanisms. Pharmaceuticals 16:450. https://doi.org/10.3390/ph16030450

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashrafi A, Akter Z, Modareszadeh P et al (2022) Current landscape of therapeutic resistance in lung cancer and promising strategies to overcome resistance. Cancers (Basel) 14:4562. https://doi.org/10.3390/cancers14194562

Article  CAS  PubMed  Google Scholar 

Asokkumar K, UmaMaheswari M, Sivashanmugam AT et al (2009) Free radical scavenging and antioxidant activities of Glinus oppositifolius (carpet weed) using different in vitro assay systems. Pharm Biol 47:474–482. https://doi.org/10.1080/13880200902817901

Article  CAS  Google Scholar 

Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT (2021) Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov 20:200–216. https://doi.org/10.1038/s41573-020-00114-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boice A, Bouchier-Hayes L (2020) Targeting apoptotic caspases in cancer. Biochim Biophys Acta - Mol Cell Res 1867:118688. https://doi.org/10.1016/j.bbamcr.2020.118688

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonifacio M, Rigo A, Guardalben E et al (2012) α-bisabolol is an effective proapoptotic agent against BCR-ABL+ cells in synergism with imatinib and nilotinib. PLoS ONE 7:e46674. https://doi.org/10.1371/journal.pone.0046674

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castilhos RV, Grützmacher AD, Coats JR (2018) Acute toxicity and sublethal effects of terpenoids and essential oils on the predator Chrysoperla externa (Neuroptera: Chrysopidae). Neotrop Entomol 47:311–317. https://doi.org/10.1007/s13744-017-0547-6

Article  CAS  PubMed  Google Scholar 

Cavalieri E, Mariotto S, Fabrizi C et al (2004) α-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun 315:589–594. https://doi.org/10.1016/j.bbrc.2004.01.088

Article  CAS  PubMed  Google Scholar 

Chen W, Hou J, Yin Y et al (2010) α-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFκB. Biochem Pharmacol 80:247–254. https://doi.org/10.1016/j.bcp.2010.03.021

Article  CAS  PubMed  Google Scholar 

Cottart C-H, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux J-L (2010) Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res 54:7–16. https://doi.org/10.1002/mnfr.200900437

Article  CAS  PubMed  Google Scholar 

De La Chapa JJ, Singha PK, Lee DR, Gonzales CB (2018) Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis. J Oral Pathol Med 47:674–682. https://doi.org/10.1111/jop.12735

Article  CAS  PubMed  Google Scholar 

DeVita VT, Chu E (2008) A history of cancer chemotherapy. Cancer Res 68:8643–8653. https://doi.org/10.1158/0008-5472.CAN-07-6611

Article  CAS  PubMed  Google Scholar 

Dicson SM, Samuthirapandi M, Govindaraju A, Kasi PD (2015) Evaluation of in vitro and in vivo safety profile of the Indian traditional medicinal plant Grewia tiliaefolia. Regul Toxicol Pharmacol 73:241–247. https://doi.org/10.1016/j.yrtph.2015.07.011

Article  PubMed  Google Scholar 

Didier AJ, Stiene J, Fang L et al (2023) Antioxidant and anti-tumor effects of dietary vitamins A, C, and E. Antioxidants 12:632. https://doi.org/10.3390/antiox12030632

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dzobo K (2022) The role of natural products as sources of therapeutic agents for innovative drug discovery. In: Compr Pharmacol Elsevier, pp 408–422

Fan T-J, Han L-H, Cong R-S, Liang J (2005) Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai) 37:719–727. https://doi.org/10.1111/j.1745-7270.2005.00108.x

Article  CAS  PubMed  Google Scholar 

Furumoto T, Wang R, Okazaki K et al (2002) Antitumor promoters in leaves of jute (Corchorus capsularis and Corchorus olitorius). Food Sci Technol Res 8:239–243. https://doi.org/10.3136/fstr.8.239

Article  CAS  Google Scholar 

Hecht SS (1999) Tobacco smoke carcinogens and lung cancer. JNCI J Natl Cancer Inst 91:1194–1210. https://doi.org/10.1093/jnci/91.14.1194

Article  CAS  PubMed  Google Scholar 

Jan R, Chaudhry G-S (2019) Understanding apoptosis and apoptotic pathways targeted cancer therapeutics. Adv Pharm Bull 9:205–218. https://doi.org/10.15171/apb.2019.024

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kamatou GPP, Viljoen AM (2010) A review of the application and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. J Am Oil Chem Soc 87:1–7. https://doi.org/10.1007/s11746-009-1483-3

Article  CAS  Google Scholar 

Kim J (1998) Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis 19:1847–1853. https://doi.org/10.1093/carcin/19.10.1847

Article  CAS  PubMed  Google Scholar 

Kiruthiga C, Jaya Balan D, Jafni S et al (2024a) Phytol and (−)-α-bisabolol synergistically trigger intrinsic apoptosis through redox and Ca2+ imbalance in non-small cell lung cancer. Biocatal Agric Biotechnol 56:103005. https://doi.org/10.1016/j.bcab.2023.103005

Article  CAS  Google Scholar 

Kiruthiga C, Niharika K, Devi KP (2024b) Phytol and α-bisabolol synergy induces autophagy and apoptosis in A549 cells and additional molecular insights through comprehensive proteome analysis via nano LC-MS/MS. Anticancer Agents Med Chem 24:773–788. https://doi.org/10.2174/0118715206289038240214102951

Article  CAS  PubMed  Google Scholar 

Kiruthiga C, Jaya D, Nagaiah B, Prasath H (2024c). Synergistic Induction of Apoptosis in Lung Cancer Cells through Co-Delivery of PLGA Phytol/α-Bisabolol Nanoparticles. https://doi.org/10.1007/s00210-023-02935-2

Article  Google Scholar 

Liu X, Chen Z (2017) The pathophysiological role of mitochondrial oxidative stress in lung diseases. J Transl Med 15:207. https://doi.org/10.1186/s12967-017-1306-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

McIlwain DR, Berger T, Mak TW (2013) Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol 5:1–28. https://doi.org/10.1101/cshperspect.a008656

Article  CAS  Google Scholar 

MeeranNagoor MF, Javed H, Al TH et al (2017) Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development. Front Pharmacol 8:1–34. https://doi.org/10.3389/fphar.2017.00380

Article  CAS  Google Scholar 

Mokhtari RB, Homayouni TS, Baluch N et al (2017) Combination therapy in combating cancer. Oncotarget 8:38022–38043. https://doi.org/10.18632/oncotarget.16723

Article  PubMed Central  Google Scholar 

Moorthy B, Chu C, Carlin DJ (2015) Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. Toxicol Sci 145:5–15. https://doi.org/10.1093/toxsci/kfv040

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mousa AM, El-Sammad NM, Abdel-Halim AH et al (2019) Lagerstroemia speciosa (L.) pers leaf extract attenuates lung tumorigenesis via alleviating oxidative stress, inflammation and apoptosis. Biomolecules 9:871. https://doi.org/10.3390/biom9120871

Article  CAS