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A liver-directed route to reverse allergies
Discover the world’s best science and medicine | Nature.com
Hinge modifier approach opens door to drugging HECT E3 ligases
Hinge modifier approach opens door to drugging HECT E3 ligases
Discover the world’s best science and medicine | Nature.com
The race to reset autoimmune diseases
The race to reset autoimmune diseases
Discover the world’s best science and medicine | Nature.com
FDA approves a rare novel–novel oncology combination that pairs a first-in-class FAK inhibitor with a MEK–RAF glue inhibitor
FDA approves a rare novel–novel oncology combination that pairs a first-in-class FAK inhibitor with a MEK–RAF glue inhibitor
Discover the world’s best science and medicine | Nature.com
Targeting neutrophils for cancer therapy
Targeting neutrophils for cancer therapy
Neutrophils are among the most abundant immune cell types in the tumour microenvironment and have been associated with poo...
Is the FDA’s plan to phase out animal toxicity testing realistic?
Is the FDA’s plan to phase out animal toxicity testing realistic?
Lorna Ewart, Chief Scientific Officer at Emulate, discusses the new opportunities and remaining challenges facing organs o...
Amylin takes another shot at the obesity prize
Amylin takes another shot at the obesity prize
Drug developers are re-advancing amylin analogues for obesity, two decades since the FDA approved the first of these hormo...
Innovative Medicines Initiative public–private partnerships to enhance translational safety
Innovative Medicines Initiative projects focused on translational safety have developed a range of tools to improve precli...
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap
In recent years, a small number of people with rare diseases caused by unique genetic variants have been treated with ther...
Antimalarial drug hits cardiac fibrosis
Antimalarial drug hits cardiac fibrosis
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Lundbeck pays US$2.6 billion for Longboard and its lead epilepsy drug
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JAK inhibition combats adverse skin reaction
JAK inhibition combats adverse skin reaction
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Benchmarking recruitment rates for phase III trials
Benchmarking recruitment rates for phase III trials
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DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications
DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications
The DNA damage response (DDR) is a network of proteins that coordinate DNA repair and cell-cycle checkpoints to prevent da...
FDA approves l-amino acid decarboxylase deficiency gene therapy
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Senescence as a therapeutic target in cancer and age-related diseases
Senescence as a therapeutic target in cancer and age-related diseases
Cellular senescence is a stress response that restrains the growth of aged, damaged or abnormal cells. Thus, senescence ha...
Chinese innovative drug R&D trends in 2024
Chinese innovative drug R&D trends in 2024
Discover the world’s best science and medicine | Nature.com
Comprehensive measurement of biopharmaceutical R&D investment
Comprehensive measurement of biopharmaceutical R&D investment
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The breast cancer drug market
The breast cancer drug market
Discover the world’s best science and medicine | Nature.com
A golden age of muscarinic acetylcholine receptor modulation in neurological diseases
A golden age of muscarinic acetylcholine receptor modulation in neurological diseases
Over the past 40 years, the muscarinic acetylcholine receptor family, particularly the M1-receptor and M4-receptor subtype...
FDA approves first complement factor D inhibitor
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Small molecule improves muscle function in myasthenia gravis
Small molecule improves muscle function in myasthenia gravis
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FDA approves an HDAC inhibitor for Duchenne muscular dystrophy
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FDA new drug approvals in Q1 2024
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Targeting immunogenic cell stress and death for cancer therapy
Targeting immunogenic cell stress and death for cancer therapy
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific stressors, occupies a centra...
The antibody–drug conjugate landscape
The antibody–drug conjugate landscape
Discover the world’s best science and medicine | Nature.com
Three-step cures for autoimmune diseases?
Three-step cures for autoimmune diseases?
Robert Plenge, head of Research at Bristol Myers Squibb, discusses his vision of sequential immunotherapy for autoimmune d...
RNA-editing drugs advance into clinical trials
RNA-editing drugs advance into clinical trials
ADAR-based editors that can change the mRNA code offer new opportunities in both rare genetic diseases and common complex ...
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is wide...
Extracellular targeted protein degradation: an emerging modality for drug discovery
Extracellular targeted protein degradation: an emerging modality for drug discovery
Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular pro...
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