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Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Children treated in a pediatric intensive care unit (PICU) often receive several drugs together, among them drugs defined ...
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Congenital heart disease (CHD) is one of the leading causes of death. Safe and timely medical interventions, especially in...
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis
The efficacy and safety of propranolol for retinopathy of prematurity (ROP) remain under debate. This network meta-analysi...
Paediatric Drug Development in China: Current Status and Future Prospects
Paediatric Drug Development in China: Current Status and Future Prospects
For more than two decades, regulatory agencies throughout the world released guidelines, rules and laws to stimulate and a...
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review
Immunosuppressive medications play a crucial role in determining both organ and patient survival following liver transplan...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells...
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
Antiseizure medications (ASMs) can potentially trigger psychobehavioral adverse events associated with the onset or exacer...
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Vamorolone has recently been approved for the management of Duchenne muscular dystrophy to replace glucocorticosteroids, w...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
This narrative review examines the evolving role of opioids in managing procedural and surgical pain in pediatric oncology...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure ...
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematological malignancies, inducing notable ...
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy
The purpose of this study was to review the pharmacokinetic profile of gentamicin among neonates with hypoxic ischemic enc...
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Ketamine has been considered as an adjunct for children who do not reach their predefined target sedation depth. However, ...
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Current data on ustekinumab therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (I...
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) causes significant morbidity and mortality in children aged ≤ 5 years and...
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a potentially serious and life-threatening complication of SLE. T...
Alirocumab: Pediatric First Approval
Alirocumab: Pediatric First Approval
Alirocumab (Praluent®), a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor that has been co-developed ...
A Pilot Study of Ketotifen in Patients Aged 8–17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia
A Pilot Study of Ketotifen in Patients Aged 8–17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia
Mast cells have been implicated in abdominal pain-associated disorders of gut-brain interaction, such as functional dyspep...
Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians
Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians
The widespread use of drugs for unapproved purposes remains common in children, primarily attributable to practical, ethic...
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
To date, evidence has been lacking regarding bevacizumab pharmacokinetics in the cerebrospinal fluid (CSF). This study ass...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option
Opioid therapy is the mainstay for managing pain in pediatric oncology. This narrative review describes the current litera...
Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations
Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations
The management of vascular malformations is complex and challenging. This study aimed to explore efficacy, plasma trough c...
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Concerns exist regarding the rising use of methylphenidate. A double-blind, placebo-controlled methylphenidate titration (...
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs
Juvenile psoriatic arthritis (JPsA) is a heterogeneous type of non-systemic chronic inflammatory arthritis affecting child...
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
Anti-disialoganglioside (anti-GD2) monoclonal antibodies are effective immunotherapeutic drugs for treating neuroblastoma,...
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review
Prescribing is a high-risk task within the pediatric medication-use process and requires defenses to prevent errors. Such ...
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations
Funding No funding was received for the preparation of this...
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms
Pediatric prucalopride studies for treatment of gastrointestinal (GI) disorders have reported mixed results. We aimed to a...
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Systemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders assoc...
Managing Lupus Nephritis in Children and Adolescents
Managing Lupus Nephritis in Children and Adolescents
Lupus nephritis is an important manifestation of systemic lupus erythematosus, which leads to chronic kidney disease, kidn...
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