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Clinical Study to Evaluate the Possible Efficacy and Safety of -Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial
Clinical Study to Evaluate the Possible Efficacy and Safety of -Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial
Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can...
A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma
A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma
Takayasu arteritis (TAK) is a rare large-vessel vasculitis primarily affecting young female patients, with pediatric cases...
Association of Serum Levels of Ustekinumab, Vedolizumab, and Faecal Calprotectin in Paediatric Patients with Inflammatory Bowel Diseases: A Prospective Observational Study
Association of Serum Levels of Ustekinumab, Vedolizumab, and Faecal Calprotectin in Paediatric Patients with Inflammatory Bowel Diseases: A Prospective Observational Study
Ustekinumab (USTE) and vedolizumab (VEDO) are increasingly used in paediatric patients with inflammatory bowel diseases (p...
Physiologically Based Pharmacokinetic Modeling-Based Evaluation of Current Carbamazepine and Valproic Acid Dosing Guidelines for Pediatric Epilepsy Treatment
Physiologically Based Pharmacokinetic Modeling-Based Evaluation of Current Carbamazepine and Valproic Acid Dosing Guidelines for Pediatric Epilepsy Treatment
Carbamazepine and valproic acid (VPA) are long-standing treatments for epilepsy in children. Interestingly, they display u...
Levetiracetam Versus Fosphenytoin Infusions as Second-Line Treatment for Pediatric Status Epilepticus: A Multicenter Study Examining Effectiveness, Tolerability, and Ease of Use
Levetiracetam Versus Fosphenytoin Infusions as Second-Line Treatment for Pediatric Status Epilepticus: A Multicenter Study Examining Effectiveness, Tolerability, and Ease of Use
Status epilepticus is a life-threatening neurological emergency that requires rapid and effective treatment to prevent lon...
Long-Term Safety of Anti-Interleukin-1 Medications in Children with Rheumatic Diseases: a Systematic Review
Long-Term Safety of Anti-Interleukin-1 Medications in Children with Rheumatic Diseases: a Systematic Review
Anti-interleukin-1 (IL-1) biologic disease-modifying anti-rheumatic drugs are the mainstay for several childhood rheumatic...
Long-Term Efficacy and Safety of Secukinumab in Children and Adolescents with Moderate-to-Severe Chronic Plaque Psoriasis: Four-Year Results of a Randomized, Phase III, Open-Label Trial
Long-Term Efficacy and Safety of Secukinumab in Children and Adolescents with Moderate-to-Severe Chronic Plaque Psoriasis: Four-Year Results of a Randomized, Phase III, Open-Label Trial
The efficacy and safety of secukinumab up to week 52 in children and adolescents with moderate-to-severe chronic plaque ps...
Antipsychotic Medications for Delirium Treatment in the Pediatric Intensive Care Unit: A Systematic Review
Antipsychotic Medications for Delirium Treatment in the Pediatric Intensive Care Unit: A Systematic Review
Pediatric delirium (PD) is a common but underdiagnosed condition in pediatric intensive care units (PICUs), affecting 17&#...
Current Treatment Modalities for Urea Cycle Disorders
Current Treatment Modalities for Urea Cycle Disorders
The urea cycle, a metabolic pathway comprising six enzymes and two transporters, is necessary for mammalian nitrogen detox...
Fremanezumab: Pediatric First Approval
Fremanezumab: Pediatric First Approval
Fremanezumab (fremanezumab-vfrm; AJOVY®) is a humanized monoclonal antibody developed by Teva Pharmaceuticals to sele...
Recent Advances in the Management of Seizures in Children
Recent Advances in the Management of Seizures in Children
Childhood epilepsies comprise a group of heterogeneous conditions associated with diverse aetiologies, seizure severities/...
Vedolizumab Versus Other Biologics and the Risk of Venous Thromboembolism in Patients with Pediatric-Onset Inflammatory Bowel Diseases: A Target Trial Emulation Study
Vedolizumab Versus Other Biologics and the Risk of Venous Thromboembolism in Patients with Pediatric-Onset Inflammatory Bowel Diseases: A Target Trial Emulation Study
Pediatric-onset inflammatory bowel diseases (IBD) are associated with an elevated risk of venous thromboembolism (VTE). Ho...
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
Children treated in a pediatric intensive care unit (PICU) often receive several drugs together, among them drugs defined ...
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Congenital heart disease (CHD) is one of the leading causes of death. Safe and timely medical interventions, especially in...
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis
The efficacy and safety of propranolol for retinopathy of prematurity (ROP) remain under debate. This network meta-analysi...
Paediatric Drug Development in China: Current Status and Future Prospects
Paediatric Drug Development in China: Current Status and Future Prospects
For more than two decades, regulatory agencies throughout the world released guidelines, rules and laws to stimulate and a...
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review
Immunosuppressive medications play a crucial role in determining both organ and patient survival following liver transplan...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells...
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
Antiseizure medications (ASMs) can potentially trigger psychobehavioral adverse events associated with the onset or exacer...
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Vamorolone has recently been approved for the management of Duchenne muscular dystrophy to replace glucocorticosteroids, w...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
This narrative review examines the evolving role of opioids in managing procedural and surgical pain in pediatric oncology...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure ...
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematological malignancies, inducing notable ...
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy
Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy
The purpose of this study was to review the pharmacokinetic profile of gentamicin among neonates with hypoxic ischemic enc...
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Ketamine has been considered as an adjunct for children who do not reach their predefined target sedation depth. However, ...
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Current data on ustekinumab therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (I...
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) causes significant morbidity and mortality in children aged ≤ 5 years and...
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a potentially serious and life-threatening complication of SLE. T...
Alirocumab: Pediatric First Approval
Alirocumab: Pediatric First Approval
Alirocumab (Praluent®), a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor that has been co-developed ...
A Pilot Study of Ketotifen in Patients Aged 8–17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia
A Pilot Study of Ketotifen in Patients Aged 8–17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia
Mast cells have been implicated in abdominal pain-associated disorders of gut-brain interaction, such as functional dyspep...
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