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Natural organosulfur compound inhibits cervical cancer cell activity in-vitro and restrict their receptor–gene interactions via computational approach
Natural organosulfur compound inhibits cervical cancer cell activity in-vitro and restrict their receptor–gene interactions via computational approach
Cervical cancer is the fourth most common cancer among women which remains a significant global health issue, primarily ca...
The value of prognostic nutritional index in predicting the survival of Egyptian patients with advanced hepatocellular carcinoma treated with sorafenib and regorafenib
The value of prognostic nutritional index in predicting the survival of Egyptian patients with advanced hepatocellular carcinoma treated with sorafenib and regorafenib
This investigation aims to assess the prognostic significance of the pre-therapeutic prognostic nutritional index (PNI) in...
Molecular insights in potentiation of antibiotic activity by apple cider vinegar in diabetic wound pathogens
Molecular insights in potentiation of antibiotic activity by apple cider vinegar in diabetic wound pathogens
The prevalence of antibiotic resistance has become a critical global health concern. In particular, resistant strains of S...
Dapagliflozin effect on anemia outcomes in patients with diabetes and CKD
Dapagliflozin effect on anemia outcomes in patients with diabetes and CKD
Anemia is a prevalent complication in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), cont...
Stability indicating eco-friendly HPLC method development and validation for the estimation of bisoprolol fumarate and telmisartan
Stability indicating eco-friendly HPLC method development and validation for the estimation of bisoprolol fumarate and telmisartan
Telmisartan and bisoprolol fumarate together are two medications that diminish arterial pressure. The current study compri...
Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1
Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1
Lead (Pb) is a heavy metal with extreme toxicity and numerous industrial uses. It produces nephrotoxicity with notable cha...
Novel tetracycline hybrids: synthesis, characterization, docking studies and in-vitro evaluation of antibacterial activity
Novel tetracycline hybrids: synthesis, characterization, docking studies and in-vitro evaluation of antibacterial activity
The biggest menace in the world today is the infection caused by pathogenic bacteria in humans, where majority of the avai...
Evaluation of efficacy and safety of coenzyme Q10 in pediatric hemodialysis patients: a randomized controlled trial
Evaluation of efficacy and safety of coenzyme Q10 in pediatric hemodialysis patients: a randomized controlled trial
There is evidence from clinical trials that coenzyme Q10 significantly improves mitochondrial function and decreases oxida...
Natural products targeting ubiquitination to combat kidney fibrosis
Natural products targeting ubiquitination to combat kidney fibrosis
Kidney fibrosis is a crucial component that contributes to end-stage renal disease and is the inevitable last pathological...
Evaluation of the effect of pentoxifylline on the prevention of paclitaxel‑induced peripheral neuropathy in breast cancer patients: a randomized controlled study
Evaluation of the effect of pentoxifylline on the prevention of paclitaxel‑induced peripheral neuropathy in breast cancer patients: a randomized controlled study
Paclitaxel-induced peripheral neuropathy (PIPN) is one of the most common and debilitating toxicity. Up till now, no treat...
Simultaneous estimation of nebivolol hydrochloride and amlodipine besylate in human plasma employing an innovative HPLC chromatographic method
Simultaneous estimation of nebivolol hydrochloride and amlodipine besylate in human plasma employing an innovative HPLC chromatographic method
This study developed and validated a simple, robust, and cost-effective RP-HPLC bioanalytical method for the determination...
Effect of crude ethanolic seed extract from Mucuna pruriens on proliferation, apoptosis, and cell cycle arrest in gastric adenocarcinoma (AGS) cells
Effect of crude ethanolic seed extract from Mucuna pruriens on proliferation, apoptosis, and cell cycle arrest in gastric adenocarcinoma (AGS) cells
Gastric cancer is a prevalent form of malignancy among many common carcinoma cases globally. This study was designed to as...
α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells
α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells
α-Mangostin is a major xanthone in Garcinia mangostana L. (Clusiaceae) pericarps. It has promising anti-prol...
Artesunate-driven autophagy: a shield against liver hypoxia/reoxygenation insult in rats via modulation of GLP1R, the chief metabolic kinase AMPK, mTOR, ULK1, P70S6K, cyclin D1, Akt, and GSK3β
Artesunate-driven autophagy: a shield against liver hypoxia/reoxygenation insult in rats via modulation of GLP1R, the chief metabolic kinase AMPK, mTOR, ULK1, P70S6K, cyclin D1, Akt, and GSK3β
Hepatic hypoxia/reoxygenation (H/R) insult is a critical issue in hepatic transplant and surgeries, profoundly influencing...
Green analytical chemistry-based spectrophotometric techniques for ternary component analysis of pain relievers
Green analytical chemistry-based spectrophotometric techniques for ternary component analysis of pain relievers
The management of pain presents a significant challenge in healthcare, particularly in cases where conventional therapies ...
Diverse pharmacological actions of potential carbazole derivatives by influencing various pathways of molecular signaling
Diverse pharmacological actions of potential carbazole derivatives by influencing various pathways of molecular signaling
Carbazoles are an important class of heterocyclic aromatic compounds that contain nitrogen atom in the ring. They have a l...
A critical examination of advanced approaches in green chemistry: microbial bioremediation strategies for sustainable mitigation of plastic pollution
A critical examination of advanced approaches in green chemistry: microbial bioremediation strategies for sustainable mitigation of plastic pollution
The escalating concern regarding the environmental impact of plastic waste necessitates the adoption of biodegradable meth...
Hypoglycemic and hepatoprotective activity of Phellinus fastuosus on streptozotocin-induced diabetic rats and carbon tetrachloride-intoxicated rats, respectively
Hypoglycemic and hepatoprotective activity of Phellinus fastuosus on streptozotocin-induced diabetic rats and carbon tetrachloride-intoxicated rats, respectively
Phellinus fastuosus is a wood-eating medicinal fungus from Western Ghats of India. Therefore, we investigated hypoglycemic...
Quantum chemical modelling, molecular docking, synthesis and experimental anti-microbial activity of 1,4-diazepan linked piperidine derivative
Quantum chemical modelling, molecular docking, synthesis and experimental anti-microbial activity of 1,4-diazepan linked piperidine derivative
In this work, we represent synthesis, in silico analysis and biological activity of 1,4 diazepine linked piperidine deriva...
In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma
In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma
Diffuse astrocytoma (a type of glioma) and its prevalence are matters of concern worldwide. Patients with this type of tum...
A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study
A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study
Carivalan® dosage form containing carvedilol and ivabradine is widely indicated for patients with stable angina. Thre...
Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study
Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study
Pharmacists have an important role in preventing prescribing errors and providing appropriate information. They can detect...
Screening and characterization of bioactive compounds from two epiphytic microlichen and evaluation of their in vitro antioxidant activity
Screening and characterization of bioactive compounds from two epiphytic microlichen and evaluation of their in vitro antioxidant activity
Lichens in symbiosis produce a wide range of primary and secondary fine compounds in extreme environmental conditions that...
Chemical profiling of antifungal Dicerocaryum senecioides and Diospyros mespiliformis extracts using TLC-p-iodonitrotetrazolium violet assay and GC–MS/MS
Chemical profiling of antifungal Dicerocaryum senecioides and Diospyros mespiliformis extracts using TLC-p-iodonitrotetrazolium violet assay and GC–MS/MS
Despite the availability of conventional medication for fungal skin diseases, dermatophytic infections are now a major cri...
Inhibitory capacity of extracts and main constituents of hop flowers
Inhibitory capacity of extracts and main constituents of hop flowers
Hops (Humulus lupulus Linn.) produce flowers that are used on an industrial scale to impart sensory properties to beer and...
QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers
QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers
In cancer therapies, chemo-herbal combinations are receiving increased attention. A multiple tyrosine kinase inhibitor, le...
Development of novel gradient RP-HPLC method for separation of dapagliflozin and its process-related impurities: insight into stability profile and degradation pathway, identification of degradants using LCMS
Development of novel gradient RP-HPLC method for separation of dapagliflozin and its process-related impurities: insight into stability profile and degradation pathway, identification of degradants using LCMS
In the dapagliflozin (DPF) synthesis, 5-Bromo-2-chlorobenzoic acid (5-BC impurity) and 4-Bromo-1-chloro-2-(4-ethoxybenzyl)...
Peptide-modified PAMAM-based bone-targeting RNA delivery system
Peptide-modified PAMAM-based bone-targeting RNA delivery system
Osteoporosis, among other bone diseases, has become a prevalent cause of decreased quality of life in older and postmenopa...
A validated RP-UPLC method for estimation of Samidorphan and Olanzapine in mixed powder and combined tablets
A validated RP-UPLC method for estimation of Samidorphan and Olanzapine in mixed powder and combined tablets
The key objective of the research study is to develop a new stability-indicating RP-UPLC approach to determine the presenc...
A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration
A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration
Since long, triamcinolone and fluocinolone, fluorinated derivatives, have been used for treating various types of dermatit...
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