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HER-2 SMASH
HER-2 SMASH
Human epidermal growth factor-2 (HER-2) targeted drugs are used in only HER-2 overexpressed cancers. However, only a small...
Evaluation of urinary vanin-1 for the early prediction of cisplatin-induced acute kidney injury during neoadjuvant chemotherapy for esophageal cancer
Evaluation of urinary vanin-1 for the early prediction of cisplatin-induced acute kidney injury during neoadjuvant chemotherapy for esophageal cancer
Cisplatin (CDDP) induces acute kidney injury (AKI) as a side effect during neoadjuvant chemotherapy (NAC). Urinary vanin-1...
Variations in serum concentrations of sunitinib and its metabolites in patients receiving long-term sunitinib treatment
Variations in serum concentrations of sunitinib and its metabolites in patients receiving long-term sunitinib treatment
The blood concentrations of some tyrosine kinase inhibitors are known to decrease with long-term administration. We evalua...
Pharmacokinetics of cisplatin in the systemic versus hyperthermic intrathoracic or intraperitoneal chemotherapy
Pharmacokinetics of cisplatin in the systemic versus hyperthermic intrathoracic or intraperitoneal chemotherapy
To compare the pharmacokinetics and adverse effects of cisplatin administered via intravenous infusion for systemic chemot...
Tenuigenin inhibits osteosarcoma growth via CIP2A/PP2A/NF-κB axis
Tenuigenin inhibits osteosarcoma growth via CIP2A/PP2A/NF-κB axis
Polygala tenuifolia and its active components have been revealed to possess anti-tumor activities. However, the role of Te...
DPYD genotype should be extended to rare variants: report on two cases of phenotype / genotype discrepancy
DPYD genotype should be extended to rare variants: report on two cases of phenotype / genotype discrepancy
The enzyme dihydropyrimidine dehydrogenase (DPD) is the primary catabolic pathway of fluoropyrimidines including 5 fluorou...
Nanotechnology and nanobots unleashed: pioneering a new era in gynecological cancer management – a comprehensive review
Nanotechnology and nanobots unleashed: pioneering a new era in gynecological cancer management – a comprehensive review
Gynecological cancers, such as ovarian, cervical, and endometrial malignancies, are notoriously challenging due to their i...
Landscape analysis of adverse events and dose intensity for FDA approved oncology small molecules
Landscape analysis of adverse events and dose intensity for FDA approved oncology small molecules
As development of new oncology small molecule therapies is focused mainly on molecularly targeted agents, the dose selecti...
Pharmacokinetics, mass balance, and metabolism of [14C]PLB1004, a selective and irreversible EGFR-TKI in humans
Pharmacokinetics, mass balance, and metabolism of [14C]PLB1004, a selective and irreversible EGFR-TKI in humans
PLB1004, developed by Beijing Avistone Biotechnology Co., Ltd., is a safe, highly selective, and efficient irreversible ep...
Endoglin as a predictive biomarker for pemetrexed sensitivity in non-small-cell lung cancer: a cellular study
Endoglin as a predictive biomarker for pemetrexed sensitivity in non-small-cell lung cancer: a cellular study
Based on our previous research, which demonstrated that elevated plasma endoglin (ENG) levels in lung cancer patients were...
Targeting on the PI3K/mTOR: a potential treatment strategy for clear cell ovarian carcinoma
Targeting on the PI3K/mTOR: a potential treatment strategy for clear cell ovarian carcinoma
Ovarian clear cell carcinoma is a highly malignant gynecological tumor characterized by a high rate of chemotherapy resist...
A phase I study of MLN4924 and belinostat in relapsed/refractory acute myeloid leukemia or myelodysplastic syndrome
A phase I study of MLN4924 and belinostat in relapsed/refractory acute myeloid leukemia or myelodysplastic syndrome
Relapsed and/or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome continue to have a poor prognosis...
WT161, a selective HDAC6 inhibitor, decreases growth, enhances chemosensitivity, promotes apoptosis, and suppresses motility of melanoma cells
WT161, a selective HDAC6 inhibitor, decreases growth, enhances chemosensitivity, promotes apoptosis, and suppresses motility of melanoma cells
Histone deacetylase 6 (HDAC6) plays a critical role in tumorigenesis and tumor progression, contributing to proliferation,...
Population pharmacokinetics and exposure-response analysis of durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer
Population pharmacokinetics and exposure-response analysis of durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer
Durvalumab in combination with gemcitabine/cisplatin has shown a favorable benefit-risk profile in the TOPAZ-1 study for a...
Pharmacokinetic exposure and treatment outcomes of lenvatinib in patients with renal cell carcinoma and differentiated thyroid carcinoma
Pharmacokinetic exposure and treatment outcomes of lenvatinib in patients with renal cell carcinoma and differentiated thyroid carcinoma
After initial approval of lenvatinib for radioiodine-refractory differentiated thyroid cancer (DTC), it has also shown pro...
Dihydropyrimidine enzyme activity and its effect on chemotherapy toxicity: importance of genetic testing
Dihydropyrimidine enzyme activity and its effect on chemotherapy toxicity: importance of genetic testing
Patients with partial or complete DPD deficiency have decreased capacity to degrade fluorouracil and are at risk of develo...
Phase I trial of ATR inhibitor elimusertib with FOLFIRI in advanced or metastatic gastrointestinal malignancies (ETCTN 10406)
Phase I trial of ATR inhibitor elimusertib with FOLFIRI in advanced or metastatic gastrointestinal malignancies (ETCTN 10406)
ATR is an apical DDR kinase activated at damaged replication forks. Elimusertib is an oral ATR inhibitor and potentiates i...
HMGB1 assists the predictive value of tumor PD-L1 expression for the efficacy of anti-PD-1/PD-L1 antibody in NSCLC
HMGB1 assists the predictive value of tumor PD-L1 expression for the efficacy of anti-PD-1/PD-L1 antibody in NSCLC
The expression of anti-programmed cell death ligand-1 (PD-L1) in tumors is widely used as a biomarker to predict the thera...
Lipidomic profiling of plasma from patients with multiple myeloma receiving bortezomib: an exploratory biomarker study of JCOG1105 (JCOG1105A1)
Lipidomic profiling of plasma from patients with multiple myeloma receiving bortezomib: an exploratory biomarker study of JCOG1105 (JCOG1105A1)
A comprehensive analysis of metabolites (metabolomics) has been proposed as a new strategy for analyzing liquid biopsies a...
Acute kidney injury in a child treated with cisplatin and amphotericin B
Acute kidney injury in a child treated with cisplatin and amphotericin B
Cisplatin and amphotericin B are both known to be potentially nephrotoxic. We describe acute kidney injury due to the comb...
Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2
Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2
Hair cell damage is a common side effect caused by the anticancer drug cisplatin (CDDP), which reduces patient quality of ...
Ferroptosis – a potential feature underlying neratinib-induced colonic epithelial injury
Ferroptosis – a potential feature underlying neratinib-induced colonic epithelial injury
Neratinib, a small-molecule tyrosine kinase inhibitor (TKI) that irreversibly binds to human epidermal growth factor recep...
Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma
Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive malignancies. Our previous work revealed Chitinase 3-...
Advancements in physiologically based pharmacokinetic modeling for fedratinib: updating dose guidance in the presence of a dual inhibitor of CYP3A4 and CYP2C19
Advancements in physiologically based pharmacokinetic modeling for fedratinib: updating dose guidance in the presence of a dual inhibitor of CYP3A4 and CYP2C19
A physiologically based pharmacokinetic (PBPK) model for fedratinib was updated and revalidated to bridge a gap between th...
Pharmacogenomic associations of cyclophosphamide pharmacokinetic candidate genes with 4hydroxycyclophosphamide formation in children with Cancer
Pharmacogenomic associations of cyclophosphamide pharmacokinetic candidate genes with 4hydroxycyclophosphamide formation in children with Cancer
4-hydroxycyclophosphamide (4HCY) is the principal precursor to the cytotoxic metabolite of cyclophosphamide (CY), which is...
Successful use of Palbociclib combined with Venetoclax and Azacitidine in an adult with refractory/relapsed therapy-related acute myeloid leukemia
Successful use of Palbociclib combined with Venetoclax and Azacitidine in an adult with refractory/relapsed therapy-related acute myeloid leukemia
Therapy-related acute myeloid leukemia (t-AML) is considered high risk as it related to prior exposure to cytotoxic chemot...
Low serum concentrations of bevacizumab and nivolumab owing to excessive urinary loss in patients with proteinuria: a case series
Low serum concentrations of bevacizumab and nivolumab owing to excessive urinary loss in patients with proteinuria: a case series
Proteinuria can cause interindividual variability in the pharmacokinetics of therapeutic antibodies and may affect therape...
Continuous exposure to doxorubicin induces stem cell-like characteristics and plasticity in MDA-MB-231 breast cancer cells identified with the SORE6 reporter
Continuous exposure to doxorubicin induces stem cell-like characteristics and plasticity in MDA-MB-231 breast cancer cells identified with the SORE6 reporter
Cancer stem cells (CSCs) account for recurrence and resistance to breast cancer drugs, rendering them a cause of mortality...
A comparison of the renal function biomarkers serum creatinine, pro-enkephalin and cystatin C to predict clearance of pemetrexed
A comparison of the renal function biomarkers serum creatinine, pro-enkephalin and cystatin C to predict clearance of pemetrexed
For drugs with a narrow therapeutic window, there is a delicate balance between efficacy and toxicity, thus it is pivotal ...
An interactive dose optimizer based on population pharmacokinetic study to guide dosing of methotrexate in Chinese patients with osteosarcoma
An interactive dose optimizer based on population pharmacokinetic study to guide dosing of methotrexate in Chinese patients with osteosarcoma
Osteosarcoma is a rare tumor with an incidence of 4.4 cases per million per year in adolescent. High-dose methotrexate (HD...
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