Tenuigenin inhibits osteosarcoma growth via CIP2A/PP2A/NF-κB axis

Czarnecka AM, Synoradzki K, Firlej W, Bartnik E, Sobczuk P, Fiedorowicz M, Grieb P, Rutkowski P (2020) Molecular biology of osteosarcoma. Cancers (Basel). https://doi.org/10.3390/cancers12082130

Article  PubMed  PubMed Central  Google Scholar 

Chen C, Xie L, Ren T, Huang Y, Xu J, Guo W (2021) Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs. Cancer Lett 500:1–10. https://doi.org/10.1016/j.canlet.2020.12.024

Article  CAS  PubMed  Google Scholar 

Argenziano M, Tortora C, Pota E, Di Paola A, Di Martino M, Di Leva C, Di Pinto D, Rossi F (2021) Osteosarcoma in children: not only chemotherapy. Pharmaceuticals (Basel). https://doi.org/10.3390/ph14090923

Article  PubMed  Google Scholar 

Jin ML, Lee DY, Um Y, Lee JH, Park CG, Jetter R, Kim OT (2014) Isolation and characterization of an oxidosqualene cyclase gene encoding a beta-amyrin synthase involved in Polygala tenuifolia Willd saponin biosynthesis. Plant Cell Rep. https://doi.org/10.1007/s00299-013-1554-7

Article  PubMed  Google Scholar 

Deng X, Zhao S, Liu X, Han L, Wang R, Hao H, Jiao Y, Han S, Bai C (2020) Polygala tenuifolia: a source for anti-Alzheimer’s disease drugs. Pharm Biol 58(1):410–416. https://doi.org/10.1080/13880209.2020.1758732

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bian Y, Zeng H, Tao H, Huang L, Du Z, Wang J, Ding K (2020) A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy. Int J Biol Macromol 162:107–115. https://doi.org/10.1016/j.ijbiomac.2020.06.054

Article  CAS  PubMed  Google Scholar 

Yu S, Dong X, Ji H, Yu J, Liu A (2021) Antitumor activity and immunomodulation mechanism of a novel polysaccharide extracted from Polygala tenuifolia Willd. evaluated by S180 cells and S180 tumor-bearing mice. Int J Biol Macromol 192:546–556. https://doi.org/10.1016/j.ijbiomac.2021.10.025

Article  CAS  PubMed  Google Scholar 

Zhang F, Song X, Li L, Wang J, Lin L, Li C, Li H, Lv Y, Jin Y, Liu Y, Hu Y, Xin T (2015) Polygala tenuifolia polysaccharide PTP induced apoptosis in ovarian cancer cells via a mitochondrial pathway. Tumour Biol 36(4):2913–2919. https://doi.org/10.1007/s13277-014-2921-x

Article  CAS  PubMed  Google Scholar 

Chen Z, Yang Y, Han Y, Wang X (2022) Neuroprotective effects and mechanisms of senegenin, an effective compound originated from the roots of polygala tenuifolia. Front Pharmacol 13:937333. https://doi.org/10.3389/fphar.2022.937333

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Q, Lenardo MJ, Baltimore D (2017) 30 years of NF-kappaB: a blossoming of relevance to human pathobiology. Cell 168(1–2):37–57. https://doi.org/10.1016/j.cell.2016.12.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lalle G, Twardowski J, Grinberg-Bleyer Y (2021) NF-kappaB in cancer immunity: friend or foe? Cells. https://doi.org/10.3390/cells10020355

Article  PubMed  PubMed Central  Google Scholar 

Gong Y, Yang C, Wei Z, Liu J (2022) SRPK1 promotes cell proliferation and tumor growth of osteosarcoma through activation of the NF-kappaB signaling pathway. Biol Chem 403(7):653–663. https://doi.org/10.1515/hsz-2020-0394

Article  CAS  PubMed  Google Scholar 

Zhou JL, Deng S, Fang HS, Yu G, Peng H (2019) Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway. Biomed Pharmacother 109:2335–2341. https://doi.org/10.1016/j.biopha.2018.11.026

Article  CAS  PubMed  Google Scholar 

Yu B, Qiao J, Shen Y, Li L (2017) Protective effects of tenuigenin on Staphylococcus aureus-induced pneumonia in mice. Microb Pathog 110:385–389. https://doi.org/10.1016/j.micpath.2017.07.023

Article  CAS  PubMed  Google Scholar 

Wang C, Zeng L, Zhang T, Liu J, Wang W (2016) Tenuigenin Prevents IL-1beta-induced inflammation in human osteoarthritis chondrocytes by suppressing PI3K/AKT/NF-kappaB signaling pathway. Inflammation 39(2):807–812. https://doi.org/10.1007/s10753-016-0309-3

Article  CAS  PubMed  Google Scholar 

Xu C, Tang J, Yang Q, Zhao H, Liu Y, Cao J, Zhou Y, Chen X, Chen J (2021) Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling. J Biol Chem 297(6):101380. https://doi.org/10.1016/j.jbc.2021.101380

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kohyanagi N, Kitamura N, Ikeda S, Shibutani S, Sato K, Ohama T (2024) PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells. J Biol Chem. https://doi.org/10.1016/j.jbc.2023.105584

Article  PubMed  Google Scholar 

Soofiyani SR, Hejazi MS, Baradaran B (2017) The role of CIP2A in cancer: a review and update. Biomed Pharmacother 96:626–633. https://doi.org/10.1016/j.biopha.2017.08.146

Article  CAS  PubMed  Google Scholar 

Binbin Hu DZ, Zhao K, Wang Y, Pei L, Qianmei Fu, Ma X (2021) Spotlight on USP4: structure, function, and regulation. Front Cell Dev Biol 9:595159

Article  PubMed  PubMed Central  Google Scholar 

Ji Z, Shen J, Lan Y, Yi Q (2020) Liu H (2023) Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies. MedComm. https://doi.org/10.1002/mco2.308

Article  Google Scholar 

Panez-Toro I, Munoz-Garcia J, Vargas-Franco JW, Renodon-Corniere A, Heymann MF, Lezot F, Heymann D (2023) Advances in osteosarcoma. Curr Osteoporos Rep 21(4):330–343. https://doi.org/10.1007/s11914-023-00803-9

Article  PubMed  PubMed Central  Google Scholar 

Fan Z, Liang Z, Yang H, Pan Y, Zheng Y, Wang X (2017) Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia. J Neuroinflammation 14(1):256. https://doi.org/10.1186/s12974-017-1036-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian Y, Qi Y, Cai H, Xu M, Zhang Y (2022) Senegenin alleviates Abeta(1–42) induced cell damage through triggering mitophagy. J Ethnopharmacol 295:115409. https://doi.org/10.1016/j.jep.2022.115409

Article  CAS  PubMed  Google Scholar 

Yao H, Cui P, Xu D, Liu Y, Tian Q, Zhang F (2018) A water-soluble polysaccharide from the roots of Polygala tenuifolia suppresses ovarian tumor growth and angiogenesis in vivo. Int J Biol Macromol. https://doi.org/10.1016/j.ijbiomac.2017.09.043

Article  PubMed  Google Scholar 

Chen D, Fan S, Wang J, Liang Y, Li P, Lv X, Sun Y, Wang Q, Liu H, Zhang C, Yi Y (2023) Cip2a induces arginine biosynthesis and promotes tumor progression in non-small cell lung cancer. Mol Carcinog 62(4):561–572. https://doi.org/10.1002/mc.23507

Article  CAS  PubMed  Google Scholar 

Chen W, Liang JL, Zhou K, Zeng QL, Ye JW, Huang MJ (2020) Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer. Cell Commun Signal 18(1):67. https://doi.org/10.1186/s12964-020-00545-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Z, Chen X, Hegazy AM, Zhang S, Liu X, Tian J, Wu J, Shi F, Li L, Niu X, Pu J (2021) Depletion of CIP2A inhibits the proliferation, migration, invasion and epithelial-mesenchymal transition of glioma cells. Brain Res Bull 173:14–21. https://doi.org/10.1016/j.brainresbull.2021.04.009

Article  CAS  PubMed  Google Scholar 

Liu X, Sun Z, Deng J, Liu J, Ma K, Si Y, Zhang T, Feng T, Liu Y, Tan Y (2018) Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer. Int J Oncol 5

Comments (0)

No login
gif