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Comparative Effectiveness of Different Opioid Regimens, in Daily Dose or Treatment Duration, Prescribed at Surgical Discharge: a Systematic Review and Meta-Analysis
Comparative Effectiveness of Different Opioid Regimens, in Daily Dose or Treatment Duration, Prescribed at Surgical Discharge: a Systematic Review and Meta-Analysis
Opioids are prescribed for postsurgical pain management, but a balance between achieving adequate pain control and minimis...
Update on Neuroprotection after Traumatic Brain Injury
Update on Neuroprotection after Traumatic Brain Injury
Traumatic brain injury (TBI) is a prevalent cause of morbidity and mortality worldwide. A focus on neuroprotective agents ...
Efficacy of Once-Nightly Sodium Oxybate in Patients with Narcolepsy: Post Hoc Analyses of Sensitivity, Effect Size, and Numbers Needed to Treat from the Phase 3 REST-ON Trial
Efficacy of Once-Nightly Sodium Oxybate in Patients with Narcolepsy: Post Hoc Analyses of Sensitivity, Effect Size, and Numbers Needed to Treat from the Phase 3 REST-ON Trial
Once-nightly sodium oxybate (ON-SXB; LUMRYZ™; FT218) treatment significantly improved the coprimary endpoints of mea...
Is the Effect of Intensive Antihypertensive Treatment in Acute Intracerebral Hemorrhage Dependent on Hematoma Volume? A Traditional Meta-analysis of the Effect of Antihypertensive Regimens, a Bayesian Network Meta-analysis of the Mortality of Antihypertensive Drugs and Systematic Review
Is the Effect of Intensive Antihypertensive Treatment in Acute Intracerebral Hemorrhage Dependent on Hematoma Volume? A Traditional Meta-analysis of the Effect of Antihypertensive Regimens, a Bayesian Network Meta-analysis of the Mortality of Antihypertensive Drugs and Systematic Review
Intensive or conventional antihypertensive treatment for acute intracerebral hemorrhage is still controversial. This study...
A New Dawn in the Management of Narcolepsy
A New Dawn in the Management of Narcolepsy
The sleep disorder was first described in the medical literature by Dr. Karl Friedric...
Assessing Early Efficacy After Initiation of Once-Nightly Sodium Oxybate (ON-SXB; FT218) in Participants with Narcolepsy Type 1 or 2: A Post Hoc Analysis from the Phase 3 REST-ON Trial
Assessing Early Efficacy After Initiation of Once-Nightly Sodium Oxybate (ON-SXB; FT218) in Participants with Narcolepsy Type 1 or 2: A Post Hoc Analysis from the Phase 3 REST-ON Trial
Once-nightly sodium oxybate (LUMRYZ™; ON-SXB; FT218) significantly improved narcolepsy symptoms in the phase 3 REST-...
Narcolepsy: Beyond the Classic Pentad
Narcolepsy: Beyond the Classic Pentad
Narcolepsy is a rare, disabling, chronic neurologic disorder that requires lifelong management of symptoms with pharmacolo...
Therapeutic Use of γ-Hydroxybutyrate: History and Clinical Utility of Oxybates and Considerations of Once- and Twice-Nightly Dosing in Narcolepsy
Therapeutic Use of γ-Hydroxybutyrate: History and Clinical Utility of Oxybates and Considerations of Once- and Twice-Nightly Dosing in Narcolepsy
Narcolepsy is a rare and chronic hypersomnolence disorder characterized by excessive daytime sleepiness, disrupted nightti...
A Survey of People Living with Narcolepsy in the USA: Path to Diagnosis, Quality of Life, and Treatment Landscape from the Patient’s Perspective
A Survey of People Living with Narcolepsy in the USA: Path to Diagnosis, Quality of Life, and Treatment Landscape from the Patient’s Perspective
Narcolepsy is a chronic, burdensome neurologic disorder that significantly impacts the daily life of people with narcoleps...
Sodium Oxybate: Practical Considerations and Patient Perspectives
Sodium Oxybate: Practical Considerations and Patient Perspectives
Narcolepsy is a rare, chronic sleep disorder with significant impacts on the quality of life of people affected by the dis...
Clozapine-Related Tachycardia: An Analysis of Incidence
Clozapine-Related Tachycardia: An Analysis of Incidence
Sinus tachycardia commonly occurs at the start of clozapine treatment, often leading to discontinuation owing to perceived...
Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail
Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail
Opioid analgesics have been used for more than 5000 years and remain the main pain medications prescribed today. Although ...
The Evolution of Anti-CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function
The Evolution of Anti-CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function
B-cell depletion with CD20-targeted agents is commonly used for treatment of multiple sclerosis (MS), other autoimmune dis...
Foslevodopa/Foscarbidopa: A Review in Advanced Parkinson’s Disease
Foslevodopa/Foscarbidopa: A Review in Advanced Parkinson’s Disease
Foslevodopa/foscarbidopa [PRODUODOPA® (EU); VYALEV™ (USA, Canada, Japan)] is a soluble formulation of levodopa ...
Comparative Efficacy and Safety of Multiple Wake-Promoting Agents for the Treatment of Residual Sleepiness in Obstructive Sleep Apnea Despite Continuous Positive Airway Pressure: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Comparative Efficacy and Safety of Multiple Wake-Promoting Agents for the Treatment of Residual Sleepiness in Obstructive Sleep Apnea Despite Continuous Positive Airway Pressure: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Residual sleepiness can occur in adult patients with obstructive sleep apnea (OSA) despite adequate treatment with continu...
Effect of Naltrexone on Spinal and Supraspinal Pain Mechanisms and Functional Capacity in Women with Fibromyalgia: Exploratory Outcomes from the Randomized Placebo-Controlled FINAL Trial
Effect of Naltrexone on Spinal and Supraspinal Pain Mechanisms and Functional Capacity in Women with Fibromyalgia: Exploratory Outcomes from the Randomized Placebo-Controlled FINAL Trial
The widespread pain and muscular fatigue characteristics of fibromyalgia are believed to be mediated by central mechanisms...
Cenobamate: A Review in Focal-Onset Seizures
Cenobamate: A Review in Focal-Onset Seizures
Cenobamate (Ontozry®) is a once-daily oral antiseizure medication (ASM) approved in the EU for the adjunctive treatme...
Evaluation of Safety, Pharmacokinetic, and Pharmacodynamic Characteristics of a Novel Dual mGluR5/5-HT2AR Antagonist (VVZ-2471) in a Randomized, Double-Blind, First-in-Human Study
Evaluation of Safety, Pharmacokinetic, and Pharmacodynamic Characteristics of a Novel Dual mGluR5/5-HT2AR Antagonist (VVZ-2471) in a Randomized, Double-Blind, First-in-Human Study
VVZ-2471 is a dual-target compound that simultaneously inhibits both metabotropic glutamate receptor subtype 5 and seroton...
The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review
The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review
GABA (γ-aminobutyric acid) receptors are constituents of many inhibitory synapses within the central nervous system. ...
An Open-Label Extension Study Assessing the Long-Term Safety and Efficacy of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
An Open-Label Extension Study Assessing the Long-Term Safety and Efficacy of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
Viloxazine ER (extended-release capsules; Qelbree®) is a nonstimulant medication that has been approved by the United...
Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial
Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial
Although there are several treatments for narcolepsy type 2 and idiopathic hypersomnia, studies that assess amphetamines, ...
Ozanimod: A Review in Relapsing Forms of Multiple Sclerosis
Ozanimod: A Review in Relapsing Forms of Multiple Sclerosis
Ozanimod (Zeposia®), an orally administered sphingosine 1-phosphate (S1P) receptor modulator (S1PRM) that is selectiv...
Glutamatergic Modulators for Major Depression from Theory to Clinical Use
Glutamatergic Modulators for Major Depression from Theory to Clinical Use
Major depressive disorder (MDD) is a chronic, burdensome, highly prevalent disease that is characterized by depressed mood...
Current Landscape of NTRK Inhibition for Pediatric CNS Tumors
Current Landscape of NTRK Inhibition for Pediatric CNS Tumors
Over the last decade, as molecular platforms have permitted the characterization of the genomic landscape of pediatric cen...
Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study
Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study
Spinal cord lesions in multiple sclerosis (MS) have considerable impact on disability. High-efficacy disease-modifying tre...
TICA-CLOP STUDY: Ticagrelor Versus Clopidogrel in Acute Moderate and Moderate-to-Severe Ischemic Stroke, a Randomized Controlled Multi-Center Trial
TICA-CLOP STUDY: Ticagrelor Versus Clopidogrel in Acute Moderate and Moderate-to-Severe Ischemic Stroke, a Randomized Controlled Multi-Center Trial
Many studies evaluated the efficacy and safety of ticagrelor versus clopidogrel in patients with ischemic stroke; none of ...
Comparative Safety of Antipsychotic Medications and Mood Stabilizers During Pregnancy: A Systematic Review and Network Meta-analysis of Congenital Malformations and Prenatal Outcomes
Comparative Safety of Antipsychotic Medications and Mood Stabilizers During Pregnancy: A Systematic Review and Network Meta-analysis of Congenital Malformations and Prenatal Outcomes
A network meta-analysis was performed to evaluate the risk of congenital malformations and other prenatal outcomes in fetu...
Research Progress on NMDA Receptor Enhancement Drugs for the Treatment of Depressive Disorder
Research Progress on NMDA Receptor Enhancement Drugs for the Treatment of Depressive Disorder
Major depressive disorder (MDD) is a severe mental illness with a complex etiology. Currently, many medications employed i...
Recent Advances in Pharmacologic Treatments of Drug-Resistant Epilepsy: Breakthrough in Sight
Recent Advances in Pharmacologic Treatments of Drug-Resistant Epilepsy: Breakthrough in Sight
Epilepsy affects approximately 1% of the world population. Patients have recurrent seizures, increased physical and psychi...
A Multicenter, Open-Label Study to Evaluate the Long-term Safety and Efficacy of Adjunctive Brexpiprazole 2 mg Daily in Japanese Patients with Major Depressive Disorder
A Multicenter, Open-Label Study to Evaluate the Long-term Safety and Efficacy of Adjunctive Brexpiprazole 2 mg Daily in Japanese Patients with Major Depressive Disorder
Inadequate response to antidepressant monotherapy is common among patients with major depressive disorder (MDD). The effic...
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