Scammell TE. Narcolepsy. N Engl J Med. 2015;373:2654–62.

Article  CAS  PubMed  Google Scholar 

Ahmed I, Thorpy M. Clinical features, diagnosis and treatment of narcolepsy. Clin Chest Med. 2010;31:371–81.

Article  PubMed  Google Scholar 

Bassetti CLA, Adamantidis A, Burdakov D, et al. Narcolepsy-clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol. 2019;15:519–39.

Article  PubMed  Google Scholar 

Bassetti CLA, Kallweit U, Vignatelli L, et al. European guideline and expert statements on the management of narcolepsy in adults and children. Eur J Neurol. 2021;28:2815–30.

Article  PubMed  Google Scholar 

Thorpy MJ, Hiller G. The medical and economic burden of narcolepsy: Implications for managed care. Am Health Drug Benefits. 2017;10:233–41.

PubMed  PubMed Central  Google Scholar 

Ohayon MM, Thorpy MJ, Carls G, et al. The Nexus Narcolepsy Registry: methodology, study population characteristics, and patterns and predictors of narcolepsy diagnosis. Sleep Med. 2021;84:405–14.

Article  PubMed  Google Scholar 

Morandin M, Bruck D. Understanding automatic behavior in narcolepsy: new insights using a phenomenological approach. Open Sleep J. 2013;6:1–7.

Article  Google Scholar 

Dauvilliers Y, Siegel JM, Lopez R, et al. Cataplexy-clinical aspects, pathophysiology and management strategy. Nat Rev Neurol. 2014;10:386–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Plazzi G, Pizza F, Palaia V, et al. Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain. 2011;134:3477–89.

Article  PubMed  PubMed Central  Google Scholar 

American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien: American Academy of Sleep Medicine; 2014.

Google Scholar 

Bruck D, Costa A. The natural history of health and symptoms in narcolepsy: a 10-year longitudinal study. Aust J Prim Health. 2003;9:59–67.

Article  Google Scholar 

Levy S, McArthur I, Crow B, Zuberi S. Factors influencing time to diagnosis in childhood narcolepsy type 1. J Child Neurol. 2019;34:440–5.

Article  PubMed  Google Scholar 

Wise MS, Lynch J. Narcolepsy in children. Semin Pediatr Neurol. 2001;8:198–206.

Article  CAS  PubMed  Google Scholar 

Szabo ST, Thorpy MJ, Mayer G, et al. Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy. Sleep Med Rev. 2019;43:23–36.

Article  PubMed  Google Scholar 

Peyron C, Faraco J, Rogers W, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000;6:991–7.

Article  CAS  PubMed  Google Scholar 

Thannickal TC, Nienhuis R, Siegel JM. Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. Sleep. 2009;32:993–8.

Article  PubMed  PubMed Central  Google Scholar 

Thannickal TC, Moore RY, Nienhuis R, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron. 2000;27:469–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edition: DSM-5. Washington, DC: American Psychiatric Publishing; 2013.

Book  Google Scholar 

American Academy of Sleep Medicine. International classification of sleep disorders—third edition text revision, summary of diagnostic criteria changes. 3rd-TR ed. Darien: American Academy of Sleep Medicine; 2023.

Google Scholar 

Sutcliffe JG, de Lecea L. The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. J Neurosci Res. 2000;62:161–8.

Article  CAS  PubMed  Google Scholar 

Chieffi S, Carotenuto M, Monda V, et al. Orexin system: the key for a healthy life. Front Physiol. 2017;8:357.

Article  PubMed  PubMed Central  Google Scholar 

Peyron C, Tighe DK, van den Pol AN, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 1998;18:9996–10015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Székely M, Pétervári E, Balaskó M, et al. Effects of orexins on energy balance and thermoregulation. Regul Pept. 2002;104:47–53.

Article  PubMed  Google Scholar 

Harris GC, Wimmer M, Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature. 2005;437:556–9.

Article  CAS  PubMed  Google Scholar 

Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92:573–85.

Article  CAS  PubMed  Google Scholar 

Yamanaka A, Tabuchi S, Tsunematsu T, et al. Orexin directly excites orexin neurons through orexin 2 receptor. J Neurosci. 2010;30:12642–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Acuna-Goycolea C, van den Pol A. Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal. J Neurosci. 2004;24:8141–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X-Y, Chen L, Yang W, Xie A-M. GLP-1 suppresses feeding behaviors and modulates neuronal electrophysiological properties in multiple brain regions. Front Mol Neurosci. 2021;14: 793004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruoff C, Rye D. The ICSD-3 and DSM-5 guidelines for diagnosing narcolepsy: clinical relevance and practicality. Curr Med Res Opin. 2016;32:1611–22.

Article  CAS  PubMed  Google Scholar 

Plazzi G, Clawges HM, Owens JA. Clinical characteristics and burden of illness in pediatric patients with narcolepsy. Pediatr Neurol. 2018;85:21–32.

Article  PubMed  Google Scholar 

Andlauer O, Moore HT, Hong SC, et al. Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Sleep. 2012;35:1247–55.

Article  PubMed  PubMed Central  Google Scholar 

Heier MS, Evsiukova T, Vilming S, et al. CSF hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic CNS hypersomnia in Norway. Sleep. 2007;30:969–73.

Article  PubMed  PubMed Central  Google Scholar 

Thorpy M, Morse AM. Reducing the clinical and socioeconomic burden of narcolepsy by earlier diagnosis and effective treatment. Sleep Med Clin. 2017;12:61–71.

Article  PubMed  Google Scholar 

Dauvilliers Y, Montplaisir J, Molinari N, et al. Age at onset of narcolepsy in two large populations of patients in France and Quebec. Neurology. 2001;57:2029–33.

Article  CAS  PubMed  Google Scholar 

Golden EC, Lipford MC. Narcolepsy: diagnosis and management. Cleve Clin J Med. 2018;85:959–69.

Article  PubMed