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A Post Hoc Analysis of Older Patients with Metastatic Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy Plus Bevacizumab: The Randomized Obelics Study
A Post Hoc Analysis of Older Patients with Metastatic Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy Plus Bevacizumab: The Randomized Obelics Study
Phase II trials and subgroup analyses of clinical studies suggest that bevacizumab plus an oxaliplatin-based chemotherapy ...
Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study
Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study
Polypharmacy is associated with reduced health-related quality of life (HRQoL). This study explores the association betwee...
International Deprescribing Guidelines Did Not Impact Actual Practice in Deprescribing of Potentially Inappropriate Medications for Nursing Home Residents: An Interrupted Time Series Analysis
International Deprescribing Guidelines Did Not Impact Actual Practice in Deprescribing of Potentially Inappropriate Medications for Nursing Home Residents: An Interrupted Time Series Analysis
Deprescribing guidelines reduce the use of potentially inappropriate medications (PIMs) in trial settings; however, their ...
Symptoms of Orthostatic Hypotension and Drugs Affecting Autonomic Function are Associated with the Onset of Frailty in Community-Dwelling Persons Aged 80 Years and Above: A Prospective Observational Study
Symptoms of Orthostatic Hypotension and Drugs Affecting Autonomic Function are Associated with the Onset of Frailty in Community-Dwelling Persons Aged 80 Years and Above: A Prospective Observational Study
Both autonomic dysfunction and frailty are common and complex geriatric syndromes with similar negative health outcomes. B...
Benefit–Risk Assessment of Rivaroxaban in Older Patients With Nonvalvular Atrial Fibrillation or Venous Thromboembolism
Benefit–Risk Assessment of Rivaroxaban in Older Patients With Nonvalvular Atrial Fibrillation or Venous Thromboembolism
Both bleeding and adverse ischemic events increase with age, compounding the benefit–risk balance of anticoagulants ...
Detection of Potential Prescribing Cascades in Multimorbid Older Patients Hospitalised with Acute Illness—An Observational Prospective Prevalence Study
Detection of Potential Prescribing Cascades in Multimorbid Older Patients Hospitalised with Acute Illness—An Observational Prospective Prevalence Study
Prescribing cascades occur when a new drug is prescribed to treat an adverse drug event caused by an existing medication, ...
Management of Late-Onset Rheumatoid Arthritis with Treat-to-Target Strategy
Management of Late-Onset Rheumatoid Arthritis with Treat-to-Target Strategy
The incidence of patients with late-onset rheumatoid arthritis (LORA) is increasing. The clinical diagnosis of LORA is ess...
Comparison of Anticholinergic Burden Scales and Their Association with Cognitive and Functional Impairment in Older Adults: A Cross-Sectional Study Using the REPOSI Database
Comparison of Anticholinergic Burden Scales and Their Association with Cognitive and Functional Impairment in Older Adults: A Cross-Sectional Study Using the REPOSI Database
The increasing use of anticholinergic medications in older adults with multiple chronic conditions raises significant conc...
Treatment Considerations for Severe Osteoporosis in Older Adults
Treatment Considerations for Severe Osteoporosis in Older Adults
Osteoporosis, a chronic metabolic bone disease, increases the predisposition to fragility fractures and is associated with...
The Aging Patient with Cystic Fibrosis
The Aging Patient with Cystic Fibrosis
Cystic fibrosis (CF) is an inherited condition that leads to multiorgan dysfunction, especially in the respiratory, gastro...
Testosterone Therapy in Older Men: Present and Future Considerations
Testosterone Therapy in Older Men: Present and Future Considerations
Testosterone is the classical male anabolic hormone, involved in sexual development, virilisation and regulation of body c...
One-Year Survival and Postoperative Complications in Older Patients with Intertrochanteric Fractures: Association with Polypharmacy—A Multicenter Retrospective Cohort Study
One-Year Survival and Postoperative Complications in Older Patients with Intertrochanteric Fractures: Association with Polypharmacy—A Multicenter Retrospective Cohort Study
Polypharmacy is common in older patients and associated with adverse outcomes. However, the association with outcomes in p...
Risk Factors for Vancomycin-Induced Nephrotoxicity and Kidney Prognosis in Patients Aged 75 Years and Older: A Retrospective Study
Risk Factors for Vancomycin-Induced Nephrotoxicity and Kidney Prognosis in Patients Aged 75 Years and Older: A Retrospective Study
Whether risk factors for vancomycin-induced nephrotoxicity (VIN) development reported in recent years are also risk factor...
Combination Pharmacotherapy for Benign Prostatic Hyperplasia: Evaluation of Existing Literature on Combination Therapies for Lower Urinary Tract Symptoms Associated with BPH
Combination Pharmacotherapy for Benign Prostatic Hyperplasia: Evaluation of Existing Literature on Combination Therapies for Lower Urinary Tract Symptoms Associated with BPH
Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) significantly impact quality of lif...
Age Does not Affect the Efficacy of Antibody Drug Conjugates, But is Associated with High-Grade Adverse Events in Patients with Cancer Enrolled in Early Phase Clinical Trials
Age Does not Affect the Efficacy of Antibody Drug Conjugates, But is Associated with High-Grade Adverse Events in Patients with Cancer Enrolled in Early Phase Clinical Trials
Data on the use of antibody drug conjugates (ADCs) in older patients are scarce. The objective was to study the safety and...
Managing Rheumatoid Arthritis in Older Adults with Cancer
Managing Rheumatoid Arthritis in Older Adults with Cancer
Rheumatoid arthritis (RA) is a chronic autoimmune condition disproportionately affecting older adults (> 60 years),...
Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options
Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options
Illustration of intravesical drug delivery via a transurethral catheter in female mice. Combined instillation of paramagne...
Prospective Monitoring of New Drugs in Older Adults with and without Frailty: Near-Real-Time Assessment of Effectiveness and Safety of Oral Anticoagulants in Medicare Data
Prospective Monitoring of New Drugs in Older Adults with and without Frailty: Near-Real-Time Assessment of Effectiveness and Safety of Oral Anticoagulants in Medicare Data
Prospective sequential analyses after a new drug approval allow proactive surveillance of new drugs. In the current study,...
Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials
Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials
Insomnia is more common as people age. Several common hypnotics used to treat insomnia often do not adequately alleviate s...
Fall Outcomes in Older Adults Following Benzodiazepine/Z-Drug Discontinuation: A Retrospective Cohort Study in an Academic Health System
Fall Outcomes in Older Adults Following Benzodiazepine/Z-Drug Discontinuation: A Retrospective Cohort Study in an Academic Health System
Benzodiazepines and z-drugs increase the fall risk in older adults. There is a lack of real-world data examining the assoc...
Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia
Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia
Older inpatients with dementia are at an increased risk of an adverse drug reaction (ADR) during hospitalization. To quant...
Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects
Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects
Corticosteroids play a crucial role as anti-inflammatory and immunomodulatory agents in dermatology and other medical spec...
Co-Designing a Consult Patient Decision Aid for Continuation Versus Deprescribing Cholinesterase Inhibitors in People Living with Dementia
Co-Designing a Consult Patient Decision Aid for Continuation Versus Deprescribing Cholinesterase Inhibitors in People Living with Dementia
As dementia progresses, people living with dementia may take high-risk, unnecessary, or ineffective medicines. Cholinester...
The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia
The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia
Antipsychotics and cognitive enhancers are often used to treat psychosis and behavioral disturbances in individuals with d...
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults
Approximately one in three older adults (aged 65 years and over) experience pain, negatively impacting their quality of li...
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects
Presbyopia is a common age-related visual impairment. With the aging of the population, the incidence of presbyopia is inc...
Pharmacological Treatment of Obesity in Older Adults
Pharmacological Treatment of Obesity in Older Adults
Obesity is a complex health issue with growing prevalence worldwide. It is also becoming more prevalent in the population ...
Assessing Long-Term Adverse Outcomes in Older Kidney Transplant Recipients: A Propensity Score-Matched Comparison of Early Steroid Withdrawal Versus Continuous Steroid Immunosuppression Using a Large Real-World Database
Assessing Long-Term Adverse Outcomes in Older Kidney Transplant Recipients: A Propensity Score-Matched Comparison of Early Steroid Withdrawal Versus Continuous Steroid Immunosuppression Using a Large Real-World Database
Steroids are widely used in maintenance immunosuppression treatment in kidney transplant recipients. Older individuals und...
Development of a Frailty Screening Tool Using Electronic Community Pharmacy Records
Development of a Frailty Screening Tool Using Electronic Community Pharmacy Records
Frailty is associated with increased susceptibility to medication-related harm, highlighting the importance of medication ...
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
Cenobamate is an antiseizure medication (ASM) approved in the US and Europe for the treatment of uncontrolled focal seizur...
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