Handelsman DJ, et al. Androgen physiology, pharmacology, use and misuse. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext. South Dartmouth: MDText.com, Inc.; 2020. p. 5.
Yeap BB, Grossmann M, McLachlan RI, et al. Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy. Med J Aust. 2016;205:173–8.
Yeap BB, Grossmann M, McLachlan RI, et al. Endocrine Society of Australia position statement on male hypogonadism (part 2): treatment and therapeutic considerations. Med J Aust. 2016;205:228–31.
Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with hypogonadism: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103:1715–44.
De Silva NL, Papanikolaou N, Grossmann M, et al. Male hypogonadism: pathogenesis, diagnosis, and management. Lancet Diabetes Endocrinol. 2024;12:761–74.
Sikaris K, McLachlan RI, Kazlauskas R, de Kretser D, Holden CA, Handelsman DJ. Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays. J Clin Endocrinol Metab. 2005;90:5928–36.
Article CAS PubMed Google Scholar
Yeap BB, Alfonso H, Chubb SA, et al. Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men. J Clin Endocrinol Metab. 2012;97:4030–9.
Article CAS PubMed Google Scholar
Shi Z, Araujo AB, Martin S, O’Loughlin P, Wittert GA. Longitudinal changes in testosterone over five years in community-dwelling men. J Clin Endocrinol Metab. 2013;98:3289–97.
Article CAS PubMed Google Scholar
Camacho EM, Huhtaniemi IT, O’Neill TW, et al. Age-associated changes hypothalamic-pituitary-testicular function in middle-aged and older men modified by weight changes and lifestyle factors: longitudinal results from European Male Ageing Study. Eur J Endocrinol. 2013;168:445–55.
Article CAS PubMed Google Scholar
Marriott RJ, Murray K, Adams RJ, et al. Factors associated with circulating sex hormones in men: individual participant data meta-analyses. Ann Intern Med. 2023;176:1221–34.
Article PubMed PubMed Central Google Scholar
Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab. 2001;86:724–31.
Article CAS PubMed Google Scholar
Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 2002;87:589–98.
Article CAS PubMed Google Scholar
Handelsman DJ, Yeap BB, Flicker L, Martin S, Wittert GA, Ly LP. Age-specific population centiles for androgen status in men. Eur J Endocrinol. 2015;173:809–17.
Article CAS PubMed Google Scholar
Yeap BB, Manning L, Chubb SAP, et al. Progressive impairment of testicular endocrine function in ageing men: testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life. Clin Endocrinol (Oxf). 2018;88:88–95.
Article CAS PubMed Google Scholar
Cohen J, Nassau DE, Patel P, et al. Low testosterone in adolescents and young adults. Front Endocrinol. 2020;10:916.
Hodges-Simeon CR, Grail GPO, Albert G, et al. Testosterone therapy masculinizes speech and gender presentation in transgender men. Sci Rep. 2021;11:3494.
Article CAS PubMed PubMed Central Google Scholar
Wu FCW, Tajar A, Beynon JM, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med. 2010;363:123–35.
Article CAS PubMed Google Scholar
Travison TG, Vesper HW, Orwoll E, et al. Harmonized reference ranges for circulating testosterone levels in men of four cohort studies in the United States and Europe. J Clin Endocrinol Metab. 2017;102:1161–73.
Article PubMed PubMed Central Google Scholar
Handelsman DJ. Free testosterone: pumping up the tires or ending the free ride? Endocr Rev. 2017;38:297–301.
Nyamaah JA, Narinx N, Antonio L, Vanderschueren D. Use of calculated free testosterone in men: advantages and limitations. Curr Opin Endocrinol Diabetes Obes. 2024;31:230–5.
Article CAS PubMed Google Scholar
Jasuja R, Pencina KM, Spencer DJ, et al. Reference intervals for free testosterone in adult men measured using a standardized equilibrium dialysis procedure. Andrology. 2023;11:125–33.
Article CAS PubMed Google Scholar
Ly LP, Sartorius G, Hull L, et al. Accuracy of calculated free testosterone formulae in men. Clin Endocrinol (Oxf). 2010;73:382–8.
Article CAS PubMed Google Scholar
Yeap BB, Wu FCW. Clinical practice update on testosterone therapy for male hypogonadism: contrasting perspectives to optimise care. Clin Endocrinol (Oxf). 2019;90:56–65.
Article CAS PubMed Google Scholar
Goldman AL, Bhasin S, Wu FCW, Krishna M, Matsumoto AM, Jasuja R. A reappraisal of testosterone’s binding in circulation: physiological and clinical implications. Endocr Rev. 2017;38:302–24.
Article PubMed PubMed Central Google Scholar
Narinx N, Marriott RJ, Murray K, et al. Sociodemographic, lifestyle and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses. Eur J Endocrinol. 2024;191:523–34.
Yeap BB, Marriott RJ, Antonio L, et al. Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone-binding globulin in men from UK Biobank. Clin Endocrinol (Oxf). 2021;94:290–302.
Article CAS PubMed Google Scholar
Grossmann M. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab. 2011;96:2341–53.
Article CAS PubMed Google Scholar
Grossmann M. Indications for testosterone therapy in men. Curr Opin Endocrinol Diabetes Obes. 2024;31:249–56.
Article CAS PubMed Google Scholar
Yeap BB, Tran C, Douglass CM, McNeil JJ. Beyond T-Trials, T4DM and TRAVERSE: the next large testosterone randomized controlled trial. Curr Opin Endocrinol Diabetes Obes. 2024;31:222–9.
Article CAS PubMed Google Scholar
Snyder PJ, Bhasin S, Cunningham GR, et al. Effects of testosterone treatment in older men. N Engl J Med. 2016;374:611–24.
Article CAS PubMed PubMed Central Google Scholar
Snyder PJ, Bhasin S, Cunningham GR, et al. Lessons from the testosterone trials. Endocr Rev. 2018;39:369–86.
Article PubMed PubMed Central Google Scholar
Wittert G, Atlantis E, Allan C, et al. Testosterone therapy to prevent type 2 diabetes mellitus in at-risk men (T4DM): design and implementation of a double-blind randomised controlled trial. Diabetes Obes Metab. 2019;21:772–80.
Article CAS PubMed Google Scholar
Wittert G, Bracken K, Robledo KP, et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle program (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. Lancet Diabetes Endocrinol. 2021;9:32–45.
Comments (0)