Treatment Considerations for Severe Osteoporosis in Older Adults

United Nations. World social report 2023: Leaving no one behind in an ageing World [Internet]. United Nations, Department of Economic and Social Affairs Population Division; 2023. https://www.un.org/development/desa/dspd/wp-content/uploads/sites/22/2023/01/WSR_2023_Chapter_Key_Messages.pdf [Internet]. Accessed 4 Oct 2023.

World Health Organisation. Ageing and health [Internet]. World Health Organisation; 2022. https://www.who.int/news-room/fact-sheets/detail/ageing-and-health [Internet]. Accessed 4 Oct 2023.

World Health Organisation. Ghe: Life expectancy and healthy life expectancy [Internet]. World Health Organisation; 2020. https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-life-expectancy-and-healthy-life-expectancy [Internet]. Accessed 3 Oct 2023.

International population reports—census.gov [Internet]. United States Census Bureau; 2016. https://www.census.gov/content/dam/Census/library/publications/2016/demo/p95-16-1.pdf [Internet]. Accessed 4 Oct 2023.

United Nations. World population prospects 2022: Summary of results | population division [Internet]. United Nations, Department of Economic and Social Affairs Population Division; 2022. https://www.un.org/development/desa/pd/content/World-Population-Prospects-2022 [Internet]. Accessed 4 Oct 2023.

Briggs AM, Cross MJ, Hoy DG, Sànchez-Riera L, Blyth FM, Woolf AD, March L. Musculoskeletal health conditions represent a global threat to healthy aging: a report for the 2015 World Health Organization World Report on Ageing and Health. Gerontologist. 2016;56(Suppl 2):S243-255. https://doi.org/10.1093/geront/gnw002.

Article  PubMed  Google Scholar 

Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, Vos T. Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2021;396(10267):2006–17. https://doi.org/10.1016/s0140-6736(20)32340-0.

Article  CAS  PubMed  Google Scholar 

GOV UK. Musculoskeletal health: Applying all our health [Internet]. Office for Health Improvement & Disparities. 2022. https://www.gov.uk/government/publications/musculoskeletal-health-applying-all-our-health/musculoskeletal-health-applying-all-our-health#:~:text=MSK%20conditions%20account%20for%20the,%C2%A35%20billion%20each%20year.&text=The%20pain%20and%20disability%20of,family%2C%20social%20and%20working%20life. Accessed 10 Feb 2025.

Why are musculoskeletal conditions the biggest contributor to morbidity? [Internet]. Public Health England; 2019. https://ukhsa.blog.gov.uk/2019/03/11/why-are-musculoskeletal-conditions-the-biggest-contributor-to-morbidity/. Accessed 10 Feb 2025.

Compston J, Cooper A, Cooper C, Gittoes N, Gregson C, Harvey N, Hope S, Kanis JA, McCloskey EV, Poole KES, et al. UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos. 2017;12(1):43. https://doi.org/10.1007/s11657-017-0324-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sözen T, Özışık L, Başaran N. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4(1):46–56. https://doi.org/10.5152/eurjrheum.2016.048.

Article  PubMed  Google Scholar 

Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17(12):1726–33. https://doi.org/10.1007/s00198-006-0172-4.

Article  CAS  PubMed  Google Scholar 

Liu J, Curtis EM, Cooper C, Harvey NC. State of the art in osteoporosis risk assessment and treatment. J Endocrinol Investig. 2019;42(10):1149–64. https://doi.org/10.1007/s40618-019-01041-6.

Article  CAS  Google Scholar 

Willers C, Norton N, Harvey NC, Jacobson T, Johansson H, Lorentzon M, McCloskey EV, Borgström F, Kanis JA. Osteoporosis in Europe: a compendium of country-specific reports. Arch Osteoporos. 2022;17(1):23. https://doi.org/10.1007/s11657-021-00969-8.

Article  PubMed  PubMed Central  Google Scholar 

Hawley S, Javaid MK, Prieto-Alhambra D, Lippett J, Sheard S, Arden NK, Cooper C, Judge A. Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: population-based longitudinal study. Age Ageing. 2016;45(2):236–42. https://doi.org/10.1093/ageing/afv204.

Article  PubMed  PubMed Central  Google Scholar 

Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrol. 2008;3(Suppl 3):S131-139. https://doi.org/10.2215/CJN.04151206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oftadeh R, Perez-Viloria M, Villa-Camacho JC, Vaziri A, Nazarian A. Biomechanics and mechanobiology of trabecular bone: a review. J Biomech Eng. 2015. https://doi.org/10.1115/1.4029176.

Article  PubMed  PubMed Central  Google Scholar 

Olsen BR, Reginato AM, Wang W. Bone development. Annu Rev Cell Dev Biol. 2000;16:191–220. https://doi.org/10.1146/annurev.cellbio.16.1.191.

Article  CAS  PubMed  Google Scholar 

Katsimbri P. The biology of normal bone remodelling. Eur J Cancer Care (Engl). 2017. https://doi.org/10.1111/ecc.12740.

Article  PubMed  Google Scholar 

Delitala AP, Scuteri A, Doria C. Thyroid hormone diseases and osteoporosis. J Clin Med. 2020. https://doi.org/10.3390/jcm9041034.

Article  PubMed  PubMed Central  Google Scholar 

Alswat KA. Gender disparities in osteoporosis. J Clin Med Res. 2017;9(5):382–7. https://doi.org/10.14740/jocmr2970w.

Article  PubMed  PubMed Central  Google Scholar 

Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem. 2010;285(33):25103–8. https://doi.org/10.1074/jbc.R109.041087.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siddiqui JA, Partridge NC. Physiological bone remodeling: systemic regulation and growth factor involvement. Physiology (Bethesda). 2016;31(3):233–45. https://doi.org/10.1152/physiol.00061.2014.

Article  CAS  PubMed  Google Scholar 

Sfeir JG, Drake MT, Khosla S, Farr JN. Skeletal aging. Mayo Clin Proc. 2022;97(6):1194–208. https://doi.org/10.1016/j.mayocp.2022.03.011.

Article  CAS  PubMed  Google Scholar 

Zanker J, Duque G. Osteoporosis in older persons: old and new players. J Am Geriatr Soc. 2019;67(4):831–40. https://doi.org/10.1111/jgs.15716.

Article  PubMed  Google Scholar 

Demontiero O, Vidal C, Duque G. Aging and bone loss: new insights for the clinician. Ther Adv Musculoskelet Dis. 2012;4(2):61–76. https://doi.org/10.1177/1759720x11430858.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fragility Fractures [Internet]. IOF. 2025. https://www.osteoporosis.foundation/health-professionals/fragility-fractures/assessing-vertebral-fractures. Accessed 10 Feb 2025.

Nuti R, Brandi ML, Isaia G, Tarantino U, Silvestri S, Adami S. New perspectives on the definition and the management of severe osteoporosis: the patient with two or more fragility fractures. J Endocrinol Investig. 2009;32(9):783–8. https://doi.org/10.1007/bf03346537.

Article  CAS  Google Scholar 

Kanis JA, Cooper C, Rizzoli R, Reginster JY. Executive summary of European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Aging Clin Exp Res. 2019;31(1):15–7. https://doi.org/10.1007/s40520-018-1109-4.

Article  CAS  PubMed  Google Scholar 

Kanis JA, Harvey NC, Johansson H, Liu E, Vandenput L, Lorentzon M, Leslie WD, McCloskey EV. A decade of FRAX: how has it changed the management of osteoporosis? Aging Clin Exp Res. 2020;32(2):187–96. https://doi.org/10.1007/s40520-019-01432-y.

Article  PubMed  Google Scholar 

Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2013;24(1):23–57. https://doi.org/10.1007/s00198-012-2074-y.

Article  CAS  PubMed  Google Scholar 

McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, Barkmann R, Boutroy S, Brown J, Chapurlat R, et al. A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX. J Bone Miner Res. 2016;31(5):940–8. https://doi.org/10.1002/jbmr.2734.

Article  PubMed  Google Scholar 

Kanis JA, Harvey NC, Johansson H, Odén A, McCloskey EV, Leslie WD. Overview of fracture prediction tools. J Clin Densitom. 2017;20(3):444–50. https://doi.org/10.1016/j.jocd.2017.06.013.

Article  PubMed  PubMed Central  Google Scholar 

Shepherd J, Gurney S, Patel HP. Shared decision making and personalised care support planning: pillars of integrated care for older people. Clin Integr Care. 2022;12: 100097. https://doi.org/10.1016/j.intcar.2022.100097.

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