Di Matteo A, Bathon JM, Emery P. Rheumatoid arthritis. Lancet. 2023;402(10416):2019–33.

Article  PubMed  Google Scholar 

Yamanaka H, Tanaka E, Nakajima A, et al. A large observational cohort study of rheumatoid arthritis, IORRA: providing context for today’s treatment options. Mod Rheumatol. 2020;30(1):1–6.

Article  PubMed  Google Scholar 

Fujii T, Murata K, Onizawa H, et al. Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort. Arthritis Res Ther. 2024;26(1):16.

Article  PubMed  PubMed Central  Google Scholar 

Yamada H, Jinno S, Maeda T, et al. Trends of disease activity in Japanese patients over 75 years with rheumatoid arthritis from 2014 to 2021: the ANSWER cohort study. Rheumatology (Oxford). 2024;63(8):2147–51.

Article  PubMed  Google Scholar 

Smolen JS, Aletaha D, Bijlsma JW, et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2010;69(4):631–7.

Article  PubMed  Google Scholar 

Smolen JS, Breedveld FC, Burmester GR, et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis. 2016;75(1):3–15.

Article  PubMed  Google Scholar 

Nakayama Y, Nagata W, Takeuchi Y, et al. Systematic review and meta-analysis for the 2024 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis. Mod Rheumatol. 2024;34(6):1079–94.

Article  PubMed  Google Scholar 

He J, Wang Y, Liu Q, Li R. Theory and practice of treat-to-target (T2T) in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2025;39(1):102018.

Messelink MA, den Broeder AA, Marinelli FE, et al. What is the best target in a treat-to-target strategy in rheumatoid arthritis? Results from a systematic review and meta-regression analysis. RMD Open. 2023;9(2):e003196. https://doi.org/10.1136/rmdopen-2023-003196.

Article  PubMed  PubMed Central  Google Scholar 

Sugano E, Tanaka E, Inoue E, et al. Differences in patients’ population and efficacy/effectiveness of biologic disease-modifying antirheumatic drugs between randomized controlled trials and real-world settings in patients with rheumatoid arthritis—using the IORRA cohort. Mod Rheumatol. 2022;32(4):675–85.

Cabinet_Office. 2024 annual report on the ageing society. In: Annual report on the ageing society. 2024. https://www8.cao.go.jp/kourei/whitepaper/w-2024/zenbun/06pdf_index.html. Accessed 11 Feb 2025.

Beard JR, Officer A, de Carvalho IA, et al. The World report on ageing and health: a policy framework for healthy ageing. Lancet. 2016;387(10033):2145–54.

Article  PubMed  Google Scholar 

Sugihara T, Harigai M. Targeting low disease activity in elderly-onset rheumatoid arthritis: current and future roles of biological disease-modifying antirheumatic drugs. Drugs Aging. 2016;33(2):97–107.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pavlov-Dolijanovic S, Bogojevic M, Nozica-Radulovic T, Radunovic G, Mujovic N. Elderly-onset rheumatoid arthritis: characteristics and treatment options. Medicina (Kaunas). 2023;59(10):1878. https://doi.org/10.3390/medicina59101878.

Article  PubMed  Google Scholar 

Serhal L, Lwin MN, Holroyd C, Edwards CJ. Rheumatoid arthritis in the elderly: characteristics and treatment considerations. Autoimmun Rev. 2020;19(6): 102528.

Article  PubMed  Google Scholar 

Matsui T, Yoshida T, Nishino T, Yoshizawa S, Sawada T, Tohma S. Trends in treatment for patients with late-onset rheumatoid arthritis in Japan: data from the NinJa study. Mod Rheumatol. 2024;34(5):881–91.

Sugihara T, Ishizaki T, Hosoya T, et al. Structural and functional outcomes of a therapeutic strategy targeting low disease activity in patients with elderly-onset rheumatoid arthritis: a prospective cohort study (CRANE). Rheumatology (Oxford). 2015;54(5):798–807.

Article  CAS  PubMed  Google Scholar 

Sugihara T, Ishizaki T, Onoguchi W, et al. Effectiveness and safety of treat-to-target strategy in elderly-onset rheumatoid arthritis: a 3-year prospective observational study. Rheumatology (Oxford). 2021;60(9):4252–61.

Article  CAS  PubMed  Google Scholar 

Jinno S, Onishi A, Hattori S, et al. Comparison of retention of biologics in Japanese patients with elderly-onset rheumatoid arthritis—the ANSWER cohort study. Rheumatology (Oxford). 2025;64(2):509–16.

Lee J, Martindale J, Makris UE, Singh N, Yung R, Bynum JPW. Initiation of disease-modifying antirheumatic drugs in older medicare beneficiaries with new diagnosis of late-onset rheumatoid arthritis. ACR Open Rheumatol. 2023;5(12):694–700.

Article  PubMed  PubMed Central  Google Scholar 

Nilsson J, Andersson MLE, Hafstrom I, et al. Influence of age and sex on disease course and treatment in rheumatoid arthritis. Open Access Rheumatol. 2021;13:123–38.

Article  PubMed  PubMed Central  Google Scholar 

Schoels M, Knevel R, Aletaha D, et al. Evidence for treating rheumatoid arthritis to target: results of a systematic literature search. Ann Rheum Dis. 2010;69(4):638–43.

Article  PubMed  Google Scholar 

Stoffer MA, Schoels MM, Smolen JS, et al. Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update. Ann Rheum Dis. 2016;75(1):16–22.

Article  PubMed  Google Scholar 

Smolen JS, Landewe RBM, Bergstra SA, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. Ann Rheum Dis. 2023;82(1):3–18.

Article  CAS  PubMed  Google Scholar 

Fraenkel L, Bathon JM, England BR, et al. 2021 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2021;73(7):924–39.

Article  PubMed  PubMed Central  Google Scholar 

Harigai M, Kaneko Y, Tanaka E, et al. 2024 Update of Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis—secondary publication. Mod Rheumatol. 2025;roaf006. https://doi.org/10.1093/mr/roaf006. Epub ahead of print.

Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569–81.

Article  PubMed  Google Scholar 

Takanashi S, Kaneko Y, Kawahito Y, et al. A preliminary survey of rheumatologists on the management of late-onset rheumatoid arthritis in Japan. Intern Med. 2024;63(24):3299–306.

Ouchi Y, Rakugi H, Arai H, et al. Redefining the elderly as aged 75 years and older: proposal from the Joint Committee of Japan Gerontological Society and the Japan Geriatrics Society. Geriatr Gerontol Int. 2017;17(7):1045–7.

Article  PubMed  Google Scholar 

Sugihara T. Treatment strategies for elderly-onset rheumatoid arthritis in the new era. Mod Rheumatol. 2022;32(3):493–9.

Article  PubMed  Google Scholar 

Romao VC, Humby F, Kelly S, et al. Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study. Semin Arthritis Rheum. 2020;50(4):735–43.

Article  PubMed  Google Scholar 

Shimizu M, Paudel ML, Shadick N, Weinblatt M, Solomon DH. Age of onset of rheumatoid arthritis and radiographic changes. Semin Arthritis Rheum. 2025;71: 152635.

Article  PubMed  Google Scholar 

Sugitani N, Tanaka E, Inoue E, et al. Higher risk of poor functional outcome and unfavorable clinical events for late-onset rheumatoid arthritis: results from the IORRA cohort. Rheumatology (Oxford). 2024;keae673. https://doi.org/10.1093/rheumatology/keae673. Epub ahead of print.

Uchiyama S, Takanashi S, Takeno M, et al. Should we reconsider the definition of elderly-onset rheumatoid arthritis in an ageing society? Mod Rheumatol. 2022;32(2):323–9.

Article  PubMed  Google Scholar 

Matsumoto T, Sugihara T, Hosoya T, et al. Effectiveness and safety of treat-to-target strategy for methotrexate-naive rheumatoid arthritis patients > 75 years of age. Rheumatol Adv Pract. 2024;8(1):rkae019.

Article  PubMed  PubMed Central  Google Scholar 

Li X, Cesta A, Movahedi M, Bombardier C. Late-onset rheumatoid arthritis has a similar time to remission as younger-onset rheumatoid arthritis: results from the Ontario Best Practices Research Initiative. Arthritis Res Ther. 2022;24(1):255.

Article  PubMed  PubMed Central  Google Scholar 

Kojima M, Sugihara T, Kawahito Y, et al. Consensus statement on the management of late-onset rheumatoid arthritis. Mod Rheumatol. 2024;34(6):1095–102.

Article  PubMed  Google Scholar 

Kim DH, Rockwood K. Frailty in older adults. N Engl J Med. 2024;391(6):538–48.

Article  PubMed  PubMed Central  Google Scholar 

Yamada M, Arai H. Predictive value of frailty scores for healthy life expectancy in community-dwelling older Japanese adults. J Am Med Dir Assoc. 2015;16(11):1002 e7-1002 e11.

Article  PubMed