Vermeiren S, Vella-Azzopardi R, Beckwee D, Habbig AK, Scafoglieri A, Jansen B, et al. Frailty and the prediction of negative health outcomes: a meta-analysis. J Am Med Dir Assoc. 2016;17(12):116e31–1163e17.
Ofori-Asenso R, Chin KL, Mazidi M, Zomer E, Ilomaki J, Zullo AR, et al. Global incidence of frailty and prefrailty among community-dwelling older adults: a systematic review and meta-analysis. JAMA Netw Open. 2019;2(8):e198398.
Article PubMed PubMed Central Google Scholar
Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston JD. Management of frailty: opportunities, challenges, and future directions. Lancet. 2019;394(10206):1376–86.
Kolle AT, Lewis KB, Lalonde M, Backman C. Reversing frailty in older adults: a scoping review. BMC Geriatr. 2023;23(1):751.
Article PubMed PubMed Central Google Scholar
Wehrwein EA, Orer HS, Barman SM. Overview of the anatomy, physiology, and pharmacology of the autonomic nervous system. Compr Physiol. 2016;6(3):1239–78.
Klein CM. Evaluation and management of autonomic nervous system disorders. Semin Neurol. 2008;28(2):195–204.
Thornton K, Mitchell MO. Autonomic dysfunction: a guide for FPs. J Fam Pract. 2017;66(9):539–43.
Zygmunt A, Stanczyk J. Methods of evaluation of autonomic nervous system function. Arch Med Sci. 2010;6(1):11–8.
Article PubMed PubMed Central Google Scholar
Fedorowski A, Ricci F, Hamrefors V, Sandau KE, Hwan Chung T, Muldowney JAS, et al. Orthostatic hypotension: management of a complex, but common, medical problem. Circ Arrhythm Electrophysiol. 2022;15(3):e010573.
Article PubMed PubMed Central Google Scholar
Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21(2):69–72.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias NJ. Dysautonomia: a forgotten condition - part 1. Arq Bras Cardiol. 2021;116(4):814–35.
Article CAS PubMed PubMed Central Google Scholar
Christopoulos EM, Tran J, Hillebrand SL, Lange PW, Iseli RK, Meskers CGM, et al. Initial orthostatic hypotension and orthostatic intolerance symptom prevalence in older adults: a systematic review. Int J Cardiol Hypertens. 2021;8:100071.
Shaw BH, Borrel D, Sabbaghan K, Kum C, Yang Y, Robinovitch SN, et al. Relationships between orthostatic hypotension, frailty, falling and mortality in elderly care home residents. BMC Geriatr. 2019;19(1):80.
Article PubMed PubMed Central Google Scholar
Debain A, Loosveldt FA, Knoop V, Costenoble A, Lieten S, Petrovic M, et al. Frail older adults are more likely to have autonomic dysfunction: a systematic review and meta-analysis. Ageing Res Rev. 2023;87:101925.
Article CAS PubMed Google Scholar
O’Connell MD, Savva GM, Fan CW, Kenny RA. Orthostatic hypotension, orthostatic intolerance and frailty: the Irish longitudinal study on aging-TILDA. Arch Gerontol Geriatr. 2015;60(3):507–13.
Fried LP, Cohen AA, Xue QL, Walston J, Bandeen-Roche K, Varadhan R. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nat Aging. 2021;1(1):36–46.
Article PubMed PubMed Central Google Scholar
Zeidan RS, McElroy T, Rathor L, Martenson MS, Lin Y, Mankowski RT. Sex differences in frailty among older adults. Exp Gerontol. 2023;184:112333.
de Oliveira DC, Maximo RO, Ramirez PC, de Souza AF, Luiz MM, Delinocente MLB, et al. Does the incidence of frailty differ between men and women over time? Arch Gerontol Geriatr. 2023;106:104880.
Lu YW, Chang CC, Chou RH, Lee WJ, Chen LK, Huang PH, et al. Sex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort. BMC Geriatr. 2024;24(1):182.
Article PubMed PubMed Central Google Scholar
Mielke N, Schneider A, Huscher D, Ebert N, Schaeffner E. Gender differences in frailty transition and its prediction in community-dwelling old adults. Sci Rep. 2022;12(1):7341.
Article CAS PubMed PubMed Central Google Scholar
Costenoble A, Knoop V, Debain A, Vermeiren S, Vella Azzopardi R, Rossi G, et al. Prefrailty: the relationship between daily activities and social participation in older persons. J Appl Gerontol. 2022;41(2):430–40.
Knoop V, Costenoble A, Debain A, Bravenboer B, Jansen B, Scafoglieri A, et al. Muscle endurance and self-perceived fatigue predict decline in gait speed and activities of daily living after 1-year follow-up: results from the BUTTERFLY study. J Gerontol A Biol Sci Med Sci. 2023;78(8):1402–9.
Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, et al. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ study. Mech Ageing Dev. 2012;133(6):456–66.
Article CAS PubMed Google Scholar
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.
Article CAS PubMed Google Scholar
Steverink N, Slaets J, Schuurmans H, Lis M. Measuring frailty: developing and testing the GFI (Groningen Frailty Indicator). Gerontologist. 2001;41:236–7.
Knoop V, Costenoble A, Debain A, Vella Azzopardi R, Vermeiren S, van Laere S, et al. The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians. Exp Gerontol. 2021;152:111440.
Article CAS PubMed Google Scholar
Sirola J, Pitkala KH, Tilvis RS, Miettinen TA, Strandberg TE. Definition of frailty in older men according to questionnaire data (RAND-36/SF-36): the Helsinki businessmen study. J Nutr Health Aging. 2011;15(9):783–7.
Article CAS PubMed Google Scholar
Knoop V, Costenoble A, Debain A, Van der Meulen K, De Vriendt P, Gorus E, et al. Impact of COVID-19 on physical activity, fatigue, and frailty in community-dwelling older adults: a cross-sectional study. J Aging Phys Act. 2023;32(2):172–84.
Bolina AF, Gomes NC, Marchiori GF, Pegorari MS, Tavares D. Potentially inappropriate medication use and frailty phenotype among community-dwelling older adults: a population-based study. J Clin Nurs. 2019;28(21–22):3914–22.
Lim R, Kalisch Ellett LM, Widagdo IS, Pratt NL, Roughead EE. Analysis of anticholinergic and sedative medicine effects on physical function, cognitive function, appetite and frailty: a cross-sectional study in Australia. BMJ Open. 2019;9(9):e029221.
Article PubMed PubMed Central Google Scholar
Mahmood SS, Levy D, Vasan RS, Wang TJ. The Framingham heart study and the epidemiology of cardiovascular disease: a historical perspective. Lancet. 2014;383(9921):999–1008.
Dani M, Dirksen A, Taraborrelli P, Panagopolous D, Torocastro M, Sutton R, et al. Orthostatic hypotension in older people: considerations, diagnosis and management. Clin Med (Lond). 2021;21(3):e275–82.
Frith J, Newton JL. Validation of a questionnaire for orthostatic hypotension for routine clinical use. Geriatr Gerontol Int. 2016;16(7):785–90.
Comments (0)