Age Does not Affect the Efficacy of Antibody Drug Conjugates, But is Associated with High-Grade Adverse Events in Patients with Cancer Enrolled in Early Phase Clinical Trials

Funding

No external funding was used in the preparation of this manuscript.

Conflict of interest

Maxime Frélaut reports a fee for participation in Advisory Board from Sandoz, the receipt of a fee as an invited speaker from MSD, and the receipt of a research grant to institution from IPSEN. Capucine Baldini has served a consulting or advisory role for: Rising Tide Foundation, Bicycle Therapeutics, and Janssen Oncology; Capucine Baldini has received research funding from Foundation BMS (Inst) and has given expert testimony for: Bristol Myers Squibb, AbbVie, MSD Oncology, and AstraZeneca. In addition, Capucine Baldini has received funds for travel, accommodations, and expenses from: Roche/Genentech, Amgen, MSD Oncology, and Janssen Oncology. Ana Vaz Ferreira, Matthieu Delaye, Arnaud Pages, Antoine Hollebecque, Anas Gazzah, Rastio Bahleda, Jean-Marie Michot, Francois-Xavier Danlos, Lauren Seknazi, Vincent Goldschmidt, Clémence Hénon, Madonna Sakkal, Cristina Smolenschi, Stéphane Champiat, Aurelien Marabelle, Yohann Loriot, Céline Nagera Lazarovici, Zoé Ap-Thomas, Geoffroy Beraud Chaullet, Santiago Ponce Aix, Christophe Massard, and Kaissa Ouali declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.

Ethics approval and consent to participate

All patients included in this analysis have given their consent for inclusion in the clinical trials and subsequent use of the trial data.

Consent to publish

Not applicable.

Data availability statement

Raw data are not publicly available to preserve individuals’ privacy under the European General Data Protection Regulation.

Code availability

Not applicable.

Author contributions

Ana Vaz Ferreira and Matthieu Delaye carried out data collection and wrote the first draft of the manuscript. Arnaud Pages carried out statistical analysis and manuscript proofreading. Antoine Hollebecque carried out manuscript proofreading. Anas Gazzah carried out manuscript proofreading. Rastio Bahleda carried out manuscript proofreading. Jean-Marie Michot carried out manuscript proofreading. Francois-Xavier Danlos carried out manuscript proofreading. Lauren Seknazi carried out manuscript proofreading. Vincent Goldschmidt carried out manuscript proofreading. Clémence Hénon carried out manuscript proofreading. Madonna Sakkal carried out manuscript proofreading. Cristina Smolenschi carried out manuscript proofreading. Stéphane Champiat carried out manuscript proofreading. Aurelien Marabelle carried out manuscript proofreading. Yohann Loriot carried out manuscript proofreading. Céline Nagera Lazarovici carried out manuscript proofreading. Zoé Ap-Thomas carried out manuscript proofreading. Geoffroy Beraud Chaullet carried out manuscript proofreading. Santiago Ponce Aix carried out manuscript proofreading. Christophe Massard carried out manuscript proofreading and supervision. Kaissa Ouali carried out manuscript proofreading. Maxime Frelaut carried out supervision and manuscript proofreading. Capucine Baldini carried out supervision and manuscript proofreading.

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