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RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch
RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch
Hyperinflammatory response in early stage of sepsis was the key factor leading to multi-organ injury. Therefore, exploring...
Plasma surrogate markers of neutrophil extracellular traps correlate with disease severity in patients with moderate to severe acute respiratory distress syndrome
Plasma surrogate markers of neutrophil extracellular traps correlate with disease severity in patients with moderate to severe acute respiratory distress syndrome
Although studies have evaluated the presence of cell-free DNA and neutrophil extracellular traps (NETs) in acute respirato...
Intermittent methionine restriction and selenium supplementation protect against inflammation and the development of dermatitis
Intermittent methionine restriction and selenium supplementation protect against inflammation and the development of dermatitis
Dietary methionine restriction (MR) produces multiple metabolic health benefits and extends the healthspan of several mode...
Mesenchymal stem cell-derived exosomal CBLB ameliorates infantile pneumonia progression probably by ubiquitinating MAPK14
Mesenchymal stem cell-derived exosomal CBLB ameliorates infantile pneumonia progression probably by ubiquitinating MAPK14
Infantile pneumonia (IP) is a significant cause of morbidity and mortality in young children. Mesenchymal stem cells (MSCs...
The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila melanogaster and cellular models of alzheimer’s disease
The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila melanogaster and cellular models of alzheimer’s disease
Alzheimer’s disease (AD) is a common neurodegenerative disease, and its pathogenesis is closely associated with neur...
Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation
Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation
Transfer RNA-derived small RNAs (tsRNAs) are a newly discovered class of small noncoding RNAs (sncRNAs) that include tRNA-...
Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes
Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes
Sepsis-induced myocardial dysfunction (SIMD) may contribute to the poor prognosis of septic patients. Carvacrol (2-methyl-...
Non-ionic surfactant vesicles exert anti-inflammatory effects through inhibition of NFκB
Non-ionic surfactant vesicles exert anti-inflammatory effects through inhibition of NFκB
Inflammation can be an unwanted consequence or cause of debilitating diseases of infectious and non-infectious aetiologies...
Macrophage involvement in idiopathic inflammatory myopathy: pathogenic mechanisms and therapeutic prospects
Macrophage involvement in idiopathic inflammatory myopathy: pathogenic mechanisms and therapeutic prospects
Idiopathic inflammatory myopathies are a group of systemic autoimmune diseases characterized by chronic muscle inflammatio...
MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation
MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation
Transforming Growth Factor Beta1 (TGF-β1) signaling is upregulated in Chronic Obstructive Pulmonary disease (COPD), s...
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways
Intervertebral disc degeneration (IVDD) is a common spine disease with inflammation as its main pathogenesis. Mulberroside...
The effects of chronic, continuous β-funaltrexamine pre-treatment on lipopolysaccharide-induced inflammation and behavioral deficits in C57BL/6J mice
The effects of chronic, continuous β-funaltrexamine pre-treatment on lipopolysaccharide-induced inflammation and behavioral deficits in C57BL/6J mice
Inflammation and neuroinflammation are integral to the progression and severity of many diseases and are strongly associat...
Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model
Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model
Sonic Hedgehog (Shh), extensively researched for its role in early neurogenesis and brain development, has recently been r...
Correction: PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Correction: PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
Asthma is a prevalent respiratory inflammatory disease. Abnormal apoptosis of bronchial epithelial cells is one of the maj...
Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway
Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway
Interplay between systemic inflammation and programmed cell death contributes to the pathogenesis of acute lung injury (AL...
Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD
Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD
Exposure to noxious particles, including cigarette smoke and fine particulate matter (PM2.5), is a risk factor for chronic...
Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex
Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex
The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) ...
Coarse particulate matter (PM10) induce an inflammatory response through the NLRP3 activation
Coarse particulate matter (PM10) induce an inflammatory response through the NLRP3 activation
PM exposure can induce inflammatory and oxidative responses; however, differences in these adverse effects have been repor...
Retraction Note: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
Retraction Note: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. The...
SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia
SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia
The recent pandemic outbursts, due to SARS-CoV-2, have highlighted once more the central role of the inflammatory process ...
Lipid from electronic cigarette-aerosol both with and without nicotine induced pro-inflammatory macrophage polarization and disrupted phagocytosis
Lipid from electronic cigarette-aerosol both with and without nicotine induced pro-inflammatory macrophage polarization and disrupted phagocytosis
Clinical cases and experimental evidence revealed that electronic cigarettes (ECIG) induce serious adverse health effects,...
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway
Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway infl...
The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
Diabetes mellitus is one of the causes of poor ventricular remodelling and poor cardiac recovery after myocardial infarcti...
Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Fermented butyrate exhibits an anti-inflammatory response to maintain immune homeostasis within the gut. However, the effe...
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inf...
IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions
IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are life threatening pulmonar...
Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates
Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates
Cardiometabolic diseases are associated with low-grade inflammation early in life and persists into old age. The long late...
Advances in the study of macrophage polarization in inflammatory immune skin diseases
Advances in the study of macrophage polarization in inflammatory immune skin diseases
When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-in...
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