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Redefining CNS immune privilege
Redefining CNS immune privilege
The central nervous system (CNS) has a unique relationship with the immune system, referred to as immune privilege. For ma...
Progenitor exhausted T cells contribute to the formation of immunological memory
A preprint by Raposo et al. shows that immune checkpoint blockade drives the expansion of certain clones of exhausted T ce...
CD45-PET imaging gives a panoramic view of in vivo immune activity
In this Tools of the Trade article, Sina Djafari Rouhani and Mohammad Rashidian describe CD45-PET for whole-body imaging o...
In vivo CAR engineering for immunotherapy
In vivo CAR engineering for immunotherapy
Chimeric antigen receptor (CAR)-engineered immune cell therapy represents an important advance in cancer treatments. Howev...
Releasing the brakes on phagosomes
A preprint by Cheng et al. identifies the proton-activated chloride channel PAC as a negative regulator of phagosomal acid...
Can we improve immune health by restoring microbial biodiversity?
Can we improve immune health by restoring microbial biodiversity?
Diverse microbial exposures in early life reduce the risk of inflammatory conditions, including allergies and autoimmunity...
Inhibitory pattern recognition receptors: lessons from LAIR1
Inhibitory pattern recognition receptors: lessons from LAIR1
Many inhibitory receptors that regulate immune cell function recognize a limited number of specific ligands. However, a su...
Insights into immune cell–fibroblast communication in heart disease
Inflammation and fibrosis are linked to organ dysfunction. Two studies in Nature investigate the cross-talk between immune...
Decoding the human prenatal immune system with single-cell multi-omics
Decoding the human prenatal immune system with single-cell multi-omics
The human immune system is made up of a huge variety of cell types each with unique functions. Local networks of resident ...
The danger theory of immunity revisited
The danger theory of immunity revisited
The danger theory of immunity, introduced by Polly Matzinger in 1994, posits that tissue stress, damage or infection has a...
Adipokines: masterminds of metabolic inflammation
Adipokines: masterminds of metabolic inflammation
Adipose tissue is an immunologically active organ that controls host physiology, partly through the release of mediators t...
Charge-based immunoreceptor signalling in health and disease
Charge-based immunoreceptor signalling in health and disease
Immunoreceptors have crucial roles in sensing environmental signals and initiating immune responses to protect the host. D...
Viral infection and antiviral immunity in the oral cavity
Viral infection and antiviral immunity in the oral cavity
Individual tissues have distinct antiviral properties garnered through various mechanisms, including physical characterist...
Innate lymphoid cell control of neuronal synapse development
Innate lymphoid cell control of neuronal synapse development
ILC2s promote inhibitory synapse formation in the postnatal mouse brain through the production of IL-13.
Integrating natural commensals and pathogens into preclinical mouse models
Integrating natural commensals and pathogens into preclinical mouse models
Fundamental discoveries in many aspects of mammalian physiology have been made using laboratory mice as research models. T...
How bile acids and the microbiota interact to shape host immunity
How bile acids and the microbiota interact to shape host immunity
Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various host processes. Similarly, ...
Pyroptotic cell products promote tissue repair
Pyroptotic cell products promote tissue repair
The pyroptotic secretome can be beneficial in promoting tissue repair.
CD28 co-stimulation: novel insights and applications in cancer immunotherapy
CD28 co-stimulation: novel insights and applications in cancer immunotherapy
Substantial progress in understanding T cell signalling, particularly with respect to T cell co-receptors such as the co-s...
How neuroinflammation weakens muscles
How neuroinflammation weakens muscles
Neuroinflammation in response to infection or chronic disease can cause non-neural symptoms such as fatigue and muscle pai...
Early life antibiotics have lasting effects on the lung epithelium
Early life antibiotics have lasting effects on the lung epithelium
Transient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-...
Location matters: mapping antigen receptors within tissues
Location matters: mapping antigen receptors within tissues
In this Tools of the Trade article, Camilla Engblom and colleagues describe their elegant technique ‘Spatial VDJR...
Non-classical monocytes have the support of the whole vascular tree
Thierry, Baudon et al. show that non-classical monocytes are nurtured by endothelial cell expression of CSF1 throughout th...
Mechanisms of antibody-dependent enhancement of infectious disease
Mechanisms of antibody-dependent enhancement of infectious disease
Antibody-dependent enhancement (ADE) of infectious disease is a phenomenon whereby host antibodies increase the severity o...
A pre-TCRα-independent pathway of αβ T cell differentiation
A pre-TCRα-independent pathway of αβ T cell differentiation
A study in Science reports 10 individuals with pre-TCRα deficiency who have late-onset or no clinical phenotype, whic...
PANINI: Combined protein and nucleic acid imaging in tissues
Sizun Jiang (while in the Garry Nolan lab) describes a method termed PANINI that allows simultaneous detection of nucleic ...
Short-chain fatty acids: linking diet, the microbiome and immunity
Short-chain fatty acids: linking diet, the microbiome and immunity
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial metabolites and their availability in t...
Rejuvenating an old immune system
Depletion of myeloid-biased haematopoietic stem cells can mitigate age-associated immune dysfunction.
Neuronal TLR9 signalling crucial for memory formation
Memories are encoded by microcircuits of hippocampal neurons. These cells undergo energy-intensive molecular adaptations d...
Tumour cell consumption of taurine exhausts CD8+ T cells
The amino acid taurine is marketed as a nutritional supplement. Cao et al. now show that taurine can enhance the malignant...
Bacterial serotonin induces Treg cells in neonates
The gut microbiota has a crucial role in immune development in early life. Sanidad et al. show that the mouse neonatal sma...
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