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β-hydroxybutyrylation and O-GlcNAc modifications of STAT1 modulate antiviral defense in aging
β-hydroxybutyrylation and O-GlcNAc modifications of STAT1 modulate antiviral defense in aging
Aging changes the protein activity status to affect the body’s functions. However, how aging regulates protein postt...
Gut-derived macrophages link intestinal damage to brain injury after cardiac arrest through TREM1 signaling
Gut-derived macrophages link intestinal damage to brain injury after cardiac arrest through TREM1 signaling
Brain injury is the leading cause of death and disability in survivors of cardiac arrest, where neuroinflammation triggere...
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming
Macrophage polarization and energy metabolic reprogramming play pivotal roles in the onset and progression of inflammatory...
On the origin of neutrophils
On the origin of neutrophils
Hidalgo A, Chilvers ER, Summers C, Koenderman L. The neutrophil life cycle. Trends Immunol. 2019;40:584–97.Article  CA...
Inflammation-triggered Gli1+ stem cells engage with extracellular vesicles to prime aberrant neutrophils to exacerbate periodontal immunopathology
Inflammation-triggered Gli1+ stem cells engage with extracellular vesicles to prime aberrant neutrophils to exacerbate periodontal immunopathology
Periodontitis is a prevalent and progressive detrimental disease characterized by chronic inflammation, and the immunopath...
GPNMB disrupts SNARE complex assembly to maintain bacterial proliferation within macrophages
GPNMB disrupts SNARE complex assembly to maintain bacterial proliferation within macrophages
Xenophagy plays a crucial role in restraining the growth of intracellular bacteria in macrophages. However, the machinery ...
Systematic mining and quantification reveal the dominant contribution of non-HLA variations to acute graft-versus-host disease
Systematic mining and quantification reveal the dominant contribution of non-HLA variations to acute graft-versus-host disease
Human leukocyte antigen (HLA) disparity between donors and recipients is a key determinant triggering intense alloreactivi...
Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia
Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia
Autologous T-cell therapies show limited efficacy in chronic lymphocytic leukemia (CLL), where acquired immune dysfunction...
Regulation of CD8+ T cells by lipid metabolism in cancer progression
Regulation of CD8+ T cells by lipid metabolism in cancer progression
Dysregulation of lipid metabolism is a key characteristic of the tumor microenvironment, where tumor cells utilize lipids ...
No more LAGging behind PD-1: uncovering the unique role of LAG-3 in T-cell exhaustion
No more LAGging behind PD-1: uncovering the unique role of LAG-3 in T-cell exhaustion
Zander R, Cui W. Exhausted CD8(+) T cells face a developmental fork in the road. Trends Immunol. 2023;44:276–86.Article  ...
4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20
4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20
CD28 and 4-1BB costimulatory endodomains included in chimeric antigen receptor (CAR) molecules play a critical role in pro...
Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma
Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma
Metabolic changes play a crucial role in determining the status and function of macrophages, but how lipid reprogramming i...
BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells
BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells
Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer (PC) progre...
Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells ...
Food restriction heals darkness-related second brain inflammation
Food restriction heals darkness-related second brain inflammation
Koronowski KB, Kinouchi K, Welz PS, Smith JG, Zinna VM, Shi J, et al. Defining the Independence of the Liver Circadian Clo...
Extramedullary neutrophil progenitors: Quo Vadis?
Extramedullary neutrophil progenitors: Quo Vadis?
Billard MJ, Gruver AL, Sempowski GD. Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory a...
Targeting pro-fibrotic macrophages with bioactive self-assembly peptides to retard kidney fibrosis – know thyself
Targeting pro-fibrotic macrophages with bioactive self-assembly peptides to retard kidney fibrosis – know thyself
Ouyang Q, Wang C, Sang T, Tong Y, Zhang J, Chen Y, et al. Depleting profibrotic macrophages using bioactivated in vivo ass...
Orchestration of antiviral responses within the infected central nervous system
Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global rese...
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author notesThese authors contributed equally: Hanhui Zhong, Jingjing Ji, Jinling Zhuang.Authors and AffiliationsThe Depar...
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Marginal zone (MZ) B cells, which are splenic innate-like B cells that rapidly secrete antibodies (Abs) against b...
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
Apart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our gr...
Development of NK cell-based cancer immunotherapies through receptor engineering
Development of NK cell-based cancer immunotherapies through receptor engineering
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field of cancer treatment. Early ...
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
The overexpression of sialic acids on glycans, called hypersialylation, is a common alteration found in cancer cells. Sial...
Neutrophils in the tumor microenvironment – when a company becomes a crowd
Neutrophils in the tumor microenvironment – when a company becomes a crowd
Traditionally, neutrophils are perceived as terminally differentiated cells with defined functions an...
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the...
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Acetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role...
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to the immunosuppressive tumor microenv...
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
A highly immunosuppressive tumor microenvironment (TME) and the presence of the blood‒brain barrier are the two majo...
Interleukin-10 multitasking in allergic airway inflammation
Interleukin-10 multitasking in allergic airway inflammation
Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391:783–800.Article  PubMed  ...
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
Functional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity...
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