Mattiuzzi C, Lippi G. Current Cancer Epidemiology. J Epidemiol Glob Health. 2019;9:217–22. https://doi.org/10.2991/jegh.k.191008.001.
Article PubMed PubMed Central Google Scholar
Swanton C, Bernard E, Abbosh C, André F, Auwerx J, Balmain A, et al. Embracing cancer complexity: Hallmarks of systemic disease. Cell. 2024;187:1589–616. https://doi.org/10.1016/j.cell.2024.02.009.
Article PubMed CAS Google Scholar
Esposito M, Ganesan S, Kang Y. Emerging strategies for treating metastasis. Nat Cancer. 2021;2:258–70. https://doi.org/10.1038/s43018-021-00181-0.
Article PubMed PubMed Central Google Scholar
Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022;12:31–46. https://doi.org/10.1158/2159-8290.CD-21-1059.
Article PubMed CAS Google Scholar
Cockcroft S. Mammalian lipids: structure, synthesis and function. Essays Biochem. 2021;65:813–45. https://doi.org/10.1042/EBC20200067.
Article PubMed PubMed Central CAS Google Scholar
Hodson L, Gunn PJ. The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state. Nat Rev Endocrinol. 2019;15:689–700. https://doi.org/10.1038/s41574-019-0256-9.
Article PubMed CAS Google Scholar
Zhang W, Xu L, Zhu L, Liu Y, Yang S, Zhao M. Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System. Front Physiol. 2021;12:746749. https://doi.org/10.3389/fphys.2021.746749.
Article PubMed PubMed Central Google Scholar
Ikonen E, Zhou X. Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes. Dev Cell. 2021;56:1430–6. https://doi.org/10.1016/j.devcel.2021.04.025.
Article PubMed CAS Google Scholar
Song Y, Liu J, Zhao K, Gao L, Zhao J. Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases. Cell Metab. 2021;33:1911–25. https://doi.org/10.1016/j.cmet.2021.09.001.
Article PubMed CAS Google Scholar
Jain A, Zoncu R. Organelle transporters and interorganelle communication as drivers of metabolic regulation and cellular homeostasis. Mol Metab. 2022;60:101481. https://doi.org/10.1016/j.molmet.2022.101481.
Article PubMed PubMed Central CAS Google Scholar
Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol. 2000;16:145–71. https://doi.org/10.1146/annurev.cellbio.16.1.145.
Article PubMed CAS Google Scholar
Morigny P, Boucher J, Arner P, Langin D. Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. Nat Rev Endocrinol. 2021;17:276–95. https://doi.org/10.1038/s41574-021-00471-8.
Article PubMed CAS Google Scholar
Song Z, Xiaoli AM, Yang F. Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues. Nutrients. 2018;10:1383. https://doi.org/10.3390/nu10101383.
Article PubMed PubMed Central CAS Google Scholar
Jones JG. Hepatic glucose and lipid metabolism. Diabetologia. 2016;59:1098–103. https://doi.org/10.1007/s00125-016-3940-5.
Article PubMed CAS Google Scholar
Sakers A, De Siqueira MK, Seale P, Villanueva CJ. Adipose-tissue plasticity in health and disease. Cell. 2022;185:419–46. https://doi.org/10.1016/j.cell.2021.12.016.
Article PubMed PubMed Central CAS Google Scholar
Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999;103:1489–98. https://doi.org/10.1172/JCI6223.
Article PubMed PubMed Central CAS Google Scholar
Qian X, Yang Z, Mao E, Chen E. Regulation of fatty acid synthesis in immune cells. Scand J Immunol. 2018;88:e12713. https://doi.org/10.1111/sji.12713.
Article PubMed CAS Google Scholar
Kohli GS, John U, Van Dolah FM, Murray SA. Evolutionary distinctiveness of fatty acid and polyketide synthesis in eukaryotes. ISME J. 2016;10:1877–90. https://doi.org/10.1038/ismej.2015.263.
Article PubMed PubMed Central Google Scholar
Stark JM, Tibbitt CA, Coquet JM. The Metabolic Requirements of Th2 Cell Differentiation. Front Immunol. 2019;10:2318. https://doi.org/10.3389/fimmu.2019.02318.
Article PubMed PubMed Central CAS Google Scholar
Lee J, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T-cell immunity. J Immunol. 2014;192:3190–9. https://doi.org/10.4049/jimmunol.1302985.
Article PubMed CAS Google Scholar
Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, et al. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol. 2013;14:489–99. https://doi.org/10.1038/ni.2570.
Article PubMed PubMed Central CAS Google Scholar
Su W, Chapman NM, Wei J, Zeng H, Dhungana Y, Shi H, et al. Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T(reg) Cells. Cell Metab. 2020;32:996–1011. https://doi.org/10.1016/j.cmet.2020.10.022.
Article PubMed PubMed Central CAS Google Scholar
Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, et al. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene. 2005;24:6465–81. https://doi.org/10.1038/sj.onc.1208802.
Article PubMed CAS Google Scholar
Luo J, Yang H, Song BL. Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 2020;21:225–45. https://doi.org/10.1038/s41580-019-0190-7.
Article PubMed CAS Google Scholar
Bao C, Wu T, Zhu S, Wang X, Zhang Y, Wang X, et al. Regulation of cholesterol homeostasis in osteoporosis mechanisms and therapeutics. Clin Sci. 2023;137:1131–43. https://doi.org/10.1042/CS20220752.
Bartlett K, Eaton S. Mitochondrial beta-oxidation. Eur J Biochem. 2004;271:462–9. https://doi.org/10.1046/j.1432-1033.2003.03947.x.
Article PubMed CAS Google Scholar
Su X, Abumrad NA. Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab. 2009;20:72–77. https://doi.org/10.1016/j.tem.2008.11.001.
Article PubMed PubMed Central CAS Google Scholar
Senzaki H, Iwamoto S, Ogura E, Kiyozuka Y, Arita S, Kurebayashi J, et al. Dietary effects of fatty acids on growth and metastasis of KPL-1 human breast cancer cells in vivo and in vitro. Anticancer Res. 1998;18:1621–7.
Comments (0)