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SCI Abstract
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Engineered bispecific antibodies with enhanced breadth and potency against SARS-CoV-2 variants and SARS-related coronaviruses
The concern of COVID-19 persists due to the continuous emergence of variants and the potential spillover of animal coronav...
Medical Microbiology And Immunology
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MPXV infection impairs IFN response but is partially sensitive to IFN-γ antiviral effect
The recent outbreak of monkeypox virus (MPXV) has caused global concern. How the virus evades the interferon (IFN) respons...
Medical Microbiology And Immunology
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Construction and evaluation of glycoprotein-based nucleic acid vaccines for Marburg virus
Marburg virus (MARV) is a zoonotic virus that can infect humans and non-human primates (NHPs) and lead to a fatal Marburg ...
Medical Microbiology And Immunology
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Significance of diagnostic and therapeutic potential of serum endothelial and inflammatory biomarkers in defining disease severity of dengue infected patients
Dengue virus (DENV) mediated disease severity leads to fatality among infected patients. Immune sentinels recognize DENV t...
Medical Microbiology And Immunology
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Proportions of IgA antibodies targeting glycosylated epitopes of secreted Escherichia coli mucinase YghJ in initial plasmablast response differ from salivary and intestinally secreted IgA
Mucosal infections normally cause an immune response including activation of antigen-specific B cells in regional mucosa-a...
Medical Microbiology And Immunology
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Deciphering long-term immune effects of HIV-1/SARS-CoV-2 co-infection: a longitudinal study
While the general immune response to Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is well-understood, the ...
Medical Microbiology And Immunology
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In silico identification and ex vivo evaluation of Toxoplasma gondii peptides restricted to HLA-A*02, HLA-A*24 and HLA-B*35 alleles in human PBMC from a Colombian population
Toxoplasma gondii infects approximately 30% of the population, and there is currently no approved vaccine. Identifying imm...
Medical Microbiology And Immunology
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Dissemination of arr-2 and arr-3 is associated with class 1 integrons in Klebsiella pneumoniae clinical isolates from Portugal
\nKlebsiella pneumoniae is a common pathogen of healthcare-associated infections expressing a plethora of antimicrobial re...
Medical Microbiology And Immunology
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Cytolethal distending toxin-producing Escherichia coli clinical isolates from Mexican children harbor different cdt types causing CDT-induced epithelial pathological phenotypes
Cytolethal distending toxins (CDTs), encoded by cdtABC genes, have DNase activity leading to cellular and nuclear distenti...
Medical Microbiology And Immunology
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Fungal infection monitoring on corneal epithelium ex vivo model and its collection over polyethersulfone membrane for detecting Candida albicans and Aspergillus fumigatus
In this paper we report a human ex vivo model of Aspergillus fumigatus and Candida albicans infection of the cornea. We de...
Medical Microbiology And Immunology
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Protective antibodies against enterotoxigenic Escherichia coli are generated from heat-labile toxoid vaccination and exhibit subject- and vaccine-specific diversity
Heat-labile toxin (LT) from enterotoxigenic Escherichia coli (ETEC) is an important pathogenic protein. Anti-LT antibodies...
Medical Microbiology And Immunology
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Production of recombinant electron transfer flavoprotein beta subunit protein and its application in a lateral flow assay for early diagnosis of leptospirosis
Leptospirosis is a major cause of acute febrile illness, often presenting with non-specific symptoms that can lead to misd...
Medical Microbiology And Immunology
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miRNome analysis reveals mir-155-5p as a protective factor to dengue infection in a resistant Thai cohort
Dengue virus (DENV) is a global health threat, with approximately 390 million infections annually, ranging from m...
Medical Microbiology And Immunology
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Understanding host–pathogen interaction: paving the path for individualized anti-infective therapy
In the COVID-19 pandemic, we were challenged by the spread of SARS-CoV2, a virus not ...
Medical Microbiology And Immunology
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Quantitative assay to analyze neutralization and inhibition of authentic Middle East respiratory syndrome coronavirus
To date, there is no licensed vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV). Therefore, MERS-CoV is ...
Medical Microbiology And Immunology
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One-dose intradermal rabies booster enhances rabies antibody production and avidity maturation
The incidence of rabies in Thailand reached its peak in 2018 with 18 human deaths. Preexposure prophylaxis (PrEP) vaccinat...
Medical Microbiology And Immunology
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Lipopolysaccharide with long O-antigen is crucial for Salmonella Enteritidis to evade complement activity and to facilitate bacterial survival in vivo in the Galleria mellonella infection model
Bacterial resistance to serum is a key virulence factor for the development of systemic infections. The amount of lipopoly...
Medical Microbiology And Immunology
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Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility
Background: Obesity-associated male infertility is a common complication of obesity and has been increasing in prevalence....
Medical Microbiology And Immunology
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Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Mycobacterium tuberculosis, a lethal pathogen in human history, causes millions of deaths annually, which demands the deve...
Medical Microbiology And Immunology
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Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Chlamydiae are a large group of obligate endosymbionts of eukaryotes that includes the Chlamydiaceae family, comprising se...
Medical Microbiology And Immunology
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Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, an intracellular pathogen with a high mort...
Medical Microbiology And Immunology
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Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases
Carl Flügge is best known for the promotion of studies demonstrating the transmission of all manner of infections, bu...
Medical Microbiology And Immunology
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Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Outbreaks of emerging diseases, like Mpox in 2022, pose unprecedented challenges to global healthcare systems. Although Mp...
Medical Microbiology And Immunology
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Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus
The Panton-Valentine leukocidin (PVL) of Staphylococcus aureus is associated with necrotizing infections. After binding to...
Medical Microbiology And Immunology
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Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV)
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a globally significant vector-borne pathogen with no internationally-lice...
Medical Microbiology And Immunology
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Trivalent outer membrane vesicles-based combination vaccine candidate induces protective immunity against Campylobacter and invasive non-typhoidal Salmonella in adult mice
Campylobacter and invasive non-typhoidal Salmonella (iNTS) are among the most common causative agents of gastroenteritis w...
Medical Microbiology And Immunology
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A plant-based oligomeric CD2v extracellular domain antigen exhibits equivalent immunogenicity to the live attenuated vaccine ASFV-G-∆I177L
African swine fever (ASF), caused by the African swine fever virus (ASFV), is a deadly, highly contagious disease in both ...
Medical Microbiology And Immunology
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The pathogenic responses elicited during exposure of human intestinal cell line with Giardia duodenalis excretory-secretory products and the potential attributed endocytosis mechanism
Giardia duodenalis, an important zoonotic protozoan parasite, adheres to host intestinal epithelial cells (IECs) via the v...
Medical Microbiology And Immunology
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Advances in the understanding of circRNAs that influence viral replication in host cells
Circular RNAs (circRNAs) are non-coding RNAs discovered in recent years, which are produced by back-splicing involving the...
Medical Microbiology And Immunology
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Inflammation, the kynurenines, and mucosal injury during human experimental enterotoxigenic Escherichia coli infection
Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in children and travelers, especially in low- an...
Medical Microbiology And Immunology
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