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Evaluation of Patients with Combined Immunodeficiency: A Single Center Experience
Background: Severe combined immunodeficiency (SCID) is the most severe form of inborn errors of immunity (IEIs) and typica...
Soluble HLA-E and Gastroesophageal Reflux Disease: A Novel Association‎
Background: Gastroesophageal reflux disease (GERD) is a prevalent clinical condition that affects millions of individuals ...
Evaluation of Dendritic Cell Subpopulations Frequency in COVID-19 Patients and their Correlation with Disease Severity
Background: COVID-19 (2019) clearly demonstrates an imbalanced immune response. Variations in the function and subtypes of...
circ_0001006 Promotes Immune Escape in Non-small Cell Lung Cancer by Regulating the miR-320a/PD-L1 Axis
Background: Circular RNAs are involved in the tumorigenesis of various tumors, including Non-small cell lung cancer (NSCLC...
Low-dose Radiation Improves Tumor Immune Microenvironment, Enhancing the Effects of Anti-CTLA-4 Therapy
Background: Radiotherapy destroys tumor cells primarily through direct DNA damage by high-energy particles or indirect DNA...
MicroRNA-146a Inhibits Progression and Immune Evasion in Diffuse Large B-cell Lymphomas by Targeting Programmed Cell Death Ligand 1
Background: Earlier studies have highlighted the involvement of miRNA146a in tumor suppression indicating its potential to...
CX3CR1 Functions as a Biomarker Associated with Pathological Tumor Staging in ‎the Diagnosis and Prognosis of Prostate Cancer
Background: Previous research has identified several potential biomarkers associated with pathological tumor (pT) staging ...
Transmembrane TNF-α Reverse Signaling Alleviates Lipopolysaccharide-induced ‎Inflammation by Regulating the MCPIP1/SIRT1/NF-κB Pathway
Background: Studies have demonstrated that transmembrane tumor necrosis factor-α (tmTNF-α) plays an anti-inflammatory role...
Interaction Between Tfh/Tfr Ratio and Regulatory B Cell in Autoimmune Diseases
The balance between follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) is crucial for maintaining imm...
Comments on "Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice"
Saffaei, A., Amani, J., Salimian, J., Alishiri, G., Abolghasemi, H. (2024). 'Comments on "Com...
IgG4-Related Disease in a 90-Year-Old Man with an 18-Year Disease Course: A Case Report
IgG4-related disease (IgG4-RD) is a multi-organ inflammatory immune-mediated illness caused by IgG4-secreting plasma cells...
The Impact of Wharton’s Jelly-derived Exosomes on the Production of Inflammatory Mediators from HIG-82 Synoviocytes
Background: Osteoarthritis (OA) is the most common joint disease worldwide. Routine treatment options are limited, and tot...
Prognostic Value of CD14 Expression in Peripheral Blood Mononuclear Cell Membrane in Patients with Severe COPD Complicated with Pulmonary Infection
Background: Severe chronic obstructive pulmonary disease (COPD) patients with pulmonary infections face higher morbidity a...
The Protective Role of IL-17 and IL-22 in COVID-19 Infection
Background: The development of a cytokine storm in Coronavirus Disease 2019 (COVID-19) infection can make the disease fata...
Modulation of M1/M2 Cytokines and Inflammatory Enzymes by Persicaria Species Leaf Extracts in Lipopolysaccharide-stimulated RAW 264.7 Cell Macrophages
Background: Investigating the impacts of plant-based substances on the regulation of pro-inflammatory M1 and anti-inflamma...
miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosis
Background: miR-196b-5p was found to be significantly reduced in endometriosis, but its function and the mechanisms involv...
JAK/STAT Signaling Pathway Mediates Anti-Tumor Immunity of CD8+ T Cells in Renal Cancer
Background: CD8+ T cells play a crucial role in immune responses, and have significant potential in tumor immunotherapy. T...
Letter to the Editor Regarding “Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity”
Dear Editor I am writing in response to the recently published study titled "Antibody Production after COVID-19 Vacc...
MicroRNA-150 Deletion Reduces the Occurrence and Severity of Rheumatoid Arthritis by Inhibiting IL-17
Background: Understanding the effects of epigenetic factors on the pathogenesis of rheumatoid arthritis (RA) is important ...
Abnormal Changes in IL-13 and IL-17A Serum Levels in Children with Adenovirus Pneumonia and their Diagnostic Value
Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage...
IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans
Background: Pulmonary neutrophils may play a crucial role in the development of bronchiolitis obliterans (BO) following me...
Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors
Background: Tumor-infiltrating lymphocytes (TILs) and brain stromal cells produce immunosuppressive cytokines, contributin...
Intervention with ICOSL Antibodies Alleviates Inflammatory Infiltrations in Mice with Neutrophilic Asthma
Background: Neutrophilic asthma is characterized by the predominant infiltration of neutrophils in airway inflammation.Obj...
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment
Background: The imbalance between M1 and M2 macrophage activation is closely associated with the pathogenesis of inflammat...
Immunohistochemical Evaluation of NKP46 Receptor Expression and the Number of NK Cells in the Endometrium of Patients with Endometriosis
Background: Endometriosis is a medical condition that can cause infertility in women. Women with endometriosis experience ...
The Ratio of Peripheral Blood Natural Killer Cells is not a Solid Surrogate Immune Index in Unexplained Recurrent Miscarriage
Background: Immunotherapies targeting peripheral natural killer (pbNK) cells in unexplained recurrent miscarriage (uRM) re...
Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice
Background: Since the outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccine ...
Human Umbilical Cord Mesenchymal Stem Cells and Their Extracellular Vesicles Modulate Pro- and Anti-Inflammatory Cytokines in Ligature-induced Periodontitis
Background: Periodontitis is a persistent inflammatory condition that impacts the tissues supporting the teeth, ultimately...
Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia
Background: Thymocyte selection-associated high mobility group box protein (TOX) and members of the nuclear receptor 4A (N...
Rescue of HLH with T and B Lymphocyte Involvement Due to Epstein-Barr Virus by PD-1 Inhibitor/Ruxolitinib and Rituximab Combination Regimens: A Case Report
Hemophagocytic lymphohistiocytosis (HLH) is a fatal clinical syndrome. The most common cause of secondary HLH is Epstein-B...
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