SCI Abstract

search
+
tRNA-derived fragments: biomarkers and therapeutic targets in autoimmune diseases
tRNA-derived fragments: biomarkers and therapeutic targets in autoimmune diseases
TRNA-derived fragments (tRFs) are tiny non-coding RNAs that control gene expression and immunological responses. Initially...
A novel variant in the STIM1 gene leading to combined immunodeficiency and congenital myopathy
A novel variant in the STIM1 gene leading to combined immunodeficiency and congenital myopathy
Stromal interaction molecule 1 (STIM1) is a transmembrane protein located in the endoplasmic and sarcoplasmic reticulum, w...
T-cell activation enhances anti-HER2-mediated antibody-dependent cellular cytotoxicity in gastric cancer
T-cell activation enhances anti-HER2-mediated antibody-dependent cellular cytotoxicity in gastric cancer
Anti-HER2 monoclonal antibody (mAb) is the standard first-line therapy for advanced HER2+ gastric cancer. However, resista...
Post-COVID-19 era sero-surveillance of anti-measles IgM and IgG antibodies among asymptomatic Tanzanian children aged 3 to 15 years Journal
Post-COVID-19 era sero-surveillance of anti-measles IgM and IgG antibodies among asymptomatic Tanzanian children aged 3 to 15 years Journal
In July 2022, during the COVID-19 era, Tanzania reported over 1500 laboratory-confirmed measles cases and more than 30 dea...
Role of the basophil activation test in the diagnosis and management of immediate drug reaction to injectable growth hormone preparation: a case report
Role of the basophil activation test in the diagnosis and management of immediate drug reaction to injectable growth hormone preparation: a case report
Hypersensitivity reactions to synthetic hormones are rare but can represent serious complications. Allergic responses to s...
STAT3 inhibition mitigates experimental autoimmune gastritis by restoring Th17/Treg immune balance
STAT3 inhibition mitigates experimental autoimmune gastritis by restoring Th17/Treg immune balance
This study investigates the role of STAT3 in autoimmune gastritis (AIG) pathogenesis and evaluates the therapeutic potenti...
Deucravacitinib as a monotherapy for concurrent management of psoriasis and chronic spontaneous urticaria
Deucravacitinib as a monotherapy for concurrent management of psoriasis and chronic spontaneous urticaria
Patients with autoimmune diseases are susceptible to developing a second autoimmune disorder. Psoriasis, a common autoimmu...
The cGAS-STING axis: a comprehensive review from immune defense to disease pathogenesis
The cGAS-STING axis: a comprehensive review from immune defense to disease pathogenesis
The cGAS-STING pathway is a critical signaling mechanism in the innate immune system for sensing cytosolic DNA and subsequ...
The mechanism of p38 MAPK, NF-κB, and IL-6 in T-2 toxin and/or selenium deficiency induced spleen injury
The mechanism of p38 MAPK, NF-κB, and IL-6 in T-2 toxin and/or selenium deficiency induced spleen injury
Both T-2 toxin and selenium (Se) cause immune impairment in the spleen, but the mechanism of their occurrence is not clear...
α-hemolysin induces DNA methylation changes in human Th1 cells
α-hemolysin induces DNA methylation changes in human Th1 cells
α-Hemolysin is one of the most dangerous virulence factors produced by Staphylococcus aureus. Among the immune cells ...
FOXO1 contributes to cigarette smoke condensate–induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway
FOXO1 contributes to cigarette smoke condensate–induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway
Cigarette smoking is the most dominant factor contributing to chronic obstructive pulmonary disease (COPD). Fibroblasts ar...
The relationship between self-reported immune fitness and salivary immune biomarker concentrations
The relationship between self-reported immune fitness and salivary immune biomarker concentrations
Immune fitness refers to the body’s ability to respond to health challenges by activating an appropriate immune resp...
Statins and adhesion molecules: a review of a novel pleiotropic property of statins
Statins and adhesion molecules: a review of a novel pleiotropic property of statins
Statins were introduced as lipid-lowering agents that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase; ...
High expression of signal regulatory protein beta 2 marks a favourable prognostic AML subgroup and associates with increased sensitivity to phagocytosis
High expression of signal regulatory protein beta 2 marks a favourable prognostic AML subgroup and associates with increased sensitivity to phagocytosis
Acute myeloid leukaemia is an aggressive hematologic malignancy that remains exceedingly difficult to treat despite recent...
Immunomodulatory activity of 4-(Benzyloxy)phenol facilitates intracellular mycobacterial clearance through p53 mediated IL-35 signaling dependent JAK1/STAT3 pathway in human macrophages
Immunomodulatory activity of 4-(Benzyloxy)phenol facilitates intracellular mycobacterial clearance through p53 mediated IL-35 signaling dependent JAK1/STAT3 pathway in human macrophages
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), modulates host immune responses by...
The epidemiological trends of inflammatory bowel disease among women of reproductive age: a global analysis from 1990 to 2021
The epidemiological trends of inflammatory bowel disease among women of reproductive age: a global analysis from 1990 to 2021
This study aimed to evaluate the global burden of inflammatory bowel disease (IBD) among women of reproductive age (15R...
HBV infection upregulates GP73 expression to promote liver fibrosis by enhancing ER stress via the Smad2 pathway
HBV infection upregulates GP73 expression to promote liver fibrosis by enhancing ER stress via the Smad2 pathway
Endoplasmic reticulum (ER) stress induced by hepatitis B virus (HBV) infection is associated with the development of liver...
Immunomodulatory activities of carbon quantum dots on the primary macrophages and whole splenocytes
Immunomodulatory activities of carbon quantum dots on the primary macrophages and whole splenocytes
Quantum dots, because of some of their fascinating features, like continuous radiation emission, crossing the biological b...
Risk factors for infections in systemic lupus erythematosus: a meta-analysis
Risk factors for infections in systemic lupus erythematosus: a meta-analysis
Immune dysfunction in patients with systemic lupus erythematosus (SLE) increases susceptibility to infections, complicatin...
Immunological and clinical characteristics in a cohort of Colombian pediatric patients with 22q11.2 deletion
Immunological and clinical characteristics in a cohort of Colombian pediatric patients with 22q11.2 deletion
22q11.2 deletion syndrome (22qDS) is a heterogeneous genetic disorder associated with a variety of clinical manifestations...
The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach
The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach
The mucosal origin hypothesis of rheumatoid arthritis has renewed the interest in IgA autoantibodies, but their added valu...
A novel MALT1 variant in an Egyptian patient presenting with exfoliative dermatitis: a case-based review
A novel MALT1 variant in an Egyptian patient presenting with exfoliative dermatitis: a case-based review
Inborn errors of the CARD11-BCL10-MALT1 (CBM) signalosome have recently been shown to underlie severe combined immunodefic...
miR-141-3p attenuates inflammation and oxidative stress–induced pulmonary fibrosis in ARDS via the Keap1/Nrf2/ARE signaling pathway
miR-141-3p attenuates inflammation and oxidative stress–induced pulmonary fibrosis in ARDS via the Keap1/Nrf2/ARE signaling pathway
The present research aimed to investigate the effects and mechanisms of microRNA (miR)-141-3p on pulmonary fibrosis of acu...
Analysis of binding and authentic virus-neutralizing activities of immune sera induced by various monkeypox virus antigens
Analysis of binding and authentic virus-neutralizing activities of immune sera induced by various monkeypox virus antigens
Monkeypox cases continue to increase globally, and there is an urgent need to develop a highly effective vaccine against m...
Thymic microenvironment’s impact on immunosenescence
Thymic microenvironment’s impact on immunosenescence
Age-related thymic involution is characterized by the loss of T cell development and the supporting epithelial network, wh...
SPDYC serves as a prognostic biomarker related to lipid metabolism and the immune microenvironment in breast cancer
SPDYC serves as a prognostic biomarker related to lipid metabolism and the immune microenvironment in breast cancer
Breast cancer remains the most common malignant carcinoma among women globally and is resistant to several therapeutic age...
HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still’s disease
HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still’s disease
We investigated the phenotypic characteristics of human leukocyte antigen (HLA)-E-expressing macrophages, NKG2A/CD94 expre...
Endogenous innate sensor NLRP3 is a key component in peritoneal macrophage dynamics required for cestode establishment
Endogenous innate sensor NLRP3 is a key component in peritoneal macrophage dynamics required for cestode establishment
The NLRP3 receptor can assemble inflammasome platforms to trigger inflammatory responses; however, accumulating evidence s...
Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation
Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation
T regulatory lymphocytes (Treg) expressing CCR5 exhibit strong suppression activity in various autoimmune disorders. Howev...
Investigation of the relationship of tissue-resident γδ T cells and IL-17 gene expression with the pathogenesis of autoimmune hepatitis
Investigation of the relationship of tissue-resident γδ T cells and IL-17 gene expression with the pathogenesis of autoimmune hepatitis
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease. Elevated serum immunoglobulin G (IgG) levels, autoanti...
Load More
format_indent_increase