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IgA clears gut viruses
Secretory IgA coats the intestinal microbiota and is the most abundant antibody isotype produced in the mammalian gastroin...
Short-range immunity
The double-stranded RNA (dsRNA) sensor 2′,5′-oligoadenylate synthetase (OAS) produces the linear oligonucleotide 2-5A, whi...
Skin–gut crosstalk
Skin damage can have systemic effects but whether it can result in the priming of immune responses that are spatially remo...
Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
The immune–epithelial–stromal interactions underpinning intestinal damage in celiac disease (CD) are incomplet...
Cutaneous T cell immunity
Cutaneous T cell immunity
The skin is the primary barrier against environmental insults, safeguarding the body from mechanical, chemical and pathoge...
Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
The benefit of immune checkpoint blockade for cancer therapy is limited to subsets of patients because of factors includin...
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Mucosal delivery of vaccine boosters induces robust local protective immune responses even without any adjuvants. Yet, the...
GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence
GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence
Long-lived memory CD8+ T cells are essential for the control of persistent viral infections. The mechanisms that pre...
COQ6 defies immune and metabolic expectations
COQ6 defies immune and metabolic expectations
A COQ6 variant increases susceptibility to pneumococcal infection via non-bone marrow-derived cells without affecting ubiq...
Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease
Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease
Acute lower respiratory tract infection (ALRI) remains a major worldwide cause of childhood mortality, compelling innovati...
Inborn errors of immunity caused by dominant negative interference by a BCL11B variant
Inborn errors of immunity caused by dominant negative interference by a BCL11B variant
We generated a mouse model to investigate the mechanistic basis of inborn errors of immunity caused by heterozygous BCL11B...
Nanotech unveils cytokine traces in post-COVID cardiovascular complications
Nanotech unveils cytokine traces in post-COVID cardiovascular complications
Trace levels of circulating cytokines correlate with the prevalence of cardiovascular symptoms following COVID-19.
Lactate fermentation intoxicates TILs
Lactate fermentation intoxicates TILs
Tumor-infiltrating T cells are known to encounter chronic antigens and hypoxia, which results in exhaustion and dysfunctio...
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
CD8+ T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell ex...
Immune drivers of pain resolution and protection
Immune drivers of pain resolution and protection
Immune cells are involved in the pathogenesis of pain by directly activating or sensitizing nociceptor sensory neurons. Ho...
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised in...
Age-related epithelial defects limit thymic function and regeneration
Age-related epithelial defects limit thymic function and regeneration
The thymus is essential for establishing adaptive immunity yet undergoes age-related involution that leads to compromised ...
Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity
Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity
Systemically administered cytokines are potent immunotherapeutics but can cause severe dose-limiting toxicities. To overco...
Changes in the glycosylation of circulating IgG predict future Crohn’s disease onset
Changes in the glycosylation of circulating IgG predict future Crohn’s disease onset
Patients with Crohn’s disease display an altered serum IgG glycosylation signature that is detectable many years bef...
Tracing the origins of lung fibrosis
Tracing the origins of lung fibrosis
A lung-specific fibroblast that normally provides a niche for alveolar cells has been identified as the predominant source...
ZBTB46 coordinates angiogenesis and immunity to control tumor outcome
ZBTB46 coordinates angiogenesis and immunity to control tumor outcome
Tumor angiogenesis and immunity show an inverse correlation in cancer progression and outcome1. Here, we report that ZBTB4...
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The evolution of T cell molecular signatures in the distal lung of patients with severe pneumonia is understudied. Here, w...
Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient germinal center B cell responses
Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient germinal center B cell responses
The mammalian Brg1/Brm-associated factor (BAF) complexes are major regulators of nucleosomal remodeling that are commonly ...
Immune dysregulation in long COVID
Immune dysregulation in long COVID
Profiling of plasma proteins in individuals with COVID-19 shows that complement activation and myeloid inflammation are ma...
MEF2C regulates NK cell effector functions through control of lipid metabolism
MEF2C regulates NK cell effector functions through control of lipid metabolism
Natural killer (NK) cells are a critical first line of defense against viral infection. Rare mutations in a small subset o...
TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases
TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases
Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion, limiting adaptive immunity. In co...
Author Correction: Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
Figure 1a is intended to show by northern blotting that only IL-4 among a set of six cytokines tested induces expression o...
The enduring neutrophil–stroma dance of multiple myeloma
The enduring neutrophil–stroma dance of multiple myeloma
Inflammatory memory cues initiated by neutrophils and bone marrow stroma suggest potential therapeutic targets for the tre...
An IL-1β-driven neutrophil–stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma
An IL-1β-driven neutrophil–stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma
Human bone marrow permanently harbors high numbers of neutrophils, and a tumor-supportive bias of these cells could signif...
Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis
Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis
Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use singl...
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