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Guselkumab binding to CD64+ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling
1 IntroductionIL-23 is a pro-inflammatory member of the IL-12 cytokine family and plays a pivotal role in the pathogenesis...
Understanding the relationship between cuproptosis and the development of hepatocellular carcinoma: implications for targeted therapies
1 IntroductionThe incidence of hepatocellular carcinoma (HCC) continues to rise globally, particularly in developing count...
The XBB.1.5 mRNA booster vaccine does not significantly increase the percentage of XBB.1.5 mono-reactive T cells
The XBB.1.5 mRNA booster vaccine does not significantly increase the percentage of XBB.1.5 mono-reactive T cells
IntroductionUnderstanding the dynamics of T cell responses to vaccines targeting specific SARS-CoV-2 variants is essential...
Targeted immunotherapies for Graves’ thyroidal & orbital diseases
IntroductionGraves’ disease (GD) is a common autoimmune thyroid disease affecting approximately 3% of women and 0.5% of me...
Case Report: Efficacy of ofatumumab in refractory anti-NMDAR encephalitis: case series and literature review
IntroductionN-Methyl-D-aspartate receptors (NMDARs) are glutamate-activated ion channels that play a critical role in the ...
Therapeutic strategies for adrenocortical carcinoma: integrating genomic insights, molecular targeting, and immunotherapy
1 IntroductionAdrenocortical carcinoma (ACC) is a rare and highly invasive cancer emerging from the adrenal cortex, with a...
Immune reconstitution of human cytomegalovirus-specific T lymphocytes after allogeneic hematopoietic stem cell transplantation and their predictive role in reactivation
1 IntroductionHuman cytomegalovirus (HCMV), also known as human Herpesvirus type 5, belongs to the herpesvirus beta subfam...
Pulmonary lymphoid tissue induced after SARS-CoV-2 infection in rhesus macaques
1 IntroductionLung diseases are widespread worldwide, and the recent COVID pandemic has highlighted the importance of unde...
Programmed cell death-related prognostic genes mediate dysregulation of the immune microenvironment in triple-negative breast cancer
1 IntroductionBreast cancer (BC) is one of the most common malignant tumors among women. It accounts for approximately 31%...
Prediction model of axillary lymph node status using an automated breast volume ultrasound radiomics nomogram in early breast cancer with negative axillary ultrasound
IntroductionAxillary lymph node (ALN) status is the most strongly associated factor affecting the survival and prognosis o...
Editorial: Adenine nucleotides in immunity and inflammation
Intracellular signaling encompasses two larger areas, Ca 2+ signaling evoked or modulated by AN, or signaling by the intra...
Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer
1 IntroductionColorectal cancer (CRC) is one of the three most common cancers worldwide and the second leading cause of ca...
Anti-CD137 agonist antibody–independent and clinically feasible preparation of tumor-infiltrating lymphocytes from soft tissue sarcoma and osteosarcoma
IntroductionIn adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs), a patient’s own tumor-responsive im...
Inflammatory profiling and immune cell infiltration in dysthyroid optic neuropathy: insights from bulk RNA sequencing
1 IntroductionThyroid eye disease (TED) is a significant autoimmune condition observed in 25-30% of individuals with Grave...
BCG-derived acellular membrane vesicles elicit antimycobacterial immunity and innate immune memory
1 IntroductionTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the oldest infectious diseases in h...
Zanubrutinib plus R-CHOP improves the treatment effect of newly diagnosed diffuse large B cell lymphoma with double expression of MYC and BCL-2
IntroductionDiffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma and is characterized b...
Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway
1 IntroductionWith the continuous refinement of cancer therapies, survival rates have notably improved, particularly among...
Role of endoplasmic reticulum stress in cell apoptosis induced by duck hepatitis A virus type 1 infection
IntroductionDuck viral hepatitis (DVH) is a highly contagious and acute disease that poses a significant threat to ducklin...
Insights to the HIV-associated visceral leishmaniasis clinical outcome: lessons learned about immune mediated disorders
IntroductionThe human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) pandemic over the last 40 yea...
The application of emerging immunotherapy in the treatment of prostate cancer: progress, dilemma and promise
1 IntroductionAmong elderly males, prostate cancer (PCa) is a prevalent form of cancer, coming in second in terms of occur...
Naturally selected CD7-directed CAR-T bridging allo-HSCT in refractory acute myeloid leukemia: a case report and review
Naturally selected CD7-directed CAR-T bridging allo-HSCT in refractory acute myeloid leukemia: a case report and review
Relapsed/refractory acute myeloid leukemia (R/R-AML) has a poor prognosis. CD7 is expressed in leukemic cells in 30% of pa...
Real-world study and prognostic analysis of angioimmunoblastic T-cell lymphoma
Real-world study and prognostic analysis of angioimmunoblastic T-cell lymphoma
ObjectiveTo analyze the clinical prognostic factors and treatments for angioimmunoblastic T-cell lymphoma (AITL) and devel...
Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury
Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury
Cerebral ischemic stroke accounts for more than 80% of all stroke cases. During cerebral ischemia, reactive oxygen species...
HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevance
HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevance
IntroductionUrothelial bladder cancer is frequent and exhibits diverse prognoses influenced by molecular subtypes, urothel...
Case report: The impact of dissociated response of immunotherapy on the treatment strategy of advanced head and neck cancer
Case report: The impact of dissociated response of immunotherapy on the treatment strategy of advanced head and neck cancer
Some special therapeutic responses may appear during immunotherapy, such as hyperprogression, pseudoprogression and so on....
Functional genomic analysis of the 68-1 RhCMV-Mycobacteria tuberculosis vaccine reveals an IL-15 response signature that is conserved with vector attenuation
Functional genomic analysis of the 68-1 RhCMV-Mycobacteria tuberculosis vaccine reveals an IL-15 response signature that is conserved with vector attenuation
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is a deadly infectious disease having a major impact on glob...
Immunoregulation role of the erythroid cells
Immunoregulation role of the erythroid cells
Erythroid cells are the most abundant cells in the human body. In addition to their established function in gas-transporta...
Regulation of BCR-dependent germinal center B-cell formation by HGAL and insight into its emerging myeloid ortholog, C1ORF150
Regulation of BCR-dependent germinal center B-cell formation by HGAL and insight into its emerging myeloid ortholog, C1ORF150
The specificity of cytokine and immunoreceptor signaling frequently depends upon receptor recruitment of select adaptor pr...
Reinvesting the cellular properties of human amniotic epithelial cells and their therapeutic innovations
Reinvesting the cellular properties of human amniotic epithelial cells and their therapeutic innovations
Human amniotic epithelial cells (hAECs) have shown promising therapeutic effects in numerous studies on various diseases d...
Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells
Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells
Computational strategies to extract meaningful biological information from multiomics data are in great demand for effecti...
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