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The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration
The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration
A growing body of evidence implicates inflammation as a key hallmark in the pathophysiology of Parkinson’s disease (...
The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury
The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury
Phagocyte NADPH oxidase 2 (NOX2) is an enzyme complex responsible for reactive oxygen species (ROS) production. Chronic NO...
STING activates ZBP1-mediated PANoptosis to defend against HSV-1 retinal infection
STING activates ZBP1-mediated PANoptosis to defend against HSV-1 retinal infection
Herpes simplex virus type 1 (HSV-1) is the most common cause of infectious blindness and is a major cause of acute retinal...
Fumarate-based drugs protect against neuroinflammation via upregulation of anti-ferroptotic pathways
Fumarate-based drugs protect against neuroinflammation via upregulation of anti-ferroptotic pathways
Ferroptosis is defined as iron dependent non-apoptotic cell death. It is based on peroxidation of polyunsaturated phosphol...
AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model
AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model
A Proliferation-Inducing Ligand (APRIL) is a tumour necrosis factor superfamily member with multiple effector roles in the...
Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model
Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model
Olfactory dysfunction is an underestimated symptom in multiple sclerosis (MS). Here, we examined the pathogenic mechanisms...
Fidgetin-like 2 knockdown increases acute neuroinflammation and improves recovery in a rat model of spinal cord injury
Fidgetin-like 2 knockdown increases acute neuroinflammation and improves recovery in a rat model of spinal cord injury
Spinal cord injury (SCI) can cause permanent dysfunction proceeding from multifaceted neuroinflammatory processes that con...
Lysosomal acidification impairment in astrocyte-mediated neuroinflammation
Lysosomal acidification impairment in astrocyte-mediated neuroinflammation
Astrocytes are a major cell type in the central nervous system (CNS) that play a key role in regulating homeostatic functi...
Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria
Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria
Chronic urticaria (CU) arises from a multifaceted interplay of immunological, neurological, and psychological components. ...
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis
Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study eval...
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model
Alzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive dysfunction in older adults. One of th...
IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke
IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke
Brain microglia and infiltrating monocyte-derived macrophages are vital in preserving blood vessel integrity after stroke....
Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology
Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology
Deposition of amyloid β, which is produced by amyloidogenic cleavage of APP by β- and γ-secretase, is one o...
Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling
Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling
Type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are mutual risk factors, with both conditions inducing c...
Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
Understanding the mechanism behind sepsis-associated encephalopathy (SAE) remains a formidable task. This study endeavors ...
Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body
Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body
The eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but al...
Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and cent...
Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
Presence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely re...
IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve
IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve
The spinal inflammatory signal often spreads to distant segments, accompanied by widespread pain symptom under neuropathol...
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into h...
The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome
The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction an...
Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular ...
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studi...
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicat...
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via t...
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B ...
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer&...
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concent...
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including fron...
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