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SCI Abstract
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Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model
Olfactory dysfunction is an underestimated symptom in multiple sclerosis (MS). Here, we examined the pathogenic mechanisms...
Journal Of Neuroinflammation
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Fidgetin-like 2 knockdown increases acute neuroinflammation and improves recovery in a rat model of spinal cord injury
Spinal cord injury (SCI) can cause permanent dysfunction proceeding from multifaceted neuroinflammatory processes that con...
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Lysosomal acidification impairment in astrocyte-mediated neuroinflammation
Astrocytes are a major cell type in the central nervous system (CNS) that play a key role in regulating homeostatic functi...
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Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria
Chronic urticaria (CU) arises from a multifaceted interplay of immunological, neurological, and psychological components. ...
Journal Of Neuroinflammation
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Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis
Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study eval...
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The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model
Alzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive dysfunction in older adults. One of th...
Journal Of Neuroinflammation
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IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke
Brain microglia and infiltrating monocyte-derived macrophages are vital in preserving blood vessel integrity after stroke....
Journal Of Neuroinflammation
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Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology
Deposition of amyloid β, which is produced by amyloidogenic cleavage of APP by β- and γ-secretase, is one o...
Journal Of Neuroinflammation
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Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling
Type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are mutual risk factors, with both conditions inducing c...
Journal Of Neuroinflammation
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Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
Understanding the mechanism behind sepsis-associated encephalopathy (SAE) remains a formidable task. This study endeavors ...
Journal Of Neuroinflammation
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Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body
The eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but al...
Journal Of Neuroinflammation
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Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and cent...
Journal Of Neuroinflammation
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Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
Presence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely re...
Journal Of Neuroinflammation
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IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve
The spinal inflammatory signal often spreads to distant segments, accompanied by widespread pain symptom under neuropathol...
Journal Of Neuroinflammation
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Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into h...
Journal Of Neuroinflammation
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The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction an...
Journal Of Neuroinflammation
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Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular ...
Journal Of Neuroinflammation
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Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studi...
Journal Of Neuroinflammation
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The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicat...
Journal Of Neuroinflammation
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Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via t...
Journal Of Neuroinflammation
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An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B ...
Journal Of Neuroinflammation
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Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer&...
Journal Of Neuroinflammation
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Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concent...
Journal Of Neuroinflammation
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Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Journal Of Neuroinflammation
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Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including fron...
Journal Of Neuroinflammation
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Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Journal Of Neuroinflammation
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Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells
Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-re...
Journal Of Neuroinflammation
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TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). I...
Journal Of Neuroinflammation
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Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of pr...
Journal Of Neuroinflammation
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OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
Inflammatory response triggered by innate immunity plays a pivotal element in the progress of ischemic stroke. Receptor-in...
Journal Of Neuroinflammation
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