Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, et al. Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. Lancet Global Health. 2017;5(12):e1221–e34.

Article  PubMed  Google Scholar 

Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Global Health. 2014;2(2):e106–16.

Article  PubMed  Google Scholar 

Guymer RH, Campbell TG. Age-related macular degeneration. Lancet. 2023;401(10386):1459–72.

Article  CAS  PubMed  Google Scholar 

Solomon SD, Lindsley K, Vedula SS, Krzystolik MG, Hawkins BS. Anti-vascular endothelial growth factor for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2014;8(8):Cd005139.

PubMed  Google Scholar 

Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355(14):1419–31.

Article  CAS  PubMed  Google Scholar 

Heier JS, Khanani AM, Quezada Ruiz C, Basu K, Ferrone PJ, Brittain C, et al. Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials. Lancet (London England). 2022;399(10326):729–40.

Article  CAS  PubMed  Google Scholar 

Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K. Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. 2013;120(11):2292–9.

Article  PubMed  Google Scholar 

Daniel E, Pan W, Ying G-s, Kim BJ, Grunwald JE, Ferris FL, et al. Development and Course of scars in the comparison of age-related Macular Degeneration treatments trials. Ophthalmology. 2018;125(7):1037–46.

Article  PubMed  Google Scholar 

Park YG, Park YS, Kim IB. Complement system and potential therapeutics in age-related Macular Degeneration. Int J Mol Sci. 2021;22(13).

DeMaio A, Mehrotra S, Sambamurti K, Husain S. The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases. J Neuroinflamm. 2022;19(1):251.

Article  Google Scholar 

Killick J, Morisse G, Sieger D, Astier AL. Complement as a regulator of adaptive immunity. Semin Immunopathol. 2018;40(1):37–48.

Article  CAS  PubMed  Google Scholar 

Xu H, Chen M, Forrester JV. Para-inflammation in the aging retina. Prog Retin Eye Res. 2009;28(5):348–68.

Article  PubMed  Google Scholar 

Nita M, Grzybowski A, Ascaso FJ, Huerva V. Age-related macular degeneration in the aspect of chronic low-grade inflammation (pathophysiological parainflammation). Mediat Inflamm. 2014;2014:930671.

Article  Google Scholar 

Yates JR, Sepp T, Matharu BK, Khan JC, Thurlby DA, Shahid H, et al. Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med. 2007;357(6):553–61.

Article  CAS  PubMed  Google Scholar 

Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2016;48(2):134–43.

Article  CAS  PubMed  Google Scholar 

Magnusson KP, Duan S, Sigurdsson H, Petursson H, Yang Z, Zhao Y, et al. CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med. 2006;3(1):e5.

Article  PubMed  Google Scholar 

Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci USA. 2006;103(7):2328–33.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Anderson DH, Mullins RF, Hageman GS, Johnson LV. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol. 2002;134(3):411–31.

Article  CAS  PubMed  Google Scholar 

Johnson LV, Ozaki S, Staples MK, Erickson PA, Anderson DH. A potential role for Immune Complex Pathogenesis in Drusen formation. Exp Eye Res. 2000;70(4):441–9.

Article  CAS  PubMed  Google Scholar 

Crabb JW. The proteomics of drusen. Cold Spring Harbor Perspect Med. 2014;4(7):a017194.

Article  Google Scholar 

Nittala MG, Metlapally R, Ip M, Chakravarthy U, Holz FG, Staurenghi G, et al. Association of Pegcetacoplan with Progression of Incomplete retinal pigment epithelium and outer retinal atrophy in Age-Related Macular Degeneration: a Post Hoc Analysis of the FILLY Randomized Clinical Trial. JAMA Ophthalmol. 2022;140(3):243–9.

Article  PubMed  PubMed Central  Google Scholar 

Goldberg R, Heier JS, Wykoff CC, Staurenghi G, Singh RP, Steinle N, et al. Efficacy of intravitreal pegcetacoplan in patients with geographic atrophy (GA): 12-month results from the phase 3 OAKS and DERBY studies. Investig Ophthalmol Vis Sci. 2022;63(7):1500.

Google Scholar 

Guillonneau X, Eandi CM, Paques M, Sahel JA, Sapieha P, Sennlaub F. On phagocytes and macular degeneration. Prog Retin Eye Res. 2017;61:98–128.

Article  CAS  PubMed  Google Scholar 

Grossniklaus HE, Ling JX, Wallace TM, Dithmar S, Lawson DH, Cohen C, et al. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis. 2002;8:119–26.

CAS  PubMed  Google Scholar 

Grossniklaus HE, Martinez JA, Brown VB, Lambert HM, Sternberg P Jr., Capone A Jr., et al. Immunohistochemical and histochemical properties of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol. 1992;114(4):464–72.

Article  CAS  PubMed  Google Scholar 

Combadière C, Feumi C, Raoul W, Keller N, Rodéro M, Pézard A, et al. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Investig. 2007;117(10):2920–8.

Article  PubMed  PubMed Central  Google Scholar 

Gupta N, Brown KE, Milam AH. Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Exp Eye Res. 2003;76(4):463–71.

Article  CAS  PubMed  Google Scholar 

Lad EM, Cousins SW, Van Arnam JS, Proia AD. Abundance of infiltrating CD163 + cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration. Graefe’s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2015;253(11):1941–5.

Cherepanoff S, McMenamin P, Gillies MC, Kettle E, Sarks SH. Bruch’s membrane and choroidal macrophages in early and advanced age-related macular degeneration. Br J Ophthalmol. 2010;94(7):918–25.

Article  CAS  PubMed  Google Scholar 

McLeod DS, Bhutto I, Edwards MM, Silver RE, Seddon JM, Lutty GA. Distribution and quantification of Choroidal macrophages in human eyes with age-related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016;57(14):5843–55.

Article  PubMed  PubMed Central  Google Scholar 

Greferath U, Guymer RH, Vessey KA, Brassington K, Fletcher EL. Correlation of Histologic Features with in vivo imaging of reticular pseudodrusen. Ophthalmology. 2016;123(6):1320–31.

Article  PubMed  Google Scholar 

Hagbi-Levi S, Grunin M, Jaouni T, Tiosano L, Rinsky B, Elbaz-Hayoun S, et al. Proangiogenic characteristics of activated macrophages from patients with age-related macular degeneration. Neurobiol Aging. 2017;51:71–82.

Article  CAS  PubMed  Google Scholar 

Sennlaub F, Auvynet C, Calippe B, Lavalette S, Poupel L, Hu SJ, et al. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol Med. 2013;5(11):1775–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaarniranta K, Salminen A. Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors. J Mol Med. 2009;87(2):117–23.

Article  CAS  PubMed  Google Scholar 

Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxidative damage and age-related macular degeneration. Mol Vis. 1999;5:32.

CAS  PubMed  Google Scholar 

Ishibashi T, Murata T, Hangai M, Nagai R, Horiuchi S, Lopez P, et al. Advanced glycation end products in age-related macular degeneration. Archives Ophthalmol (Chicago Ill: 1960). 1998;116(12):1629–32.

Article  CAS  Google Scholar 

Golestaneh N, Chu Y, Xiao Y-Y, Stoleru GL, Theos AC. Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration. Cell Death Dis. 2018;8(1):e2537–e.

Article  Google Scholar 

Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011;471(7338):325–30.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Karunadharma PP, Nordgaard CL, Olsen TW, Ferrington DA. Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010;51(11):5470–9.

Article  PubMed  PubMed Central