Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

PubMed  Google Scholar 

Hannafon BN. Involvement of the tumor microenvironment in the pathogenesis of breast cancer. Am J Pathol. 2021;191:1328–9.

PubMed  Google Scholar 

Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79:4557–66.

CAS  PubMed  PubMed Central  Google Scholar 

DeSantis CE, et al. Breast cancer statistics, 2019. CA Cancer J Clin. 2019;69:438–51.

PubMed  Google Scholar 

Mittra I, et al. Effect of screening by clinical breast examination on breast cancer incidence and mortality after 20 years: prospective, cluster randomised controlled trial in Mumbai. BMJ. 2021;372:n256.

PubMed  PubMed Central  Google Scholar 

Chhabra Y, Weeraratna AT. Fibroblasts in cancer: unity in heterogeneity. Cell. 2023;186:1580–609.

CAS  PubMed  PubMed Central  Google Scholar 

Hu D, et al. Cancer-associated fibroblasts in breast cancer: challenges and opportunities. Cancer Commun (Lond). 2022;42:401–34.

PubMed  Google Scholar 

Mittal S, Brown NJ, Holen I. The breast tumor microenvironment: role in cancer development, progression and response to therapy. Expert Rev Mol Diagn. 2018;18:227–43.

CAS  PubMed  Google Scholar 

Klemm F, et al. Interrogation of the microenvironmental landscape in brain tumors reveals disease-specific alterations of immune cells. Cell. 2020;181:1643-1660.e1617.

CAS  PubMed  PubMed Central  Google Scholar 

Gao D, et al. Microenvironmental regulation in tumor progression: interactions between cancer-associated fibroblasts and immune cells. Biomed Pharmacother. 2023;167:115622.

CAS  PubMed  Google Scholar 

Wculek SK, et al. Dendritic cells in cancer immunology and immunotherapy. Nat Rev Immunol. 2020;20:7–24.

CAS  PubMed  Google Scholar 

Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 2022;21:799–820.

CAS  PubMed  PubMed Central  Google Scholar 

Zipinotti Dos Santos D, et al. The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape. Cell Commun Signal. 2023;21:161.

CAS  PubMed  PubMed Central  Google Scholar 

Song L, et al. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy. Nat Commun. 2020;11:5842.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Xu X, Ye Q. Metabolism and immunity in breast cancer. Front Med. 2021;15:178–207.

PubMed  Google Scholar 

Tuluhong D, et al. Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability. Exp Cell Res. 2023;433:113805.

CAS  PubMed  Google Scholar 

Jiang P, Du W, Mancuso A, Wellen KE, Yang X. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. 2013;493:689–93.

CAS  PubMed  PubMed Central  Google Scholar 

Ferraro GB, et al. Fatty acid synthesis is required for breast cancer brain metastasis. Nat Cancer. 2021;2:414–28.

CAS  PubMed  PubMed Central  Google Scholar 

Yao X, et al. Simvastatin induced ferroptosis for triple-negative breast cancer therapy. J Nanobiotechnology. 2021;19:311.

CAS  PubMed  PubMed Central  Google Scholar 

Martinez-Outschoorn UE, Peiris-Pagés M, Pestell RG, Sotgia F, Lisanti MP. Cancer metabolism: a therapeutic perspective. Nat Rev Clin Oncol. 2017;14:11–31.

CAS  PubMed  Google Scholar 

Chu DT, et al. The effects of adipocytes on the regulation of breast cancer in the tumor microenvironment: an update. Cells 2019;8:857.

Corn KC, Windham MA, Rafat M. Lipids in the tumor microenvironment: From cancer progression to treatment. Prog Lipid Res. 2020;80:101055.

CAS  PubMed  PubMed Central  Google Scholar 

Lyu X, et al. Contribution of adipocytes in the tumor microenvironment to breast cancer metabolism. Cancer Lett. 2022;534:215616.

CAS  PubMed  Google Scholar 

Bernard JJ, Wellberg EA. The tumor promotional role of adipocytes in the breast cancer microenvironment and macroenvironment. Am J Pathol. 2021;191:1342–52.

PubMed  PubMed Central  Google Scholar 

Habanjar O, et al. Crosstalk of inflammatory cytokines within the breast tumor microenvironment. Int J Mol Sci. 2023;24:4002.

Tian W, et al. Leukotrienes in tumor-associated inflammation. Front Pharmacol. 2020;11:1289.

CAS  PubMed  PubMed Central  Google Scholar 

Ji H, et al. Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions. Signal Transduct Target Ther. 2023;8:367.

PubMed  PubMed Central  Google Scholar 

Cheng A, Solomon MJ. Speedy/Ringo C regulates S and G2 phase progression in human cells. Cell Cycle. 2008;7:3037–47.

CAS  PubMed  Google Scholar 

Mourón S, et al. RINGO C is required to sustain the spindle-assembly checkpoint. J Cell Sci. 2010;123:2586–95.

PubMed  Google Scholar 

Guan T, et al. Phosphorylation of USP29 by CDK1 governs TWIST1 stability and oncogenic functions. Adv Sci (Weinh). 2023;10:e2205873.

PubMed  Google Scholar 

Nie L, et al. CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nat Commun. 2019;10:5114.

CAS  PubMed  PubMed Central  Google Scholar 

Alsaleem MA, et al. A novel prognostic two-gene signature for triple negative breast cancer. Mod Pathol. 2020;33:2208–20.

CAS  PubMed  Google Scholar 

Kursa MB, Rudnicki WR. Feature selection with the Boruta package. J Stat Softw. 2010;36:1–13.

Google Scholar 

Sotiriou C, et al. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst. 2006;98:262–72.

CAS  PubMed  Google Scholar 

Newman AM, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12:453–7.

CAS  PubMed  PubMed Central  Google Scholar 

Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18:220.

PubMed  PubMed Central  Google Scholar 

Ru B, et al. TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019;35:4200–2.

CAS  PubMed  Google Scholar 

Geeleher P, Cox NJ, Huang RS. Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. Genome Biol. 2014;15:R47.

PubMed  PubMed Central  Google Scholar 

Li X, et al. WNT/β-catenin signaling pathway regulating T cell-inflammation in the tumor microenvironment. Front Immunol. 2019;10:2293.

CAS  PubMed  PubMed Central  Google Scholar 

Peng CW, Liu XL, Liu X, Li Y. Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance. J Transl Med. 2010;8:101.

PubMed  PubMed Central  Google Scholar 

Zhang P, et al. Identification of biomarkers related to immune and inflammation in membranous nephropathy: comprehensive bioinformatic analysis and validation. Front Immunol. 2023;14:1252347.

CAS  PubMed  PubMed Central