Role of the basophil activation test in the diagnosis and management of immediate drug reaction to injectable growth hormone preparation: a case report

Wittrup M, Pildal J, Rasmussen AK, Skov BG, Petersen J. 2003 Mandrup-Poulsen TR. Systemic and local allergy to human insulin. Ugeskr Laeger. 19 165(21):2207–8

Wonders J, Eekhoff EM, Heine R, Bruynzeel DP, Rustemeyer T. Insulin allergy: background, diagnosis and treatment [in Dutch]. Ned Tijdschr Geneeskd. 2005;149:2783–8.

PubMed  CAS  Google Scholar 

Petersen KG, Khalaf A, Zeisel HJ, Stryjek-Kaminska D, Kerp L. IgE antibodies to human growth hormone prior to and during treatment. Acta Endocrinol. 1989;121:501–4.

CAS  Google Scholar 

Khalaf AN, Kerp L, Schliebs B, Jägle M. Petersen KG Natural occurrence of IgE antibodies to peptide hormones in man. Eur J Clin Invest. 1989;19(5):464–5.

Article  PubMed  CAS  Google Scholar 

Junprasert J, Javier FC 3rd, Rodriguez JA, Moore C, Sorensen RU. Successful intravenous desensitization of growth hormone hypersensitivity. J Pediatr Endocrinol Metab. 1997;10:223–6.

Article  PubMed  CAS  Google Scholar 

Walker SB, Weiss ME, Tattoni DS. Systemic reaction to human growth hormone treated with acute desensitization. Pediatrics. 1992;90(1 Pt 1):108–9.

Article  PubMed  CAS  Google Scholar 

Albertsson-Wikland K. Clinical trial with authentic recombinant somatropin in Sweden and Finland. Acta Paediatr Scand Suppl. 1987;331:28–34.

Article  PubMed  CAS  Google Scholar 

Forte WC, Kochi C, Faria CD, Calliari LE, Monte O, Longui CA. Growth hormone therapy and hypersensitivity type III reaction: a contraindication for desensitization. Arq Bras Endocrinol Metabol. 2011;55:78–80.

Article  PubMed  Google Scholar 

Soares MQ, Mendonca EF. Lichen planus-like drug reaction associated with recombinant human growth hormone therapy in a child patient with Turner syndrome. Dermatol Online J. 2016;22:14.

Article  Google Scholar 

Oono T, Arata J. Childhood lichen planus in a patient receiving growth hormone for dwarfism. Dermatology. 1996;192:87–8.

Article  PubMed  CAS  Google Scholar 

Acikgoz G, Ozmen I, Tunca M, Akar A, Arca E, Saifurrahman S. Psoriasis induced by growth hormone therapy in a patient with Turner’s syndrome. Int J Dermatol. 2015;54:e132–5.

Article  PubMed  Google Scholar 

Pirgon O, Atabek ME, Sert A. Psoriasis following growth hormone therapy in a child. Ann Pharmacother. 2007;41:157–60.

Article  PubMed  CAS  Google Scholar 

Maghnie M, Borroni G, Larizza D, Lorini R, Girani MA, Rabbiosi G, Severi F. Relapsing eruptive psoriasis and immunological changes triggered by growth hormone therapy in a growth hormone-deficient girl. Dermatologica. 1990;181:139–41.

Article  PubMed  CAS  Google Scholar 

Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, Rouzaire P, Ebo DG, Sabato V, Sanz M, Pecaric-Petkovic T, Patil SU, Hausmann OV, Shreffler WG, Korosec P, Knol EF. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. 2015;70:1393–405.

Article  PubMed  CAS  Google Scholar 

Mayorga C, Çelik GE, Pascal M, Hoffmann HJ, Eberlein B, Torres MJ, Brockow K, Garvey LH, Barbaud A, Madrigal-Burgaleta R, Caubet JC, Ebo DG. Flow-based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper. Allergy. 2024;79(3):580–600

Romano A, Atanaskovic-Markovic M, Barbaud A, Bircher AJ, Brockow K, Caubet JC, Celik G, Cernadas J, Chiriac AM, Demoly P, Garvey LH, Mayorga C, Nakonechna A, Whitaker P, Torres MJ. Towards a more precise diagnosis of hypersensitivity to beta-lactams - an EAACI position paper. Allergy. 2020;75(6):1300–2131.

Article  PubMed  Google Scholar 

Bavbek S, Pagani M, Alvarez-Cuesta E, Castells M, Dursun AB, Hamadi S, Madrigal-Burgaleta R, Sanchez-Sanchez S, Vultaggio A. Hypersensitivity reactions to biologicals: An EAACI position paper. Allergy. 2022;77(1):39–54.

Article  PubMed  Google Scholar 

Atanaskovic-Markovic M, Gomes E, Cernadas JR, du Toit G, Kidon M, Kuyucu S, Mori F, Ponvert C, Terreehorst I. Caubet JC Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper. Pediatr Allergy Immunol. 2019;30(3):269–76.

Article  PubMed  Google Scholar 

Carbonell A, Escudero AI, Miralles JC, González A, Navarro C, Cardona P, Jimeno L, Pineda F. Anaphylaxis due to poloxamer 238. J Investig Allergol Clin Immunol. 2018;28(6):419–20.

Article  PubMed  CAS  Google Scholar 

Ionova Y, Wilson L. Biologic excipients: importance of clinical awareness of inactive ingredients. PLoS One. 2020 25;15(6):e0235076

Bruusgaard-Mouritsen MA, Nasser S, Garvey LH, Krantz MS, Stone CA Jr. Anaphylaxis to excipients in current clinical practice: evaluation and management. Immunol Allergy Clin North Am. 2022;42(2):239–67.

Article  PubMed  PubMed Central  Google Scholar 

Kwek JW, Chakraborty S, Kuan KC, Yeo WC, Yin H, Liu CK, Guo L, Zidar J, Li C, Lim FCH. Interactions between poloxamer, PEOx-PPOy-PEOx, and non-ionic surfactant, sucrose monolaurate: a study on potential allergenic effect using model phospholipid membrane. Colloids Surf B Biointerfaces. 2022;209(Pt 1)

Venturini Díaz M, Vidal Oribe I, D’Elia Torrence D, Hernández Alfonso P, Alarcón GE. New challenges in drug allergy: the resurgence of excipients. Curr Treat Options Allergy. 2022;9(3):273–91.

Article  PubMed  PubMed Central  Google Scholar 

Chirumbolo S, Vella A, Ortolani R, De Gironcoli M, Solero P, Tridente G, Bellavite P. Differential response of human basophil activation markers: a multi-parameter flow cytometry approach. Clin Mol Allergy. 2008;6:12.

Article  PubMed  PubMed Central  Google Scholar 

Céspedes JA, Fernández-Santamaría R, Ariza A, Bogas G, Doña I, Rondón C, Salas M, Labella M, Frecha C, Mayorga C, Torres MJ, Fernández TD. Diagnosis of immediate reactions to amoxicillin: comparison of basophil activation markers CD63 and CD203c in a prospective study. Allergy. 2023;78(10):2745–55.

Article  PubMed  Google Scholar 

Restivo V, Candore G, Barrale M, Caravello E, Graziano G, Onida R, Raineri M, Tiralongo S, Brusca I. Allergy to polyethilenglicole of anti-SARS CoV2 vaccine recipient: a case report of young adult recipient and the management of future exposure to SARS-CoV2. Vaccines (Basel). 2021;9(5):412.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Comments (0)

No login
gif