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Environmental monitoring from the air with hyperspectral reporters
Environmental monitoring from the air with hyperspectral reporters
Hyperspectral reporters allow bacteria on the ground to be imaged by high-flying drones, expanding environmental monitorin...
Application of a sunlight-switched sugar signal increases wheat yield in the field
Application of a sunlight-switched sugar signal increases wheat yield in the field
Crop yield improvement has plateaued in the past three decades, owing largely to genetic bottlenecks in the germplasm of s...
The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease
The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease
Transplantation of human fetal ventral mesencephalic tissue in individuals with Parkinson’s disease has yielded clin...
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes
Despite progress in mapping protein–protein interactions, their tissue specificity is understudied. Here, given that...
Evolution-guided protein design of IscB for persistent epigenome editing in vivo
Evolution-guided protein design of IscB for persistent epigenome editing in vivo
Naturally existing enzymes have been adapted for a variety of molecular technologies, with enhancements or modifications t...
Author Correction: Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
These authors contributed equally: Lei Chang, Yang Xie.Department of Cellular and Molecular Medicine, University of Califo...
A protein association atlas for human tissues
A protein association atlas for human tissues
Proteomics samples of human cancer biopsies were combined to derive an atlas of protein–protein associations for hum...
Targeting a cell surface RNA-binding protein driving acute myeloid leukemia
Targeting a cell surface RNA-binding protein driving acute myeloid leukemia
How modifications to RNA molecules and the proteins they interact with on the cell surface contribute to cancer is largely...
A bacterial neoantigen cancer vaccine
Neoantigen cancer vaccines hold great promise for cancer treatment but are often limited by the immunosuppressive tumor en...
First proof-of-mechanism for RNA editing in humans
The first clinical results for an RNA-editing oligonucleotide designed to correct a disease-causing single-base mutation i...
Shot in the arm for biotech fuels
The US Department of Energy (DOE) in October conditionally committed nearly $3 billion to two companies to scale up the pr...
Cancer cases in bluebird’s gene therapy trials
Over 10% of patients with a fatal neurodegenerative disease who received bluebird bio’s FDA-approved gene therapy Skysona ...
From Bench to Podcast: Ali Shaib
From Bench to Podcast: Ali Shaib
In this episode, Associate Editor Cláudia Vilhena sits down with Ali Shaib, the lead author of an exciting new study showc...
Directed evolution of engineered virus-like particles with improved production and transduction efficiencies
Directed evolution of engineered virus-like particles with improved production and transduction efficiencies
Engineered virus-like particles (eVLPs) are promising vehicles for transient delivery of proteins and RNAs, including gene...
Author Correction: Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Genetically encoding colors and images into bioengineered microbial materials
Genetically encoding colors and images into bioengineered microbial materials
Using synthetic biology, we engineered a cellulose-producing bacterium that can produce eumelanin and respond to light, so...
Capturing and modeling cellular niches from dissociated single-cell and spatial data
Capturing and modeling cellular niches from dissociated single-cell and spatial data
Cells interact with their local environment to enact global tissue function. By harnessing gene–gene covariation in ...
Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression
Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression
Environmental concerns are driving interest in postpetroleum synthetic textiles produced from microbial and fungal sources...
The covariance environment defines cellular niches for spatial inference
The covariance environment defines cellular niches for spatial inference
A key challenge of analyzing data from high-resolution spatial profiling technologies is to suitably represent the feature...
Antivenom slithers back to life
Snakebite treatment still relies on antivenom, a 130-year old technology, but biotech is on the job.
Gene trajectory inference for single-cell data by optimal transport metrics
Gene trajectory inference for single-cell data by optimal transport metrics
Single-cell RNA sequencing has been widely used to investigate cell state transitions and gene dynamics of biological proc...
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
CRISPR–Cas9 paired with adeno-associated virus serotype 6 (AAV6) is among the most efficient tools for producing tar...
A monomeric StayGold fluorescent protein
A monomeric StayGold fluorescent protein
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite fav...
From AI to the Y chromosome (and everything in between)
Nature Biotechnology editors pick their favorite research articles from 2023.
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s annual survey highlights academic start ups that are, among other things, correcting misfolde...
The world’s first CRISPR therapy is approved: who will receive it?
The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this ...
Tracing the fate of AAV vectors in the body
Tracing the fate of AAV vectors in the body
A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.
DNA nanodevices map intracellular ions
DNA nanodevices map intracellular ions
Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium acti...
Top ten news stories in 2023
Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashin...
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from huma...
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