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A bacterial neoantigen cancer vaccine
Neoantigen cancer vaccines hold great promise for cancer treatment but are often limited by the immunosuppressive tumor en...
First proof-of-mechanism for RNA editing in humans
The first clinical results for an RNA-editing oligonucleotide designed to correct a disease-causing single-base mutation i...
Shot in the arm for biotech fuels
The US Department of Energy (DOE) in October conditionally committed nearly $3 billion to two companies to scale up the pr...
Cancer cases in bluebird’s gene therapy trials
Over 10% of patients with a fatal neurodegenerative disease who received bluebird bio’s FDA-approved gene therapy Skysona ...
From Bench to Podcast: Ali Shaib
From Bench to Podcast: Ali Shaib
In this episode, Associate Editor Cláudia Vilhena sits down with Ali Shaib, the lead author of an exciting new study showc...
Directed evolution of engineered virus-like particles with improved production and transduction efficiencies
Directed evolution of engineered virus-like particles with improved production and transduction efficiencies
Engineered virus-like particles (eVLPs) are promising vehicles for transient delivery of proteins and RNAs, including gene...
Author Correction: Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Genetically encoding colors and images into bioengineered microbial materials
Genetically encoding colors and images into bioengineered microbial materials
Using synthetic biology, we engineered a cellulose-producing bacterium that can produce eumelanin and respond to light, so...
Capturing and modeling cellular niches from dissociated single-cell and spatial data
Capturing and modeling cellular niches from dissociated single-cell and spatial data
Cells interact with their local environment to enact global tissue function. By harnessing gene–gene covariation in ...
Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression
Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression
Environmental concerns are driving interest in postpetroleum synthetic textiles produced from microbial and fungal sources...
The covariance environment defines cellular niches for spatial inference
The covariance environment defines cellular niches for spatial inference
A key challenge of analyzing data from high-resolution spatial profiling technologies is to suitably represent the feature...
Antivenom slithers back to life
Snakebite treatment still relies on antivenom, a 130-year old technology, but biotech is on the job.
Gene trajectory inference for single-cell data by optimal transport metrics
Gene trajectory inference for single-cell data by optimal transport metrics
Single-cell RNA sequencing has been widely used to investigate cell state transitions and gene dynamics of biological proc...
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
CRISPR–Cas9 paired with adeno-associated virus serotype 6 (AAV6) is among the most efficient tools for producing tar...
A monomeric StayGold fluorescent protein
A monomeric StayGold fluorescent protein
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite fav...
From AI to the Y chromosome (and everything in between)
Nature Biotechnology editors pick their favorite research articles from 2023.
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s annual survey highlights academic start ups that are, among other things, correcting misfolde...
The world’s first CRISPR therapy is approved: who will receive it?
The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this ...
Tracing the fate of AAV vectors in the body
Tracing the fate of AAV vectors in the body
A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.
DNA nanodevices map intracellular ions
DNA nanodevices map intracellular ions
Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium acti...
Top ten news stories in 2023
Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashin...
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from huma...
Spatial methods for microbiome–host interactions
Spatial methods for microbiome–host interactions
Spatial transcriptomics offers a glimpse of how microbiomes interact with their hosts.
Spatial host–microbiome sequencing reveals niches in the mouse gut
Spatial host–microbiome sequencing reveals niches in the mouse gut
Mucosal and barrier tissues, such as the gut, lung or skin, are composed of a complex network of cells and microbes formin...
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
The interactions of microorganisms among themselves and with their multicellular host take place at the microscale, formin...
Modeling human trunk development
Modeling human trunk development
A model of the embryonic human trunk attains a more mature developmental stage than previous models.
Antibiotic nanoparticles boost antitumor immunity
Antibiotic nanoparticles boost antitumor immunity
Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T ce...
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and...
A bacterial assist for CAR-T cells
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Precise intraoperative brain tumor classification
Central nervous system (CNS) tumors are a leading cause of cancer-related deaths, particularly among children, and the pri...
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