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SCI Abstract
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Cis‐regulation of antisense noncoding RNA at the JAZF1 locus in type 2 diabetes
Abstract Background Several genomic loci of type 2 diabetes (T2D) nominated in genome-wide association studies (GWASs) hav...
Journal Of Gene Medicine
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Long noncoding RNA SNHG9 facilitates growth of glioma stem‐like cells via miR‐326/SOX9 axis
Abstract Background Glioma stem-like cells (GSCs) are greatly responsible for the progression of glioma. Long noncoding RN...
Journal Of Gene Medicine
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Association study of miR‐149, miR‐196a2, and miR‐499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population
Abstract Background Accumulating evidence suggests that several microRNA (miRNA) polymorphisms are closely associated with...
Journal Of Gene Medicine
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A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion
Abstract Background Intellectual disability (ID) is a hallmark of many rare disorders that are highly heterogeneous and co...
Journal Of Gene Medicine
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LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Recent studies have demons...
Journal Of Gene Medicine
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CDK14/β‐catenin/TCF4/miR‐26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo
Abstract Introduction Chemotherapy and radiotherapy have been reported to be basically ineffective for pancreatic ductal a...
Journal Of Gene Medicine
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Circular RNA circ_0040823 inhibits the proliferation of acute myeloid leukemia cells and induces apoptosis by regulating miR‐516b/PTEN
Abstract Objective Endogenous circular RNAs (circRNAs) and microRNAs (miRNAs) have been shown to regulate the pathogenesis...
Journal Of Gene Medicine
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Noninvasive detection of fetal genetic variations through polymorphic site sequencing of maternal plasma DNA
Abstract Background Noninvasive prenatal testing (NIPT) for common fetal aneuploidies has been widely adopted in clinical ...
Journal Of Gene Medicine
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Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating miR‐564/ZIC2 axis
Abstract Background Circular RNA derived from dipeptidyl peptidase 4 (circDPP4; ID: hsa_circ_0056881) is one top increased...
Journal Of Gene Medicine
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Global Brain Delivery of Neuroligin 2 Gene Ameliorates Seizures in A Mouse Model of Epilepsy
Abstract Background Despite the increasing availability of effective drugs, around one-third of patients with epilepsy are...
Journal Of Gene Medicine
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Noninvasive Detection of Fetal Genetic Variations through Polymorphic Sites Sequencing of Maternal Plasma DNA
Abstract Background Non-invasive prenatal testing (NIPT) for common fetal aneuploidies has been widely adopted in clinical...
Journal Of Gene Medicine
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Design of a new cell penetrating peptide for DNA, siRNA and mRNA delivery
Abstract Background Delivery systems, including peptide-based ones, that destabilize endosomes in a pH-dependent manner ar...
Journal Of Gene Medicine
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Human leukocyte antigen class I association with occult hepatitis B virus infection in the Shaanxi Han group: Analysis at the haplotype level
Abstract Background Human leucocyte antigen (HLA) class I genes and haplotypes correlate with hepatitis B virus (HBV) infe...
Journal Of Gene Medicine
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AGER gene variant as a risk factor for juvenile idiopathic arthritis
Abstract Background The AGER gene encodes a cell surface multiligand receptor of advanced glycation end-products that are ...
Journal Of Gene Medicine
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A novel compound heterozygous variant linked to hematuria in a family with hereditary factor VII deficiency
Abstract Background Hereditary Factor VII Deficiency (FVIID) is a rare congenital autosomal recessive bleeding disorder. I...
Journal Of Gene Medicine
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The pathological tissue expression pattern and clinical significance of m6A‐regulatory genes in non‐small cell lung cancer
Abstract Background Aberrant expression of m6A-related proteins contributes to the occurrence and progression of non-small...
Journal Of Gene Medicine
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Marked Increase in Tumor Transfection with a Truncated Branched Polymer
Abstract Background We previously determined that polyplexes formed by linear H2K peptides were more effective in transfec...
Journal Of Gene Medicine
comment
0
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LINC01291 promotes hepatocellular carcinoma development by targeting miR‐186‐5p/OXSR1 axis
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Recent studies have demons...
Journal Of Gene Medicine
comment
0
thumb_up
0
EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR‐129‐5p
Abstract Background This study was designed to verify whether enhancer of zeste homolog 2 (EZH2) affects intervertebral di...
Journal Of Gene Medicine
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Human Leukocyte Antigen Class I Association with Occult Hepatitis B Virus Infection in Shaanxi Han Group: Analysis at the Haplotype Level
Abstract Background Previous researches have confirmed that human leucocyte antigen (HLA) class I genes and haplotypes wer...
Journal Of Gene Medicine
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Inhibition of lncRNA MALAT1 reduces myocardial ischemia‐reperfusion injury of rat cardiomyocytes through regulating the miR‐135a‐5p/HIF1AN axis
Abstract Background Many studies have elucidated the regulatory roles of long non-coding RNAs in cardiovascular diseases. ...
Journal Of Gene Medicine
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Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR‐214
Abstract Background Circular RNA itchy E3 ubiquitin protein ligase (circ-ITCH) has previously been reported to play a key ...
Journal Of Gene Medicine
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LncRNA CDKN2B‐AS1 contributes to glioma development by regulating the miR‐199a‐5p/DDR1 axis
Abstract Background Although cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) is upregulated in glioma, i...
Journal Of Gene Medicine
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CSRP3, p.Arg122*, is Responsible for Hypertrophic Cardiomyopathy in a Chinese Family
Abstract Background Hypertrophic cardiomyopathy (HCM) is a hereditary disease manifested by a thickened ventricular wall. ...
Journal Of Gene Medicine
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Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR‐515‐5p
Abstract Background Circular RNAs (circRNAs) are key regulators in the progression of various cancers. Abnormal DNA methyl...
Journal Of Gene Medicine
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Hsa_circ_0040809 regulates colorectal cancer development by up‐regulating methyltransferase DNMT1 via targeting miR‐515‐5p
Abstract Background Circular RNAs (circRNAs) are key regulators in the progression of various cancers. Abnormal DNA methyl...
Journal Of Gene Medicine
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The diagnostic significance of circulating lncRNA ADAMTS9‐AS2 tumor biomarker in non‐small cell lung cancer among the Egyptian population
Abstract Background Long non-coding RNA ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2 (ADAMTS9...
Journal Of Gene Medicine
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Inhibition of the long non‐coding RNA UNC5B‐AS1/miR‐4455/RSPO4 axis reduces cervical cancer growth in vitro and in vivo
Abstract Background Long non-coding RNAs (lncRNAs) are significant regulatory factors for the initiation and development o...
Journal Of Gene Medicine
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Copy number variation characterization and possible candidate genes in miscarriage and stillbirth by next‐generation sequencing analysis
Abstract Background The present study aimed to explore the etiological relationship between miscarriage and stillbirth and...
Journal Of Gene Medicine
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Synovial mesenchymal stem cell‐derived extracellular vesicles containing microRN555A‐26a‐5p ameliorate cartilage damage of osteoarthritis
Abstract Background Osteoarthritis (OA) is a degenerative disease characterized by cartilage damage. We aimed to improve t...
Journal Of Gene Medicine
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