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Effects of preoperative neoadjuvant chemotherapy on postoperative delirium in patients with gynecological tumor surgery: an observational study
Effects of preoperative neoadjuvant chemotherapy on postoperative delirium in patients with gynecological tumor surgery: an observational study
To investigate whether neoadjuvant chemotherapy (NACT) increases the incidence of postoperative delirium (POD) in patients...
A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade
A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade
Small cell lung cancer (SCLC) has an extremely poor prognosis. Despite high initial response rates to chemotherapy and mod...
Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review
Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review
Colorectal cancer (CRC) exhibits a substantial morbidity and mortality rate, with its aetiology and pathogenesis remain el...
Age differences in the treatment of lung cancer–a cohort study among 42,000 patients from Germany
Age differences in the treatment of lung cancer–a cohort study among 42,000 patients from Germany
We aimed to describe treatment of lung cancer patients in Germany based on health claims data, focusing particularly on di...
Insights into cancer characteristics among SARS-CoV-2 infected hospitalized patients: a comprehensive analysis from the National Clinical Registry for COVID-19
Insights into cancer characteristics among SARS-CoV-2 infected hospitalized patients: a comprehensive analysis from the National Clinical Registry for COVID-19
Cancer outcome is dependent on multiple predetermining factors including cancer, type of cancer and its related factors. T...
CT-defined muscle density as a prognostic factor in multiple myeloma undergoing autologous stem cell therapy: a retrospective single center study
CT-defined muscle density as a prognostic factor in multiple myeloma undergoing autologous stem cell therapy: a retrospective single center study
Skeletal muscle quality assessment can be performed by cross-sectional imaging. Skeletal muscle density (SMD) identified t...
Inhibition of NPC1 suppresses cell proliferation and β-catenin signaling activation of liver cancer
Inhibition of NPC1 suppresses cell proliferation and β-catenin signaling activation of liver cancer
Niemann-Pick Type C1 (NPC1) plays a significant role in the development of liver diseases and liver cancer. Our objective ...
Opportunities and challenges of using circulating tumor DNA to predict lung cancer immunotherapy efficacy
Opportunities and challenges of using circulating tumor DNA to predict lung cancer immunotherapy efficacy
Immune checkpoint inhibitors (ICIs), particularly anti-programmed death 1 (PD-1)/ programmed death ligand 1 (PD-L1) antibo...
Identification of a novel molecular classification for hepatocellular carcinoma based on disulfideptosis-related genes and its potential prognostic significance
Identification of a novel molecular classification for hepatocellular carcinoma based on disulfideptosis-related genes and its potential prognostic significance
Globally, hepatocellular carcinoma (HCC) is one of the most prevalent and deadly malignant tumors. A recent study proposed...
Multi-classification of breast cancer pathology images based on a two-stage hybrid network
Multi-classification of breast cancer pathology images based on a two-stage hybrid network
In current clinical medicine, pathological image diagnosis is the gold standard for cancer diagnosis. After pathologists d...
Efficacy of sintilimab combined with neoadjuvant chemotherapy and trastuzumab in conversional treatment of locally advanced HER2-positive gastric cancer: case analysis and literature review
Efficacy of sintilimab combined with neoadjuvant chemotherapy and trastuzumab in conversional treatment of locally advanced HER2-positive gastric cancer: case analysis and literature review
Regional lymph nodes that are fixed and fused into clusters or those exhibiting metastases outside the regional lymph node...
Osteopontin: an indispensable component in common liver, pancreatic, and biliary related disease
Osteopontin: an indispensable component in common liver, pancreatic, and biliary related disease
The liver, gallbladder, and pancreas constitute a critically important system of digestive and endocrine organs in the hum...
The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model
The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model
The intricate interplay between stemness markers and cell death pathways significantly influences the pathophysiology of c...
Dosimetric evaluation of different cylinder diameters in three-dimensional vaginal brachytherapy for early-stage endometrial cancer
Dosimetric evaluation of different cylinder diameters in three-dimensional vaginal brachytherapy for early-stage endometrial cancer
To evaluate the dosimetric, radiobiological, and toxicity differences between different cylinder diameters (d) in high-dos...
USP33 is an integrin α6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis
USP33 is an integrin α6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis
The deubiquitinating enzymes (DUBs) have been linked to cancer initiation and progression. Although ubiquitin-specific pro...
TTK promotes HER2 + breast cancer cell migration, apoptosis, and resistance to targeted therapy by modulating the Akt/mTOR axis
TTK promotes HER2 + breast cancer cell migration, apoptosis, and resistance to targeted therapy by modulating the Akt/mTOR axis
HER2 + breast cancer is a malignant neoplasm with a high degree of aggressiveness and therapeutic challenge. I...
Zinc oxide nanoparticles mitigate the malignant progression of ovarian cancer by mediating autophagy-dependent ferroptosis
Zinc oxide nanoparticles mitigate the malignant progression of ovarian cancer by mediating autophagy-dependent ferroptosis
Previous studies have shown that ZnO-NPs induce autophagy and inhibit the malignant progression of ovarian cancer (OC) cel...
Comparing epidemiological and clinical data from RPS patients documented in a German cancer registry to a cohort from TARPSWG reference centres
Comparing epidemiological and clinical data from RPS patients documented in a German cancer registry to a cohort from TARPSWG reference centres
Retroperitoneal sarcomas (RPS) are rare, heterogeneous tumours. Treatment recommendations are mainly derived from cohorts ...
Primary cardiac synovial sarcoma originating from the atrial septum and associated pulmonary infarction: a case report
Primary cardiac synovial sarcoma originating from the atrial septum and associated pulmonary infarction: a case report
Primary cardiac synovial sarcoma is a rare condition with limited treatment options for advanced stages. Surgery and chemo...
Effect of TTF-1 expression on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer
Effect of TTF-1 expression on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer
The choice between immunotherapy with a checkpoint inhibitor (CPI) and chemo-/immunotherapy (CIT) in patients with NSCLC s...
Bibliometric analysis and visualisation of research hotspots and frontiers on omics in osteosarcoma
Bibliometric analysis and visualisation of research hotspots and frontiers on omics in osteosarcoma
Omics technology has become a widely applied biological science that can be used to study the etiology, pathogenesis, and ...
Epigenetic profiling of prostate cancer reveals potential prognostic signatures
Epigenetic profiling of prostate cancer reveals potential prognostic signatures
While epigenetic profiling discovered biomarkers in several tumor entities, its application in prostate cancer is still li...
Association between four insulin resistance surrogates and the risk of esophageal cancer: a prospective cohort study using the UK Biobank
Association between four insulin resistance surrogates and the risk of esophageal cancer: a prospective cohort study using the UK Biobank
This study explored the association between triglyceride-glucose (TyG), TyG index with body mass index (TyG-BMI), triglyce...
ROS-mediated ITGB5 promotes tongue squamous cell carcinoma metastasis through epithelial mesenchymal transition and cell adhesion signal pathway
ROS-mediated ITGB5 promotes tongue squamous cell carcinoma metastasis through epithelial mesenchymal transition and cell adhesion signal pathway
Integrin β5 (ITGB5) is an integrin β subunit member widely expressed in the human bodies, especially in cancer c...
Savolitinib conferred sensitivity in a patient with D1228H mutation-induced capmatinib-resistant MET exon 14 skipping mutated lung adenocarcinoma
Savolitinib conferred sensitivity in a patient with D1228H mutation-induced capmatinib-resistant MET exon 14 skipping mutated lung adenocarcinoma
Traditionally, the D1228 E/G/H/N mutation has been thought to cause Type I MET-TKI resistance. We reported a 75-year-old f...
Clinicopathological association of CD93 expression in gastric adenocarcinoma
Clinicopathological association of CD93 expression in gastric adenocarcinoma
CD93 was recently identified as a promising therapeutic target for angiogenesis blockade in various tumors. Herein, we aim...
Application of electronic nose technology in the diagnosis of gastrointestinal diseases: a review
Application of electronic nose technology in the diagnosis of gastrointestinal diseases: a review
Electronic noses (eNoses) are electronic bionic olfactory systems that use sensor arrays to produce response patterns to d...
Sulindac exhibits anti-proliferative and anti-invasive effects in uterine serous carcinoma cells
Sulindac exhibits anti-proliferative and anti-invasive effects in uterine serous carcinoma cells
Uterine serous carcinoma (USC) is a highly aggressive and frequently recurring subtype of endometrial cancer with limited ...
HER2 amplification subtype intrahepatic cholangiocarcinoma exhibits high mutation burden and T cell exhaustion microenvironment
HER2 amplification subtype intrahepatic cholangiocarcinoma exhibits high mutation burden and T cell exhaustion microenvironment
This study aimed to establish a uniform standard for the interpretation of HER2 gene and protein statuses in intrahepatic ...
Testosterone therapy as a novel approach to the management of cytopenias in myelodysplastic neoplasms: a review of literature and case report
Testosterone therapy as a novel approach to the management of cytopenias in myelodysplastic neoplasms: a review of literature and case report
To explore the potential of testosterone therapy in managing cytopenias in myelodysplastic neoplasm and investigate the li...
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